PUBLICATIONS

  • Wang, B, Tontonoz, P. Phospholipid Remodeling in Physiology and Disease. Annu Rev Physiol. 2019 Feb 10;81:165-188.
  • Wang, B, Tontonoz, P. Liver X receptors in lipid signaling and membrane homeostasis. Nat Rev Endocrinol. 2018;14: 452–463.
  • Wang, B., Rong, X., Palladino, E.N., Wang, J., Fogelman, A.M., Martin, M.G., Alrefai, W.A., Ford, D.A., Tontonoz, P. Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis. Cell Stem Cell. 2018;22(2):206-220.
  • Rong, X., Wang, B., Palladino, E.N., Vallim, T., Ford, D.A., Tontonoz, P. ER Phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin. Invest. 2017;127(10):3640-3651.
  • Wang, B., Rong, X., Duerr, M.A., Hermanson, D.J., Hedde, P.N., Wong, J.S., de Aguiar Vallim, T.Q., Cravatt, B.F., Gratton, E., Ford, D.A., Tontonoz, P. Intestinal phospholipid remodeling is required for dietary lipid uptake and survival on a high-fat diet. Cell Metab. 2016; 23 (3), 492-504.
  • Rong, X., Wang, B., Dunham, M.M., Hedde, P.N., Wong, J.S., Gratton, E., Young, S.G., Ford, D.A., Tontonoz, P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. 2015 Mar 25;4. doi: 10.7554/eLife.06557.
  • Wang, B., Hsu, S.H., Wang, X., Kutay, H., Bid, H.K., Yu, J., Ganju, R.K., Jacob, S.T., Yuneva, M., Ghoshal, K. Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. Hepatology. 2014; 59(2):555-66.
  • Rong, X., Albert, C.J., Hong, C., Duerr, M.A., Chamberlain, B.T., Tarling, E.J., Ito, A., Gao, J., Wang, B., Edwards, P.A., Jung, M.E., Ford, D.A., Tontonoz, P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013;18(5):685-97.
  • Hsu, S.H., Wang, B., Kutay, H., Bid, H., Shreve, J., Zhang, X., Costinean, S., Bratasz,, A., Houghton, P., Ghoshal, K. Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. Am J Pathol. 2013; 183(6):1719-30.
  • Hsu, S.H.*, Wang, B.*, Kota, J.*, Yu, J.*, Costinean, S.*, Kutay, H.*, Yu, L.*, Bai, S.*, Perle, K.L., Chivukula, R.R., Mao, H., Wei, M., Clark, R., Mendell, J.R., Caligiuri, M.A., Jacob, S.T., Mendell, J.T., and Ghoshal, K. Essential metabolic, anti-inflammatory and anti-tumorigenic functions for miR-122 in mouse liver. J Clin. Invest. 2012; 122(8):2871-83. * Equal contribution
  • Wang, B., Hsu, S.H., Frankel, W., Ghoshal, K., Jacob, S.T. Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1α. Hepatology. 2012; 56(1):186-97.
  • Wang, B., Hsu, S.H., Majumder, S., Kutay, H., Huang, W., Jacob, S.T., Ghoshal, K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. 2010; 29(12):1787-97.
  • Wang, B., Majumder, S., Nuovo, G., Kutay, H., Volinia, S., Patel, T., Schmittgen, T.D., Croce, C., Ghoshal, K., Jacob, S.T. Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology. 2009; 50(4):1152-61.
  • Bai, S.*, Nasser, M.W.*, Wang, B.*, Hsu, S.H., Datta, J., Kutay, H., Yadav, A., Nuovo, G., Kumar, P., Ghoshal, K. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem. 2009; 284 (46):32015-27. * Equal contribution
  • Datta, J., Kutay, H., Nasser, M.W., Nuovo, G.J., Wang, B., Majumder, S., Liu, C.G., Volinia, S., Croce, C.M., Schmittgen, T.D., Ghoshal, K., Jacob, S.T. Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res. 2008; 68(13):5049-58.
  • Chen, M.H., Zhang, L.S., Zhang, H.Y., Xiong, X.H., Wang, B., Lu, B., Wahlestedt, C., Liang, Z.C. A Universal Plasmid Library Encoding All Permutations of siRNA. Natl. Acad. Sci.USA 2005; 102 (7): 2356-2361.