Research


We study life forms from bacteria and fungi to humans and animals, as individuals and populations. Our research draws on disciplines from cell and molecular biology to epidemiology, applied medicine, and geospatial analysis.

[Fred Kummerow in his laboratory]
[swimming dolphin]
[3D depiction of the production of steroid hormones]
[graphic of mice and impact of BPA exposure over three generations]
[Pamela Wilkins and Maureen McMichael with a horse]
[Dr. Elizabeth Driskell and Clyde, a golden retriever, in an exam room]
[Dr. Jodi Flaws at a microscope]
[Three vaccine researchers in Russia]

Discovery at the College of Veterinary Medicine encompasses the spectrum of biomedical sciences.

The Office of Research and Advanced Studies provides assistance with grant writing, proposal preparation, research forms and protocols, and many other aspects of the research process and administers the joint DVM/PhD Veterinary Medical Scholars Program and the Summer Research Training Program for veterinary students.

Research and graduate education occur within the three academic departments, listed below, with guidance and support from the Office of Research and Advanced Studies.

To see the breadth of scholarly activity of college faculty, visit individual faculty biosketch pages or view the recent quarterly reports on grants, publications, presentations, and honors. Below is a sampling of recent grants and publications.

 

Selected Recent Grant Awards

Nutritional Enhancement of Learning and Memory in Low Birth Weight Neonates: a Small-For-Gestational-Age Piglet Model.

Johnson R, Lezmi S, $513,526, CNLM Abbott Nutrition.

Zoo Ready: National Emergency Preparedness and Functional Exercises of FAD Outbreak Response in Zoos and Aquariums.

Johnson Y, Miller GY, $116,000, USDA APHIS.

Graduate College – University of Illinois Focal Grant Proposal.

Damhorst G, Long K, McNamara P, Miller GY, $15,000, Illinois-Njala Global Health Partnership

Engineering Cytochrome P450s for Natural Product Biosynthesis.

Das A, $7,000, Manus Biosynthesis Boston.


Selected Recent Publications

Dermatophilus congolensis in a feral cat.

Barger AM, Weedon GR, Maddox CW, and Galloway KA. J Feline Med Surg. October 2014. Vol. 16, 10: pp. 840-841.

Serum amyloid A and haptoglobin concentrations are increased in plasma of mares with ascending placentitis in the absence of changes in peripheral leukocyte counts or fibrinogen concentration.

Canisso IF, Ball BA, Cray C, Williams NM, Scoggin KE, Davolli GM, Squires EL, Troedsson MH. Am J Reprod Immunol. 2014. 72:376-85.

In vitro cytotoxicity of lomustin and its metabolites on dog lymphocytes and hepatocytes.

Chakkath T, Lavergne SN, Fan T, Dirikolu L. J Vet Sci. 2014.1(3), 159-173; doi:10.3390/vetsci1030159

The Impact of Nuisance Flies on Growing Dairy Heifers.

Davis K, Blair B, Ramirez CR, French D. i-ACES 2014. 1(1):26-31

Measuring the level of agreement between cloacal gram stains and bacterial cultures in Hispanolan parrots (Amazona ventralis).

Evans E, Mitchell MA, Whittington JK, Roy A, Tully TN. J Avian Med Surg. 2014. 8(4):290-297.

Canine mast cell tumors: diagnosis, treatment, and prognosis.

Garrett LD. Veterinary Medicine: Research and Reports. 2014. Vol 2014:5: 49-58.

Biogenesis of non-structural protein 1 (nsp1) and nsp1-mediated type I interferon modulation in arteriviruses.

Han M, Kim CY, Rowland RRR, Fang Y, Kim D, Yoo D. Virology. 2014. 458-469:136-150.

2014. Mycoplasma pneumoniae modulates the STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins.

Hao Y, Kuang Z, Miao J, Krause DC, Lau GW. Infect Immun. 2014. 82: 5246-55.

Antibiotic stewardship in small animal medicine, are we there yet?

Lavergne SN. Adv Small Animal Med Surg, September; 27(9), 2014.

Endocannabinoids – Anandamide and 2- Arachidonoylglycerol are Substrates for Human Cytochrome P450 2J2 Epoxygenase.

McDougle D, Kambalayal A, Das, A. J Pharmacology and Experimental Therapeutics. 2014. DOI: 10.1124/jpet.114.216598.

Unveiling a novel role for the N-terminus of CYP in aiding electron transfer from CPR.

Meling D, and Das A. J Inorganic Biochem. 2014. DOI: 10.1016/j.jinorgbio.2014.09.016.

Cerebral and ocular ochoconiasis in 2 elegant crested tinamou (Eudromia elegans) chicks.

Ossiboff RJ, Clancy MM, Terio KA, Conley KJ, McAloose D. Vet Path. 2014. 10.1177/0300985814556186.

Barbed versus smooth poly-propylene three-loop pulley sutures for repair of canine gastrocnemius tendon.

Perry BS, Harper TA, Mitchell MA, McFadden MS, Heggem Perry B. Vet Comp Orthop Traumatol. 2014. 27(6): 436-440.

Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood.

Poon E, Bandara, S Allen, J Sadowski, R. and Schantz SL. Neurotoxicology. 2014. 46:117-124.

Management of a High-Risk Newborn Calf.

Ramirez CR, and Aldridge BM. ISVMA Epitome. 2015; Winter: pp. 14-16.

Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females.

Sadowski RN, Wise LM, Park PY, Schantz SL, Juraska JM. Neuroscience. 2014. 279:122-31.

Gross and histopathologic correlation of low-field magnetic resonance imaging findings in the stifle of asymptomatic horses.

Santos MP, Gutierrez-Nibeyro SD, McKnightn AL, Singh K. Vet Radiol Ultrasound. December 28, 2014. doi: 10.1111/vru.12233.

Outcome and prognostic factors for osteosarcoma of the head in dogs: 183 cases (1987-2010).

Selmic LE, Beckwith K, Lafferty M, Kamstock D, Garner A, Ehrhart NP, Worley DR, Withrow SJ, Lana SE. J Am Vet Med Assoc. 2014. 245(8):930–938.

Expression of nociceptive ligands in canine osteosarcoma.

Shor S, Fadl-Alla B, Pondenis H, Zhang X, Wycislo K, Lezmi S, Fan T. J. Vet. Int. Med. 2014.

Expression of receptors for ovarian steroids and prostaglandin E2 in the endometrium and myometrium of mares during estrus, diestrus and early pregnancy.

Silva ES, Scoggin KE, Canisso IF, Troedsson MH, Squires EL, Ball BA. Anim Reprod Sci. 2014. 151:169-181.

Human metapneumovirus infection in chimpanzees, United States.

Slater OM, Terio KA, Zhang Y, Erdman DD, Schneider E, Kuypers JM, Kunstman KJ, Kunstman J, Kinsel MJ, Gamble KC. Emerg Infect Diseases . 2014. 20(12): 2115-8.

Pancreatic Carcinoma in an African Clawed Frog (Xenopus laevis).

Stern AW, Allison S, Chu C. Comp Med. 2014. 64(6):421-423.

Investigating the optimal size of anticancer nano-medicine.

Tang L, Yang X, Yin Q, Cai K, Wang H, Chaudhury I, Yao C, Zhou Q, Kwon M, Hartman J, Dobrucka I, Dobrucki L, Borst L, Lezmi S, Helferich W, Ferguson A, Fan T, Cheng J. PNAS. 2014. 111:15344-9.

Evaluating the clinical and physiological effects of long term ultraviolet B Radiation on guinea pigs (Cavia porcellus).

Watson MK, Stern AW, Labelle AL, Joslyn S, Fan TM, Leister K, Kohles M, Marshall K, Mitchell MA. PLoS One: 2014. 9(12):e114413.

Canine progenitor epidermal keratinocytes (CPEK) express various inflammatory markers among which interleukin-8 and CD40 are affected by certain antibiotics.

White AE, Wolsic C, Campbell KL, Lavergne SN. Vet Dermatol. 2014. December (6):493-502.

In vitro re-expression of the aryl hydrocarbon receptor into Ahr-deficient mouse antral follicles partially restores the phenotype to that of wild-type mice.

Ziv-Gal A, Gao L, Karman BN, Flaws JA. Tox In Vitro. 2015. 29:329-36.