Research

Discovery at the College of Veterinary Medicine encompasses the spectrum of biomedical sciences.

The Office of Research and Advanced Studies serves a variety of functions:

• Serves as a resource to faculty and student researchers in the college;
• Administers the joint DVM/PhD Veterinary Medical Scholars Program;
• Administers the Summer Research Training Program for veterinary students;
• Oversees the college’s shared research equipment program;
• Administers the college’s internal research grants program;
• Organizes the annual Research Day program.

Research and graduate education occur within the three academic departments, listed below, with guidance and support from the Office of Research and Advanced Studies.

• Department of Comparative Biosciences
• Department of Pathobiology
• Department of Veterinary Clinical Medicine

To see the breadth of scholarly activity of college faculty, visit individual faculty biosketch pages or view the sampling of recent grants and publications below.

Selected Recent Grant Awards

DNA Methylation Inhibitor Therapy for Testicular Cancer
M Spinella, S Spinella; $503,327; National Institutes of Health

Study the Role of hnRNP I in Downregulating TLR Signaling and Inducing Intestinal Epithelial Immune Tolerance
W Mei; $75,210; National Institutes of Health

T1 Mapping and Calculation of Extracellular Volume Fraction in Cats with Hypertrophic Cardiomyopathy using Cardiac Magnetic Resonance Imaging
R Fries, S Keating, J Vitt; $33,850; Winn Feline Foundation

COTC026: Evaluation of a Recombinant, Attenuated Listeria monocytogenes Expressing a Chimeric Human HER2/neu Protein in Dogs with Osteosarcoma in the Adjuvant Setting
T Fan; $585,144; Morris Animal Foundation

Metagenomic Investigation into the Cause of Shell Disease in Western Pond Turtles (Actinemys marmorata)
K Terio, D Woodburn; $20,567; Association of Zoos and Aquariums

Conditional Protein Degradation Tool for Cryptosporidium
S Vinayak; $100,000; Bill and Melinda Gates Foundation

Snake Fungal Disease Survey: Natural Resource Manager Training and Data Collection
M Allender; $106,631; Department of Defense

Physical Chemistry of Herpesvirus Infectivity
A Evilevitch; $389,676; National Science Foundation

Phthalate Exposure and Hot Flashes in Midlife Women
J Flaws, R Smith; $851,639; National Institutes of Health

The Upper Midwestern Center of Excellence for Vector-borne Diseases
M O’Hara; $692,255; Centers for Disease Control

Publications Recently Indexed in PubMed

The spread of bovine tuberculosis in Canadian shared pastures: data, model, and simulations.
Rossi G, Aubry P, Dubé C, Smith RL. Transbound Emerg Dis. 2018 Nov 8. doi: 10.1111/tbed.13066. [Epub ahead of print] PMID: 30407739

Cholinergic and dopaminergic interactions alter attention and response inhibition in Long-Evans rats performing the 5-choice serial reaction time task.
Balachandran RC, Sieg ML, Tran CTQ, Clancy BM, Beaudin SA, Eubig PA. Pharmacol Biochem Behav. 2018 Oct 26;175:160-173. doi: 10.1016/j.pbb.2018.10.006. [Epub ahead of print] PMID: 30393121

The spread of mosquito-borne viruses in modern times: A spatio-temporal analysis of dengue and chikungunya.
Rossi G, Karki S, Smith RL, Brown WM, Ruiz MO. Spat Spatiotemporal Epidemiol. 2018 Aug;26:113-125. doi: 10.1016/j.sste.2018.06.002. Epub 2018 Jun 18. PMID: 30390927

Pharmacokinetics of human recombinant C1-esterase inhibitor and development of anti-drug antibodies in healthy dogs.
Wong C, Muguiro DH, Lavergne S, Behling-Kelly E, Goggs R. Vet Immunol Immunopathol. 2018 Sep;203:66-72. doi: 10.1016/j.vetimm.2018.08.006. Epub 2018 Aug 23. PMID: 30243377

Recent advances in conservative and surgical treatment options of common equine foot problems.
Gutierrez-Nibeyro SD, McCoy AM, Selberg KT. Vet J. 2018 Jul;237:9-15. doi: 10.1016/j.tvjl.2018.05.003. Epub 2018 May 17. Review. PMID: 30089549

Prevalence of Urogenital Carcinoma in Stranded California Sea Lions ( Zalophus californianus) from 2005-15.
Deming AC, Colegrove KM, Duignan PJ, Hall AJ, Wellehan JFX, Gulland FMD. J Wildl Dis. 2018 Jul;54(3):581-586. doi: 10.7589/2017-08-208. Epub 2018 Mar 2. PMID: 29498901

Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice.
Richardson KA, Hannon PR, Johnson-Walker YJ, Myint MS, Flaws JA, Nowak RA. Reprod Toxicol. 2018 Apr;77:70-79. doi: 10.1016/j.reprotox.2018.01.006. Epub 2018 Feb 16. PMID: 29458081

Canine spinal meningiomas and nerve sheath tumours in 34 dogs (2008-2016): Distribution and long-term outcome based upon histopathology and treatment modality.
Lacassagne K, Hearon K, Berg J, Séguin B, Hoyt L, Byer B, Selmic LE. Vet Comp Oncol. 2018 Sep;16(3):344-351. doi: 10.1111/vco.12385. Epub 2018 Jan 23. PMID: 29363264