Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by [...]
Our paper “Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis” was published in PNAS. Read more at DOI: https://doi.org/10.1073/pnas.2017213118
Our recently published work on the impact of early life trauma on an animal model of multiple sclerosis is featured in the news by UIUC News Bereau. Read news story: https://news.illinois.edu/view/6367/530521238 Read published article: https://www.nature.com/articles/s41467-020-20302-0
Rachel (Yee Ming) passed her preliminary exam on the 6th of January, 2021 and is now a PhD candidate. Congratulations Rachel!
Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes [...]
Our paper “Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling" was published in Nature Communications, 12(1), 105, in January 2021. Read more: https://www.nature.com/articles/s41467-020-20302-0
Our paper “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficient in an animal model of multiple sclerosis” was published in Biomaterials Science. This work was featured on the cover of Biomaterials Science, Volume 8, Number 19, October 2020. Read more: https://pubs.rsc.org/en/content/articlelanding/2020/BM/D0BM00957A#!divAbstract
Our paper "Th1-Dependent Cyptococcus-Associated Immune Reconstitution Inflammatory Syndrome Model with Brain Damage" was published in Frontiers in Immunology. Read more at DOI: 10.3389/fimmu.2020.529219
In the Fall of 2020, we welcome two new lab members: Visiting Scholar: Dr. Tasuku Kawano (Tohoku Medical and Pharmaceutical University) NSP Ph.D. Student: Ashley Otero Welcome Tasuku and Ashley!
Our paper "Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis" was published in Journal of Neuroinflammation. Volume 17, page 1-12. DOI: https://doi.org/10.1186/s12974-020-1730-y