The long-term objective of our laboratory research is to elucidate the molecular mechanism of ovulation, the process of egg release from the ovary. The program of ovulation is activated by a surge of pituitary luteinizing hormone that initiates dramatic changes in molecular, biochemical, and physical events in the ovary, eventually expelling eggs from the ovary. Ovulatory failure has been associated with the development of numerous ovarian disorders such as polycystic ovarian syndrome (PCOS), hemorrhagic cyst formation, hormonal imbalance and infertility, all of which are major risk factors for women’s health. My laboratory’s current research is focusing on the following areas: endothelin system in ovulation and luteal function, steroids and prostaglandins in leukocyte trafficking, steroid receptors in PCOS pathogenesis and reproductive aging. We generate transgenic animal models and used them for those projects. Once noble findings are made from the animal studies, molecular mechanisms behind are sought using in vitro experiments. Routinely applied skills/approaches include but not limited to tissue specific gene targeting, microsurgery, organ transplantation, fertility test, histology, immunohistochemistry, hormone assays, DNA microarray, real-time PCR, tissue culture, and bioinformatics. The ultimate research goal of our lab is to help women who suffer from reproductive disorders and to develop safe and effective contraceptive strategies for humans and animals.

News

Congratulations! The Endocrine Society has selected Arnon Gal’s abstract for one of the Endocrine Society Outstanding Abstract Awards in conjunction with ICE/ENDO 2014 in Chicago. The Society will recognize him and the other Outstanding Abstract Award winners during the morning plenary session on Tuesday, June 24 at 8:00 am. Arnon has has successfully defended his doctoral dissertation on March 21, 2014, and there will be a celebration party on May 16 at Dr. Ko’s. His doctoral degree will officially be awarded at the 2014 commencement ceremony on May 17th, 2014.”