Professional Profile

image for Matsumoto, Masa

Matsumoto, Masa

Assistant Professor

Department of Pathobiology
2001 South Lincoln Ave.
2001 S Lincoln
M/C 002
Urbana, IL  61802

show listEducation

  • PhD, Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan (Advisor: Dr. Masayuki Miyasaka
  • MS, Microbiology and Immunology, Osaka University Graduate School of Medicine, Osaka, Japan (Advisor: Dr. Masayuki Miyasaka)
  • BS, Biotechnology, Ritsumeikan University, Shiga, Japan

show listAcademic Positions

  • Postdoctoral Fellow, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI (Mentor: Dr. Gabriel Nunez)
  • Postdoctoral Fellow, Immunology Frontier Research Center, Osaka University, Osaka, Japan (Mentor: Dr. Tomohiro Kurosaki)

show listResearch Interests

  • Our laboratory focuses on the mechanisms by which the pathogen Staphylococcus aureus induces skin inflammation. In particular, to understand the roles of S. aureus and immune cells in atopic dermatitis (AD), a common inflammatory skin disease, we are conducting experiments using our recently developed mouse model of epicutaneous infection with S. aureus. This study may lead to important insights into the etiology of AD that will help in the development of new therapeutic approaches for AD patients.

show listLinks

show listGrants

  • Current:
    • NIH/NIAMS K01AR078931-01A1 (Role: PI) 06/01/2022-05/31/2027. Understanding the role of S. aureus Agr virulence in atopic dermatitis (AD).
  • Completed:
    • NIH/NIAMS P30AR075043 (Role: PI) 06/01/2022-05/31/2023. Understanding the role of neutrophil type I interferon signaling in S. aureus-induced skin inflammation 

show listHonors and Awards

  • American Association of Immunologists (AAI) Early Carrer Faculty Travel Grant, IMMUNOLOGY2024, AAI, 2024 
  • United Japanese researchers Around the world (UJA) Outstanding Research Paper Award, 2022 
  • Best Presentation Award, TOLL 2018 meeting, 2018 
  • Postdoctoral Fellowship, The Uehara Memorial Foundation, 2016 
  • Postdoctoral Fellowship, Mochida Memorial Foundation for Medical and Pharmaceutical Research, 2016 
  • Best Presentation Award, Signal Network Meeting of Japan, 2014 
  • Postdoctoral Fellowship, Japanese Society for the Promotion of Science (JSPS), 2007 
  • Encouraging Prize for Excellent Research from the Research Foundation for the Microbial Diseases of Osaka University, 2006 

show listSelected Publications

  1. Lo B., Yu J., Vatan L., Caruso R., Matsumoto M., Sato Y., Shaw M., Inohara N., Xie Y., Lei Y., Zou W. and Nunez G. Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fc receptors. Science, 303: 62-70, 2024. 
  2. Yada Y.*, Matsumoto M.*, Inoue T., Baba A., Kitamura D., Ohga S., Kurosaki T. and Baba Y. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J. Exp. Med., 221: e20222178, 2024. 
  3. Matsumoto M.#, Nakagawa S., Zhang L., Nakamura Y., Villaruz A., Otto M., Wolz C., Inohara N. and Nunez G.# Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin. Cell Host & Microbe, 29:1-11, 2021. 
  4.  Nakagawa S.*, Matsumoto M.*, Katayama Y., Oguma R., Wakabayashi S., Nygaard T., Saijo S., Inohara N., Otto M., Matsue H., Nunez G. and Nakamura Y. Staphylococcus aureus virulent PSM peptides induce keratinocyte alarmin release to orchestrate IL-17-dependent skin inflammation. Cell Host & Microbe, 22:667-677, 2017. 
  5. Matsumoto M., Baba A., Yokota T., Nishikawa H., Ohkawa Y., Kayama H., Kallies A., Nutt S.L., Sakaguchi S., Takeda K., Kurosaki T. and Baba Y. Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity, 41:1040-1051, 2014.
  6. Matsumoto M., Fujii Y., Baba A., Hikida M., Kurosaki T. and Baba Y. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity, 34:703-714, 2011. 
     
     (*Co-first author, # Co-corresponding author)