Our Nature Communications paper “T cell infiltration into the brain triggers pulmonary dysfunction in murine Cryptococcus-associated IRIS”is published online. To read more, please visit: https://doi.org/10.1038/s41467-023-39518-x

2023-07-18T20:43:35-05:00July 18th, 2023|Uncategorized|

Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis

Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by [...]

2021-03-31T21:16:05-05:00March 31st, 2021|Uncategorized|

Immune regulation of CNS dysfunction in Cryptococcus-associated Immune Reconstitution Inflammatory Syndrome (C-IRIS)

Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes [...]

2021-01-08T23:11:33-06:00January 8th, 2021|Uncategorized|
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