Pathobiology

Pathobiology encompasses a diverse complement of disciplines to elucidate mechanisms of host-pathogen interactions. Research leads to tools for detection, control, and prevention of infectious diseases in humans and animals.

Department of Pathobiology

2522 Vet Med Basic Sciences Bldg.
2001 South Lincoln Avenue
Urbana, IL 61802

Raymond “Bob” Rowland, PhD
Professor and Head

Dongwan Yoo, PhD, DVM
Professor and Director of Graduate Programs

Karen Nichols
Administrative Assistant

P: (217) 333-2449 | F: (217) 244-7421

Overview

The Department of Pathobiology addresses complex problems in biomedical and veterinary infectious diseases.

Emphasis is placed on studies of microbiology, immunology, and epidemiology, with the goals of making healthy humans and animals, along with a healthy environment.

In the veterinary professional degree program, the department teaches courses in both the basic science and clinical portions of the second-year curriculum.

The department is the home to the Pathobiology Graduate Program.

Areas of Research

Bacterial/fungal infections, vaccines, and therapeutics

Evolution of antimicrobial resistance and virulence in Staphylococcus species

The role of the microbiome in health and disease

Fungal genomics

Molecular mechanism of virulence in Streptococcus pneumoniae and Pseudomonas aeruginosa

Diagnosis of bacterial infections

Immunological bases for fungal pathogenesis and resistance

Intestinal infections of human and swine; novel vaccines for prevention of intestinal infections

Epidemiology and population medicine

Preventative measures for foreign animal diseases

Tickborne disease prevention; analysis of large datasets

Spatial epidemiology and surveillance of foodborne pathogens

Parasitic infections and antihelmintics

Cryptosporidium genetics and novel drug targets

Cryptosporidium gene function and identification of novel drug targets; phospholipid biosynthetic pathways in parasitic nematodes

Viral infections and vaccines

Role of receptor glycosylation in SARS-CoV2 infection

Molecular mechanisms of nidovirus pathogenesis of humans and swine; vaccines platforms for swine

Marek’s Disease Virus (MDV) and other herpesvirus of poultry and humans; poultry vaccines

African swine fever virus (ASFV) and poxviruses; vaccines for ASFV in swine

Host factors involved in porcine reproductive and respiratory syndrome virus (PRRSV) pathogenesis

Molecular mechanisms of arterivirus infections and novel vaccines based on PRRSV infectious clones and reverse genetics

Swine vaccines, including PRRSV