Research

Discovery at the College of Veterinary Medicine encompasses the spectrum of biomedical sciences.

The Office of Research and Advanced Studies serves a variety of functions:

• Serves as a resource to faculty and student researchers in the college;
• Administers the joint DVM/PhD Veterinary Medical Scholars Program;
• Administers the Summer Research Training Program for veterinary students;
• Oversees the college’s shared research equipment program;
• Administers the college’s internal research grants program;
• Organizes the annual Research Day program.

Research and graduate education occur within the three academic departments, listed below, with guidance and support from the Office of Research and Advanced Studies.

• Department of Comparative Biosciences
• Department of Pathobiology
• Department of Veterinary Clinical Medicine

To see the breadth of scholarly activity of college faculty, visit individual faculty biosketch pages or view the sampling of recent grants and publications below.

Selected Recent Grant Awards

DNA Methylation Inhibitor Therapy for Testicular Cancer
M Spinella, S Spinella; $503,327; National Institutes of Health

Study the Role of hnRNP I in Downregulating TLR Signaling and Inducing Intestinal Epithelial Immune Tolerance
W Mei; $75,210; National Institutes of Health

T1 Mapping and Calculation of Extracellular Volume Fraction in Cats with Hypertrophic Cardiomyopathy using Cardiac Magnetic Resonance Imaging
R Fries, S Keating, J Vitt; $33,850; Winn Feline Foundation

COTC026: Evaluation of a Recombinant, Attenuated Listeria monocytogenes Expressing a Chimeric Human HER2/neu Protein in Dogs with Osteosarcoma in the Adjuvant Setting
T Fan; $585,144; Morris Animal Foundation

Metagenomic Investigation into the Cause of Shell Disease in Western Pond Turtles (Actinemys marmorata)
K Terio, D Woodburn; $20,567; Association of Zoos and Aquariums

Conditional Protein Degradation Tool for Cryptosporidium
S Vinayak; $100,000; Bill and Melinda Gates Foundation

Snake Fungal Disease Survey: Natural Resource Manager Training and Data Collection
M Allender; $106,631; Department of Defense

Physical Chemistry of Herpesvirus Infectivity
A Evilevitch; $389,676; National Science Foundation

Phthalate Exposure and Hot Flashes in Midlife Women
J Flaws, R Smith; $851,639; National Institutes of Health

The Upper Midwestern Center of Excellence for Vector-borne Diseases
M O’Hara; $692,255; Centers for Disease Control

Publications Recently Indexed in PubMed

Genetic characterization of extraintestinal Escherichia coli isolates from chicken, cow and swine.
Chen L, Wang L, Yassin AK, Zhang J, Gong J, Qi K, Ganta RR, Zhang Y, Yang Y, Han X, Wang C. AMB Express. 2018 Jul 17;8(1):117. doi: 10.1186/s13568-018-0646-8. PMID: 30019301

A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy.
Yazdy MM, Coull BA, Gardiner JC, Aguiar A, Calafat AM, Xiaoyun Ye, Schantz SL, Korrick SA. J Expo Sci Environ Epidemiol. 2018 Jul 17. doi: 10.1038/s41370-018-0050-0. [Epub ahead of print] PMID: 30018406

Intracellular calcium chelating agent (BAPTA-AM) aids stallion semen cooling and freezing-thawing.
Wu S, Canisso IF, Yang W, Ul Haq I, Liu Q, Han Y, Zeng S. Reprod Domest Anim. 2018 Jul 9. doi: 10.1111/rda.13245. [Epub ahead of print] PMID: 29984866

Stochastic lattice-based modelling of malaria dynamics.
Le PVV, Kumar P, Ruiz MO. Malar J. 2018 Jul 5;17(1):250. doi: 10.1186/s12936-018-2397-z. PMID: 29976221 Free PMC Article

Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.
Choi HW, Shin PG, Lee JH, Choi WS, Kang MJ, Kong WS, Oh MJ, Seo YB, Kim GD. Int J Mol Med. 2018 Feb;41(2):1103-1109. doi: 10.3892/ijmm.2017.3309. Epub 2017 Dec 5. PMID: 29207042

In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin.
Maxwell EA, Phillips H, Schaeffer DJ, Fan TM. Vet Surg. 2018 Feb;47(2):219-226. doi: 10.1111/vsu.12709. Epub 2017 Nov 9. PMID: 29120489

Nerve Growth Factor-Beta, purified from bull seminal plasma, enhances corpus luteum formation and conceptus development in Bos taurus cows.
Stewart JL, Mercadante VRG, Dias NW, Canisso IF, Yau P, Imai B, Lima FS. Theriogenology. 2018 Jan 15;106:30-38. doi: 10.1016/j.theriogenology.2017.10.007. Epub 2017 Oct 7. PMID: 29035835

Effects of profound acidemia on the dynamic glucose and insulin response and plasma potassium and phosphorus concentrations during an intravenous glucose tolerance test in neonatal calves.
Trefz FM, Lorenz I, Constable PD. J Dairy Sci. 2017 Nov;100(11):9163-9176. doi: 10.3168/jds.2017-12690. Epub 2017 Sep 6. PMID: 28888605

Postmortem DTI reveals altered hippocampal connectivity in wild sea lions diagnosed with chronic toxicosis from algal exposure.
Cook PF, Berns GS, Colegrove K, Johnson S, Gulland F. J Comp Neurol. 2018 Feb 1;526(2):216-228. doi: 10.1002/cne.24317. Epub 2017 Oct 11. PMID: 28875534

Estradiol cypionate aided treatment for experimentally induced ascending placentitis in mares.
Curcio BR, Canisso IF, Pazinato FM, Borba LA, Feijó LS, Muller V, Finger IS, Toribio RE, Nogueira CEW. Theriogenology. 2017 Oct 15;102:98-107. doi: 10.1016/j.theriogenology.2017.03.010. Epub 2017 Mar 29. PMID: 28755579

Bisphenol A impairs decidualization of human uterine stromal fibroblasts.
Olson MR, Su R, Flaws JA, Fazleabas AT. Reprod Toxicol. 2017 Oct;73:339-344. doi: 10.1016/j.reprotox.2017.07.008. Epub 2017 Jul 17. PMID: 28729173 Free PMC Article

Three-dimensional printing of orbital and peri-orbital masses in three dogs and its potential applications in veterinary ophthalmology.
Dorbandt DM, Joslyn SK, Hamor RE. Vet Ophthalmol. 2017 Jan;20(1):58-64. doi: 10.1111/vop.12352. Epub 2016 Jan 22. PMID: 26801834