Lab Publication
“Editorial: Environmental Factors Influencing the Immune Functions During Multiple Sclerosis” was published in the Frontiers in Immunology. Read more at DOI: doi:10.3389/fimmu.2023.1141014
New member of Inoue Lab: Joshua Saylor, an NSP Ph.D. student
Welcome, Josh!
New member of Inoue Lab: Jinyan Zhou, an NSP Ph.D. student
Welcome, Jinyan!
Rachel defended her thesis!
Rachel successfully defended her thesis entitled "Assessment of the Impact of Early Life Stress, Changes in Estrogen Signaling, and Neurotoxic Molecules on Disease Phenotype in a Murine Model of Multiple Sclerosis" on 11/08/21. Congratulations Rachel!
Makoto won Zoetis Award!
Makoto received Zoetis Award for Research Excellence for the University of Illinois College of Veterinary Medicine. Congratulations Makoto!
Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by [...]
Immune regulation of CNS dysfunction in Cryptococcus-associated Immune Reconstitution Inflammatory Syndrome (C-IRIS)
Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes [...]