Rachel successfully defended her thesis entitled "Assessment of the Impact of Early Life Stress, Changes in Estrogen Signaling, and Neurotoxic Molecules on Disease Phenotype in a Murine Model of Multiple Sclerosis" on 11/08/21. Congratulations Rachel!
Rachel participated in the Vet Med's annual Celebration of Research with her poster on the topic of "Impact of Early Like Trauma on Autoimmune Disease Phenotype and Development via Dysregulated β1 Adrenergic Signaling". Her poster won honorable mention with the prize of $500 for research use. Congratulations Rachell!
Inoue lab's fourth year neuroscience graduate student won the 2021 C. Ladd Prosser award which recognizes the research contribution of a Graduate Student that stands out as THE BEST SCIENTIFIC ACHIEVEMENT with THE BROADEST SIGNIFICANCE for the discipline of neuroscience. Congratulations Rachel!
Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by [...]
Our paper “Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis” was published in PNAS. Read more at DOI: https://doi.org/10.1073/pnas.2017213118
Our recently published work on the impact of early life trauma on an animal model of multiple sclerosis is featured in the news by UIUC News Bereau. Read news story: https://news.illinois.edu/view/6367/530521238 Read published article: https://www.nature.com/articles/s41467-020-20302-0
Rachel (Yee Ming) passed her preliminary exam on the 6th of January, 2021 and is now a PhD candidate. Congratulations Rachel!
Immune regulation of CNS dysfunction in Cryptococcus-associated Immune Reconstitution Inflammatory Syndrome (C-IRIS)
Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes [...]
Our paper “Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling" was published in Nature Communications, 12(1), 105, in January 2021. Read more: https://www.nature.com/articles/s41467-020-20302-0
Our paper “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficient in an animal model of multiple sclerosis” was published in Biomaterials Science. This work was featured on the cover of Biomaterials Science, Volume 8, Number 19, October 2020. Read more: https://pubs.rsc.org/en/content/articlelanding/2020/BM/D0BM00957A#!divAbstract