Professional Profile

• PhD, Microbiology, South Dakota State University, Brookings, SD
• MS, Entomology, Iowa State University, Ames, IA

• 2019-present – Professor, Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign
• 2016-2019 – Professor, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
• 2013-2016 – Associate Professor, Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University
• 2011-2013 – Associate Professor, joint appointment at Dept. of Veterinary and Biomedical Sciences / Dept. of Bio-Microbiology, South Dakota State University
• 2008-2011 – Assistant Professor, joint appointment at Dept. of Veterinary and Biomedical Sciences/Dept. of Bio-Microbiology, South Dakota State University
• 2005-2007 – Research Assistant Professor, Center for Infectious Disease Research and Vaccinology, Veterinary Sciences Department, South Dakota State University

• Dr. Fang has been deeply involved in the study of molecular pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV) for more than 20 years. Current research program is expending to other emerging/foreign viral pathogens. Her research interests have been focused on understanding the basic molecular mechanisms of viral pathogenesis, and applying the basic knowledge to develop strategies for the diagnoses, prevention and treatment of viral diseases. The laboratory has well established technologies and swine model system for vaccine and diagnostic assay development. Fang’s research has been supported by research grants from the US Department of Agriculture, National Institute of Health, National Pork Board and industry partners.

View Dr. Fang's publications in PubMed.

• 2017 Zoetis Animal Health Award for Research Excellence. Kansas State University
• 2013 Distinguished Researcher Award, South Dakota State University
• 2009 Intellectual Property Commercialization Award, South Dakota State University
• 2005 Dean’s Research Award, South Dakota State University
• 2004 Research Paper Award, South Dakota State University Chapter of the Society of Sigma Xi
• 2003 Graduate Student Travel Award, South Dakota State University
• 2000 VIIIth International Nidovirus Symposium Travel Award
• 1999 Research Proposal Award, South Dakota State University Chapter of the Society of Sigma Xi
• 1996 Professional Advancement Grant Award, Iowa State University

• Li Y, Firth AE, Brierley I, Cai Y, Napthine S, Wang T, Yan X, Kuhn JH, Fang Y*. 2019. Programmed -2/-1 Ribosomal Frameshifting in Simarteriviruses: An Evolutionarily Conserved Mechanism. J. Virol. 93(16). doi: 10.1128/JVI.00370-19.
• Petrovan V, Yuan F, Li Y, Shang P, Murgia MV, Misra S, Rowland RRR*, Fang Y*. 2019. Development and characterization of monoclonal antibodies against p30 protein of African swine fever virus. Virus Res. 269:197632. doi: 10.1016/j.virusres.2019.05.010.
• Guo R, Shang P, Carrillo CA, Sun Z, Lakshmanappa YS, Yan X, Renukaradhya GJ, McGill J, Jaing CJ, Niederwerder MC, Rowland RR, Fang Y*. 2018. Double-stranded viral RNA persists in vitro and in vivo during prolonged infection of porcine reproductive and respiratory syndrome virus. 2018, Virology, 524:78-89. doi: 10.1016/j.virol.2018.08.006. Virology Highlights paper.
• Guo R, Davis D, Fang Y*. 2018. Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus. Virology. 517:122-134. doi: 10.1016/j.virol.2017.12.018.
• Li Y, Shang P, Shyu D, Carrillo C, Naraghi-Arani P, Jaing CJ, Renukaradhya GJ, Firth AE, Snijder EJ, Fang Y*, 2018. Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses. Virology. 517:164-176. doi: 10.1016/j.virol.2017.12.017.
• Shang P, Misra S, Hause B*, Fang Y*. 2017. A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase. Journal of Virology, Jun 26;91(14). doi: 10.1128/JVI.00450-17. Spotlight Feature.
• Guo R, Katz BB, Tomich JM, Gallagher T, Fang Y*. 2016. Porcine Reproductive and Respiratory Syndrome Virus Utilizes Nanotubes for Intercellular Spread. J. Virol. 90(10):5163-75. doi: 10.1128/JVI.00036-16.
• Li Y, Shyu DL, Shang P, Bai J, Ouyang K, Dhakal S, Hiremath J, Binjawadagi B, Renukaradhya GJ*, Fang Y*. 2016. Mutations in a Highly Conserved Motif of nsp1β Protein Attenuate the Innate Immune Suppression Function of Porcine Reproductive and Respiratory Syndrome Virus. J. Virol. 90(7):3584-99. doi: 10.1128/JVI.03069-15.
• Chen Z, Yuan F, Li Y, Shang P, Schroeder R, Lechtenberg K, Henningson J, Hause B, Bai J, Rowland RR, Clavijo A, Fang Y*. 2016. Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A. Virology. 497:111-24. doi: 10.1016/j.virol.2016.07.003.
• McCormick K, Jiang Z, Zhu L, Lawson SR, Langenhorst R, Ransburgh R, Brunick C, Tracy MC, Hurtig HR, Mabee LM, Mingo M, Li Y, Webby RJ, Huber VC*, Fang Y.*. 2015. Construction and immunogenicity evaluation of recombinant influenza A viruses containing chimeric hemagglutinin genes derived from genetically divergent influenza H1N1 viruses. PLoS One. 10(6):e0127649. doi: 10.1371/journal.pone.0127649. eCollection 2015.
• Li Y, Tas A, Sun Z, Snijder EJ*, Fang Y*. 2014. Proteolytic Processing of Porcine Reproductive and Respiratory Syndrome Virus Replicase ORF1a Polyprotein. Virus Research, 111(21):E2172-81. doi: 10.1016/j.virusres.2014.12.027.
• Li Y, Treffers EE, Napthine S, Tas A, Zhu L, Sun Z, Bell S, Mark BL, van Veelen PA, van Hemert MJ, Firth AE, Brierley I*, Snijder EJ*, Fang Y*. 2014. Trans-activation of programmed ribosomal frameshifting by a viral protein. Proc Natl Acad Sci U S A. 111:E2171-81. doi: 10.1073/pnas.1321930111.
• Snijder EJ, Kikkert M, Fang Y. 2013. Arterivirus molecular biology and pathogenesis.
  J Gen Virol. Review. 94:2141-63.
• Li Y, Zhu L, Lawson SR, Fang Y*. 2013. Targeted mutations in a highly conserved motif of nsp1beta protein impair interferon antagonizing activity of porcine reproductive and respiratory syndrome virus. J Gen Virol. 94:1972-83.
• Sun Z, Lawson S, Langenhorst R, McCormick KL, Brunick C, Opriessnig T, Baker R, Yoon KJ, Zhang W, Huber VC, Fang Y*. 2013. Construction and immunogenicity evaluation of an epitope-based antigen against swine influenza A virus using Escherichia coli heat-labile toxin B subunit as a carrier-adjuvant. Vet. Microbiol. 164(3-4):229-38.
• Fang Y*, E. E. Treffers, Y. Li, A. Tas, Z. Sun, Y. van der Meer, A. H. de Ru, P. A. van Veelen, J. F. Atkins, E. J. Snijder*, A. E. Firth*. 2012. Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. Proc Natl Acad Sci U S A. 109(43):E2920-8.
• Sun, Z., V. Huber, K. McCormick, R. S. Kaushik, A. C. M. Boon, L. Zhu, B. Hause, R. J. Webby, Y. Fang*. 2012. Characterization of a porcine epithelial cell line for influenza virus production. J. Gen. Virology. 93(9):2008-16.
• Li, Y., A. Tas, E. J. Snijder*. Y. Fang*. 2012. Identification of Porcine Reproductive and Respiratory Syndrome Virus ORF1a-Encoded Nonstructural Proteins in Virus-Infected Cells. J. Gen. Virology. 93(4):829-39.
• Sun, Z., Y. Li, R. Ransburgh, E. J. Snijder, Y. Fang*. 2012. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. J. Virology. 86(7):3839-50.
• Langenhorst, R. J., S. Lawson, A. Kittawornrat, J. J. Zimmerman, Z. Sun, Y. Li, J. Christopher-Hennings, E. A. Nelson, Y. Fang*. 2011. Development of a fluorescent microsphere immunoassay for detection of antibodies against PRRSV using oral fluid samples as an alternative to serum-based assays. Clin Vaccine Immunol. 19(2):180-9.
• Fang, Y.*, and E. J. Snijder. 2010. The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Res. Review. 154(1-2):61-76.
• Sun, Z., Z. Chen, S. Lawson, Y. Fang*. 2010. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitination and interferon antagonism function. J. Virol. 84(15):7832-46.
• Chen, Z., S. Lawson, Z. Sun, X. Zhou, X. Guan, J. Christopher-Hennings, E. A. Nelson, Y. Fang*. 2010. Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology. 398 (1): 87-97.
• Chen, Z., X. Zhou, J. K. Lunney, S. Lawson, Z. Sun, E. Brown, J. Christopher-Hennings, D. Knudsen, E. Nelson, Y. Fang*. 2010. Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication but play an important role in modulation of host immune response. J. Gen. Virol. 91(4):1047-1057.
• Brown, E., S. Lawson, C. Welbon, M. P. Murtaugh, E. A. Nelson, J. J. Zimmerman, R. R. R. Rowland, Y. Fang*. 2009. Antibody response of nonstructural proteins: implication for diagnostic detection and differentiation of Type I and Type II porcine reproductive and respiratory syndrome virus. J. Clin. Vaccine Immunol. 16: 628-635.
• Fang, Y*., J. Christopher-Hennings, E. Brown, H. Liu, Z. Chen, S. Lawson, R. Breen, T. Clement, X. Gao, J. Bao, D. Knudsen, R. Daly, E. Nelson. 2008. Development of Genetic Markers in the Nonstructural Protein 2 Region of a US Type 1 Porcine Reproductive and Respiratory Syndrome Virus: Implications for Future Recombinant Marker Vaccine Development. J. Gen. Virology. 89:3086-3096.
• Fang, Y.*, Rowland, R. R., Roof, M., Lunney, J. K., Christopher-Hennings, J., and Nelson, E. A. 2006. A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the nsp2 region. J. Virology. 80(23):11447-11455.
• Fang, Y., D.-Y. Kim, S. Ropp, P. Steen, J. Christopher-Hennings, E.A. Nelson and R.R.R. Rowland. 2004. Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Virus Res. 100(2): 229-235.