How is information processing regulated with neural circuits and how does imbalance in neuromodulators and excitation/inhibition contribute to neuropsychiatric illness? Imbalances between excitation and inhibition (E/I) represent a common pathological feature in neurodevelopmental and neurodegenerative disorders such as Parkinson’s Disease and Autism. A variety of genetically distinct disease models commonly share imbalanced synaptic conductance ratios and abnormal brain oscillations. Despite the shared prevalence of E/I imbalance, abnormal rhythms, and the presence of motor, social, or cognitive deficits, there is no underlying unifying theory to connect these features. Our lab is interested in identifying the mechanistic foundation of imbalance and how does imbalance contribute to cognitive or behavioral deficits using high density recordings from known cell types across aging and disease.