Professional Profile

PhD, University of Ottawa, Ottawa, Canada
MSc, Seoul National University, Seoul, Korea
DVM, Seoul National University, Seoul, Korea

Previous Professional Positions

Professor Special Appointment (특임교수), Seoul National University, Seoul, Korea
Visiting Professor, Leiden University Medical Center, Leiden, The Netherlands
Associate Professor, Department of Pathobiology, University of Guelph, Canada
Assistant Professor, Department of Pathobiology, University of Guelph, Canada
Medical Research Council of Canada Post-doctoral Fellow, Veterinary Infectious Disease Organization, Canada

We study the molecular and cellular aspects of viral infections to develop control measures against infections of medical and veterinary importance. We use arteriviruses and coronaviruses as model viruses. We investigate how the innate immunity reacts to invading viruses and, in turn, how invading viruses evade the host immune surveillance for their survival and replication. We use a reverse genetics system to engineer viral RNA genomes and generate mutant viruses to study pathogenic mechanisms for viral infection in cells and animals.

(Full List of Publications) 

(Selected Publications)

Jiang S, Sui C, Wu X, Jiang P, Hu Y, Cong X, Li J, Yoo D, Miller LC, Lee C, Du Y, Qi J. (2024). Swine NONO promotes IRF3-mediated antiviral immune response by detecting PRRSV N protein. PLOS Pathogens 20(10): e1012622. 

Su C-M, Kim J, Tang J, Hung YF, Zuckermann F, Husmann R, Roady P, Kim J, Lee Y-M, Yoo D. (2024). A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen. PLOS Pathogens 20(3):e1012128. 

Hu H, Wu X, Tian Y, Jiang D, Ren J, Li Z, Ding X, Zhang Q, Yoo D, Miller LC, Lee C, Cong X, Li J, Du Y, Qi J. (2024) GTPase activity of porcine Mx1 plays a dominant role in inhibiting the N-nsp9 interaction and thus inhibiting PRRSV replication. Journal of Virology 98:e0184423. 

Su CM, Du Y, Rowland RRR, Wang Q, Yoo D. (2023) Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses. Frontiers in Immunology 14:1172000.

Wu X, Hu Y, Sui C, Pan L, Yoo D, Miller L, Lee C, Cong X, Li J, Du Y, Qi J. (2022). Multiple Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication. Journal of Virology 96:e0061222.

Sui C, Jiang D, Wu X, Liu S, Li F, Pan L, Cong X, Li J, Yoo D, Rock D, Miller L, Lee C, Qi J, Du Y. (2021). Inhibition of antiviral innate immunity by foot-and-mouth disease virus Lpro through interaction with N-terminal domain of swine RNase L. Journal of Virology 95:e0036121.

Ke H, Han M, Kim J, Gustin KE, Yoo D. (2019). Porcine reproductive and respiratory syndrome virus nsp1-beta interaction with the nucleoporin 62 facilitates virus replication in vitro. Journal of Virology 93:e00469-19 

(Cover page article, Volume 93, Issue 14, July 15, 2019)

Hou Y, Ke H, Kim J, Yoo D, Su Y, Boley P, Saif LJ, Wang Q. (2019). Engineering an effective and safe live attenuated PEDV vaccine candidate via inactivation of the viral 2'-O methyltransferase and the endocytosis signal of the spike protein. Journal of Virology 93:e00406-19.

Zhang Q, Ke H, Blikslager A, Fujita T, Yoo D. (2018). Type III interferon restriction by porcine epidemic diarrhea virus and the role of viral protein nsp1 in IRF1 signaling. Journal of Virology 92:e01677-17.

Han M, Ke H, Zhang Q, Yoo D. (2017). Nuclear imprisonment of host cellular mRNA by nsp1ß protein of porcine reproductive and respiratory syndrome virus. Virology 505: 42-55 (Cover page article, Volume 505, May 2017).

Lee C, Hodgins DC, Calvert JG, Welch SK, Jolie R, Yoo D. (2006). Mutations in the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication. Virology 346:238-250 (Cover page article, Volume 346, Issue 1).