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Director of Graduate Studies
Address and Contact Information
MRC Postdoctoral Fellow, Vaccine and Infectious Disease Organization (VIDO), Canada
PhD, University of Ottawa, Ottawa, Canada
DVM, Seoul National University, Seoul, Korea
PREVIOUS ACADEMIC POSITIONS
Visiting Professor, Leiden University Medical Center, Leiden, Netherlands
Associate Professor, Department of Pathobiology, Ontario Veterinary College, University of Guelph, ON, Canada (~2006)
Assistant Professor, Department of Pathobiology, Ontario Veterinary College, University of Guelph, ON, Canada (Tenured in 1998)
Post-doctoral Fellow, Medical Research Council (MRC) of Canada, Western College of Veterinary Medicine/Veterinary Infectious Disease Organization (VIDO), Canada
Viruses infect humans, animals, plants, insects, and microbes, and more than 90% of human illnesses are caused by viruses. Animal viruses can cross species boundaries to infect human populations and viral infections of domestic animals can cause an enormous economic and societal impact. Virus replication relies on host cell machineries and thus during infection continuous interaction occurs between virus and host. Virology is the study of the molecular and cellular aspects of such infections and aims to develop control measures for infection of medical and veterinary importance. We use Porcine Reproductive and Respiratory Syndrome (PRRS) virus as a model to study cell-virus interactions and to understand viral evasion strategies against host immune surveillance. We have developed a system called "reverse genetics," and using this system we are able to generate genetically engineered mutant viruses. This tool enables us to study various pathogenic mechanisms and to investigate the role that individual viral proteins play during infection.
- Dr. Yoo studied Veterinary Medicine at Seoul National University, Korea. He completed his Master of Science degree in microbiology at the same institution and moved to Canada for further studies in virology at the medical school in the University of Ottawa. His doctoral advisor, Dr. C. Y. Kang, was a virologist trained in the laboratory of Dr. H. Temin, who received the Nobel Prize for the 'provirus' hypothesis, which led to the discovery of reverse transcriptase. Dr. Yoo's doctoral research involved molecular investigation of the hantavirus genome. He completed his PhD in 1988. Dr. Yoo pursued his post-doctoral training at Vaccines and Infectious Disease Organization under the supervision of Dr. L.A. Babiuk, who now serves as Vice-President for Research at the University of Alberta. Dr. Yoo was appointed professor at Ontario Veterinary College, University of Guelph, and initiated his current research on Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), which has begun to emerge as a new and significant pathogen.
- Dr. Yoo's career in research is unique as his training and education has taken place in a medical and veterinary setting. His research strengths lie in molecular virology and modern vaccinology, which serve to form the basis of his current research themes and direction.
- Virology and Viral Pathogenesis (PATH433/ MCB433)
- Mechanisms Viral Pathogenesis (PATH519/ MCB561)
- Pathobiologic Basis of Disease II (VM607)
- Thesis Research (PATH599)
- Seminar/Journal Club (PATH590)
- Special Problems (PATH592)
- Undergraduate Research (PATH 290)
- Biochemistry Senior Thesis Research (BIOC492)
- Research Project (MCB290)
- Zhang, Q., Ke, H., Blikslager, A., Fujita, T., Yoo, D. 2018. Type III interferon restriction by porcine epidemic diarrhea virus and the role of viral protein nsp1 in IRF1 signaling. J. Virol. 92(4): e01677-17.
- Zhang, Q., Ma, J., Yoo, D. 2017. Inhibition of NF-κB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evaion. Virology 510: 111-126.
- Han, M., Ke, H., Zhang, Q., Yoo, D. 2017.Nuclear imprisonment of host cellular mRNA by nsp1ß protein of porcine reproductive and respiratory syndrome virus. Virology 505: 42-55. (Cover page article of Volume 505, May 2017).
- Sun, Y., Ke, H., Han M., Chen, N., Fang, W., Yoo, D. 2016. Nonstructural protein 11 of porcine reproductive and respiratory syndrome virus suppresses both MAVS and RIG-1 expression as one of the mechanisms to antagonize type I interferon production. PLoS ONE 11(12): e0168314. http://dx.doi.org/10.1371/journal.pone.0168314.
- Hu Y, Cong X, Chen L, Qi Jm Wu X, Zhou M, Yoo D, Li F, Sun W, Wu J, Zhao X, Chen Z, Yu J, Du Y, Wang J. 2016. Synergy of TLR3 and TLR7 ligands significantly enhances function of DCs to present inactivated PRRS virus antigen through TRIF/MyD88/NF-κB signaling pathway. Sci. Reports. 6:23877. www.nature.com/articles/srep2397.
- Zhang Q, Shi K, Yoo D. 2016. Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1. Virology 489: 252-268.
- Han M, Kim CY, Rowland RRR, Fang Y, Kim D, Yoo D. 2014. Biogenesis of non-structural protein 1 (nsp1) and nsp1-mediated type I interferon modulation in Arteriviruses. Virology 458-469:136-150.
- Du Y, Bi J, Liu J, Liu X, Wu X, Jiang P, Yoo D, Zhang Y, Wu J, Wan R, Zhao X, Guo L, Sun W, Cong X, Chen L, Wang J. 2014. 3Cpro of FMDV antagonizes IFN signaling pathway by blocking STAT1/STAT2 nuclear translocation. J. Virol. 88:4908-4920.
- Hicks JA, Yoo D, Liu HC. 2013. Characterization of changes in microRNA expression and function in PRRSV-infected macrophages. PLoS One 8(12): e82054. http://dx.doi.org/10.1371/journal.pone. 0082054.
- Du Y, Pattnaik AK, Song C, Yoo D, Li G. 2012. Glycosyl-phosphatidylinositol (GPI)-anchored membrane association of the porcine reproductive and respiratory syndrome virus GP4 glycoprotein and its co-localization with CD163 in lipis rafts. Virology 424:18-31.
- Song C, Krell P, Yoo D. 2010. Nonstructural protein 1a subunit-based inhibition of NF-kB activation and suppression of interferon-ß production by porcine reproductive and respiratory syndrome virus. Virology 407:268-280.
- Kim O, Sun Y, Lai FW, Song C, Yoo D.2010. Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells. Virology 402:315-326.
- Pei Y, Hodgins DC, Wu J, Welch SKW, Calvert JG, Li G, Du Y, Song C, Yoo D. 2009. Porcine reproductive and respiratory syndrome virus as a vector: Immunogenicity of green fluorescent protein and porcine circovirus type-2 capsid expressed from dedicated subgenomic RNAs. Virology 389:91-99.
- Song C, Lu R, Bienzle D, Liu HC, Yoo D. 2009. Interaction of porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain containing protein. Biol. Chem. 390:215-223.
- Lee C, Hodgins DC, Calvert JG, Welch SK, Jolie R, Yoo D. 2006. Mutations in the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication. Virology 346:238-250 (Cover page article, Issue 1).
- Lee C, Calvert JG, Welch SK, Yoo D. 2006. A DNA-launched reverse genetic system for porcine reproductive and respiratory syndrome virus reveals that homodimerization of the nucleocapsid protein is essential for virus infectivity. Virology 331:47-62.
- Yoo D, Wootton S, Li G, Song C, Rowland RR. 2003. Co-localization and interaction of the porcine arterivirus nucleocapsid protein with the small nucleolar RNA-associated protein fibrillarin. J. Virol. 77:12173-12183.
- Wootton S, Yoo D. 2003. Homo-oligomerization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein and the role of disulfide linkages. J. Virol. 77: 4546-4557.
- Wootton S, Rowland RR, Yoo D.2002. Phosphorylation of the porcine reproductive and respiratory syndrome virus nucleocapsid protein. J. Virol. 76:10569-10576.
- Immune Modulation and Evasion Strategy of PRRS Virus
- PRRS Virus as a Multivalent Vaccine Vector
- Molecular Bases for Interferon Modulation by PRRS Virus and PEDV
- USDA AFRI-NIFA 2013-2018 Immune Evasion of PRRSV and Vaccine Design (Role: PI)
- USDA CSREES-NRI 2008-2012, Immune Modulation of PRRSV (Role: PI)
- USDA HATCH, PRRS Virus as a Multivalent Vaccine Vector (Role: PI)
- NIH T32, Infection Biology Training Program (Role: co-PI)
- NIH T35, Summer Training in Translational Biomedical Research (Role: Co-PI)
Honors and Awards
- Pfizer Award for Research Excellence, University of Illinois at Urbana-Champaign, USA (2012)
- Presidential Distinguished Professor Award (Research), University of Guelph, Ontario, Canada (2003)
- Pfizer Faculty Award for Research Excellence, University of Guelph, Ontario, Canada (2003)
- Honorary Senior Scientist, Korean Ministry of Agriculture and Fisheries, Rural Development Administration, Veterinary Research Institute, Republic of Korea (1992-2003)
Other Campus Affiliations
- Campus Research Board
- Institutional Biosafety Committee
- CVM Research Committee
- American Society for Virology
- American Society for Microbiology
- Conference of Research Workers in Animal Diseases
- 18th International Nidovirus Symposium 2014, Scientific Program Committee, Spain
- International Committee on Taxonomy of Viruses, Arterivirus Study Group 2005-2011
- International Pig Veterinary Society Conference 2012 Scientific Committee, Korea
- International Pig Veterinary Society Conference 2010 Scientific Committee, Canada
- 17th International Nidovirus Symposium 2011, Scientific Program Committee, Michigan