Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes similar to human C-IRIS symptoms, such as systemic upregulation of some inflammatory cytokines and brain edema.
Read more: https://www.frontiersin.org/articles/10.3389/fimmu.2020.529219/full