Publications 2017-09-15T16:05:59+00:00


(PubMed Listings for Sumiti Vinayak)

  • Manjunatha UH*, Vinayak S*, Sy T, Chao AT, Noble CG, Bonamy G, Brooks CF, Herbert GT, Sateriale A, Tandel J, Kondreddi RR, Noh S, Zou B, Gedeck P, Lakshminarayana SB, Blasco F, Lim SH, Goodman LB, Yeung BKS, Bodenreider C, Simon O, Feng G, Wagner J, Leong FJ, Zambriski JA, Striepen B, Diagana TT. A Cryptosporidium PI(4)K inhibitor is a drug candidate for pediatric cryptosporidiosis. Nature 2017, 546: 376-380 (* Equal contribution)​.

    Research highlighted in:

    Nature Reviews Gastroenterology and Hepatology.
    Nature Drug Discovery
    Trends in Parasitology

  • Hulverson MA*, Vinayak S*, Choi R, Schaefer DA, Castellanos-Gonzalez A, Vidadala RSR, Brooks CF, Betzer DP, Whittman GR, Sparks HN, Arnold SLM, Rivas KL, Barrett LK, White AC, Maly DJ, Riggs MW, Striepen B, Voorhis WV, Ojo KK. Bumped-kinase inhibitors for the therapy of Cryptosporidiosis. Journal of Infectious Diseases 2017, 215: 1275-1284 (* Equal contribution)
  • Pawlowic MC, Vinayak S, Sateriale A, Brooks C, Striepen B. Generating and maintaining transgenic parasites. Current Protocols in Microbiology 46: 20B.2.1-20B.2.32
  • Arnold SLM *, Choi R, Hulverson MA, Schaefer DA, Vinayak S, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Maly DJ, Riggs MW, Striepen B, Voorhis WV. Necessity of bumped kinase inhibitor gastrointestinal exposure in treating Cryptosporidium infection. Journal of Infectious Diseases 2017, 216: 55-63
  • Vinayak S*, Pawlowic MC*, Sateriale A*, Brooks CF, Studstill CJ, Bar-Peled Y, Cipriano MJ, Striepen B. Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum. Nature 2015; 523:477-480 (* Equal contribution).

    Research highlighted in:

    Nature Reviews Genetics
    Trends in Parasitology

  • Vinayak S, Brooks CF, Naumov A, Suvorova ES, White MW, Striepen B. Genetic manipulation of Toxoplasma gondii genome using fosmid recombineering. mBio 2014; 5.pii:e02021-14
  • Suvorova ES, Radke JB, Ting LM, Vinayak S, Kratzer S, Striepen B, White MW. A nucleolar AAA-NTPase is required for parasite division. Molecular Microbiology 2013; 90:338-355
  • Zeeshan M, Alam MT, Vinayak S, Bora H, Tyagi RK, Alam MS, Choudhary V, Mittra P, Lumb V, Bharti PK, Udhayakumar V, Singh N, Jain V, Singh PP, Sharma YD. Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine. PLoS One 2012; 7:e43430
  • Alam MT, de Souza DK, Vinayak S, Griffing SM, Poe AC, Duah N, Ghansah A, Asamoa K, Slutsker L, Wilson MD, Barnwell JW, Udhayakumar V, Koram KA. Selective sweeps and genetic backgrounds of Plasmodium falciparum drug resistance mutations in Ghana. Journal of Infectious Diseases 2011; 203:220-227
  • Alam MT, Vinayak S, Congpuong K, Wongsrichanalai C, Satimai W, Slutsker L, Escalante AA, Barnwell JW, Udhayakumar V. Tracking the origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in Thailand. Antimicrobial Agents and Chemotherapy 2011; 55:155-164
  • Vinayak S*, Alam MT*, Mixson-Hayden T, McCollum AM, Sem R, Shah NK, Lim P, Muth S, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V. Origin and evolution of sulfadoxine resistant Plasmodium falciparum. PLoS Pathogens2010; 6:e1000830 (* Equal contribution)
  • Griffing S, Syphard L, Sridaran S, McCollum AM, Mixson-Hayden T, Vinayak S, Villegas L, Barnwell JW, Escalante AA, Udhayakumar V. Pfmdr1 amplification and fixation of chloroquine resistant pfcrt alleles in Venezuela. Antimicrobial Agents and Chemotherapy 2010; 54:1572-1579
  • Vinayak S, Alam MT, Sem R, Shah NK, Susanti AI, Lim P, Muth S, Maguire JD, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V. Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia. Journal of Infectious Diseases 2010; 201:1551-1560 (Cover Page Article)
  • Congpuong K, Saipomsud W, Chompoonuch C, Niemhom P, Vinayak S, Satimai W. Efficacy of a 3-day artesunate-mefloquine combination in the treatment of uncomplicated falciparum malaria in Kanchanaburi province of Thailand. Asian Biomedicine 2010; 4:289-295
  • Vinayak S, Rathore D, Kariuki S, Slutsker L, Shi YP, Villegas L, Escalante AA, Udhayakumar V. Limited genetic variation in the Plasmodium falciparum heme detoxification protein (HDP). Infection Genetics and Evolution 2008; 9:286-289
  • Vinayak S, Alam MT, Upadhyay M, Das MK, Dev V, Singh N, Dash AP, Sharma YD. Extensive genetic diversity in the Plasmodium falciparumNa+/H+ exchanger-1 transporter protein implicated in quinine resistance. Antimicrobial Agents and Chemotherapy 2007; 51:4508-4511
  • Vinayak S, Sharma YD. Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme. Oligonucleotides 2007; 17:189-200
  • Vinayak S, Mittra P, Sharma YD. Wide variation in microsatellite sequences within each Pfcrt mutant haplotype. Molecular and Biochemical Parasitology 2006; 147:101-108
  • Mittra P, Vinayak S, Chandawat H, Das MK, Singh N, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Progressive increase in point mutations associated with chloroquine resistance in Plasmodium falciparum isolates from India. Journal of Infectious Diseases 2006; 193:1304-1312
  • Ahmed A, Bararia D, Vinayak S, Yameen M, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance. Antimicrobial Agents and Chemotherapy 2004; 48:879-889
  • Vinayak S, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Prevalence of the K76T mutation in the pfcrt gene of Plasmodium falciparum among chloroquine responders in India. Acta Tropica 2003; 87:287-293