Research

Discovery at the College of Veterinary Medicine encompasses the spectrum of biomedical sciences.

The Office of Research and Advanced Studies serves a variety of functions:

• Serves as a resource to faculty and student researchers in the college;
• Administers the joint DVM/PhD Veterinary Medical Scholars Program;
• Administers the Summer Research Training Program for veterinary students;
• Oversees the college’s shared research equipment program;
• Administers the college’s internal research grants program;
• Organizes the annual Research Day program.

Research and graduate education occur within the three academic departments, listed below, with guidance and support from the Office of Research and Advanced Studies.

• Department of Comparative Biosciences
• Department of Pathobiology
• Department of Veterinary Clinical Medicine

To see the breadth of scholarly activity of college faculty, visit individual faculty biosketch pages or view the sampling of recent grants and publications below.

Selected Recent Grant Awards

SELECTED RECENT GRANT AWARDS

Genomic Imprinting in Circuits for Social Behavior
P Bonthuis; $249,000; National Institutes of Health

Great Ape Heart Disease: Harnessing the Power of Pathology to Improve the Clinical Care and Welfare of Ape Collections
K Terio; $253,583; Zoo Atlanta

Marek’s Disease Virus UL13 Virion Protein US10 and Cellular LY6E in Horizontal Transmission
K Jarosinski; $500,000; USDA NIFA

Functional Characterization of Novel Poxviral Immunomodulatory Proteins
D Rock; $500,000; USDA NIFA

Animal Disease Training and Exercises Across the Veterinary Educational Spectrum (AD-TEAVES)
Y Johnson-Walker; $429,835; USDA APHIS

A Multi-Audience Online Educational Program for Rural Practitioners and Veterinary Students Entering Rural Veterinary Practice
J Lowe; $236,750; USDA NIFA

Establish a Pregnant Sow Model for Assessment of Influenza Vaccine Safety and Efficacy During Pregnancy
Y Fang; $331,173; National Institutes of Health

Enhancing Undergraduate Research: Genome Data Mining and Laboratory Investigation to Reveal the Fungal Agglutinin-Like Sequence Family
L Hoyer; $475,800; National Institutes of Health

Maternal Control of Germ Line Development
J Yang; $823,151; National Institutes of Health

Risk Genes for Osteochrondrosis: An Integrated Approach
A McCoy; $149,906; Morris Animal Foundation

Characterization of the Fecal Microbiome in Dogs with Spinal Cord Injury Secondary to Intervertebral Disc Disease (IVDD)
K Foss; $14,958; American Kennel Club Canine Health Foundation

Detection of Elephant Endotheliotropic Herpesvirus (EEHV) 1A DNA using in situ Hybridization
J Landolfi; $12,150; International Elephant Foundation

Publications Recently Indexed in PubMed

A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.
Schantz SL, Eskenazi B, Buckley JP, Braun JM, Sprowles JN, Bennett DH, Cordero J, Frazier JA, Lewis J, Hertz-Picciotto I, Lyall K, Nozadi SS, Sagiv S, Stroustrup A, Volk HE, Watkins DJ; program collaborators for Environmental influences on Child Health Outcomes. Environ Res. 2020 May 23;188:109709. doi: 10.1016/j.envres.2020.109709. [Epub ahead of print] Review. PMID: 32526495

Chronic in vivo exposure to Helicobacter pylori VacA: Assessing the efficacy of automated and long-term intragastric toxin infusion.
Holland RL, Bosi KD, Harpring GH, Luo J, Wallig M, Phillips H, Blanke SR. Sci Rep. 2020 Jun 9;10(1):9307. doi: 10.1038/s41598-020-65787-3. PMID: 32518315

A porcine macrophage cell line that supports high levels of replication of OURT88/3, an attenuated strain of African swine fever virus.
Portugal R, Goatley LC, Husmann R, Zuckermann FA, Dixon LK. Emerg Microbes Infect. 2020 Dec;9(1):1245-1253. doi: 10.1080/22221751.2020.1772675. PMID: 32515659

A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
Bhurke A, Kannan A, Neff A, Ma Q, Laws MJ, Taylor RN, Bagchi MK, Bagchi IC. Proc Natl Acad Sci U S A. 2020 Jun 8. pii: 202000810. doi: 10.1073/pnas.2000810117. [Epub ahead of print] PMID: 32513733

Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity.
Kim DH, Park HJ, Park HS, Lee JU, Ko C, Gye MC, Choi JM. Exp Mol Med. 2019 Apr 15;51(4):1-9. doi: 10.1038/s12276-019-0237-z. PMID: 30988419

RNF216 is essential for spermatogenesis and male fertility†.
Melnick AF, Gao Y, Liu J, Ding D, Predom A, Kelly C, Hess RA, Chen C. Biol Reprod. 2019 May 1;100(5):1132-1134. doi: 10.1093/biolre/ioz006. PMID: 30649198

Exocytosis of progeny infectious varicella-zoster viral particles via a mannose-6-phosphate receptor pathway without xenophagy following secondary envelopment.
Girsch JH, Jackson W, Carpenter JE, Moninger TO, Jarosinski KW, Grose C. J Virol. 2020 Jun 3. pii: JVI.00800-20. doi: 10.1128/JVI.00800-20. [Epub ahead of print] PMID: 32493818

Characterization of performance on an automated visual recognition memory task in 7.5-month-old infants.
Dzwilewski KLC, Merced-Nieves FM, Aguiar A, Korrick SA, Schantz SL. Neurotoxicol Teratol. 2020 May 30:106904. doi: 10.1016/j.ntt.2020.106904. [Epub ahead of print] PMID: 32485220

Fluoroquinolone exposure in utero did not affect articular cartilage of resulting foals.
Ellerbrock RE, Canisso IF, Larsen RJ, Garrett KS, Stewart MC, Herzog KK, Kersh ME, Moshage SG, Podico G, Lima FS, Childs BA. Equine Vet J. 2020 Jun 1. doi: 10.1111/evj.13295. [Epub ahead of print] PMID: 32479667

COVID-19 and veterinarians for one health, zoonotic- and reverse-zoonotic transmissions.
Yoo HS, Yoo D. J Vet Sci. 2020 May;21(3):e51. doi: 10.4142/jvs.2020.21.e51. PMID: 32476324

Complete Genome Sequence of SARS-CoV-2 in a Tiger from a U.S. Zoological Collection.
Wang L, Mitchell PK, Calle PP, Bartlett SL, McAloose D, Killian ML, Yuan F, Fang Y, Goodman LB, Fredrickson R, Elvinger F, Terio K, Franzen K, Stuber T, Diel DG, Torchetti MK. Microbiol Resour Announc. 2020 May 28;9(22). pii: e00468-20. doi: 10.1128/MRA.00468-20. PMID: 32467283

Effects of Isoflurane Anesthesia on the Hematologic Values of Rehabilitated Wild Owls.
Berg KJ, Whittington JK, Watson MK, Wiggen K, Blalock A, Mitchell MA. J Avian Med Surg. 2019 Dec 9;33(4):369-380. doi: 10.1647/2017-333. PMID: 31833305

Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries.
Rattan S, Beers HK, Kannan A, Ramakrishnan A, Brehm E, Bagchi I, Irudayaraj JMK, Flaws JA. Toxicol Appl Pharmacol. 2019 Sep 15;379:114629. doi: 10.1016/j.taap.2019.114629. Epub 2019 Jun 15. PMID: 31211961

Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2′-O-Methyltransferase and the Endocytosis Signal of the Spike Protein.
Hou Y, Ke H, Kim J, Yoo D, Su Y, Boley P, Chepngeno J, Vlasova AN, Saif LJ, Wang Q. J Virol. 2019 Jul 17;93(15). pii: e00406-19. doi: 10.1128/JVI.00406-19. Print 2019 Aug 1. PMID: 31118255

Development of a triplex real-time RT-PCR assay for detection and differentiation of three US genotypes of porcine hemagglutinating encephalomyelitis virus.
Wang L, Eggett TE, Lanka S, Fredrickson RL, Li G, Zhang Y, Yoo D, Bowman AS. J Virol Methods. 2019 Jul;269:13-17. doi: 10.1016/j.jviromet.2019.04.008. Epub 2019 Apr 5. PMID: 30959064