PUBLICATIONS

  • Ruicheng Shi, Wei Lu, Ye Tian, Wang B. Intestinal SEC16B modulates obesity by regulating chylomicron metabolism. Molecular Metabolism. 2023, 70:101693.
  • Tian Y, Mehta K, Seok SM, Jellinek MJ, Kuo, S, Lu W, Shi R, Ingram K, Lau G, Kemper JK, Ford DA, Zhang K, Wang B. Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis. Hepatology, 2023 April 3. DOI: 10.1097/HEP.0000000000000375.
  • Wang, B, Tontonoz, P. Phospholipid Remodeling in Physiology and Disease. Annu Rev Physiol. 2019 Feb 10;81:165-188.
  • Wang, B, Tontonoz, P. Liver X receptors in lipid signaling and membrane homeostasis. Nat Rev Endocrinol. 2018;14: 452–463.
  • Wang, B., Rong, X., Palladino, E.N., Wang, J., Fogelman, A.M., Martin, M.G., Alrefai, W.A., Ford, D.A., Tontonoz, P. Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis. Cell Stem Cell. 2018;22(2):206-220.
  • Rong, X., Wang, B., Palladino, E.N., Vallim, T., Ford, D.A., Tontonoz, P. ER Phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin. Invest. 2017;127(10):3640-3651.
  • Wang, B., Rong, X., Duerr, M.A., Hermanson, D.J., Hedde, P.N., Wong, J.S., de Aguiar Vallim, T.Q., Cravatt, B.F., Gratton, E., Ford, D.A., Tontonoz, P. Intestinal phospholipid remodeling is required for dietary lipid uptake and survival on a high-fat diet. Cell Metab. 2016; 23 (3), 492-504.
  • Rong, X., Wang, B., Dunham, M.M., Hedde, P.N., Wong, J.S., Gratton, E., Young, S.G., Ford, D.A., Tontonoz, P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. 2015 Mar 25;4. doi: 10.7554/eLife.06557.
  • Wang, B., Hsu, S.H., Wang, X., Kutay, H., Bid, H.K., Yu, J., Ganju, R.K., Jacob, S.T., Yuneva, M., Ghoshal, K. Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. Hepatology. 2014; 59(2):555-66.
  • Rong, X., Albert, C.J., Hong, C., Duerr, M.A., Chamberlain, B.T., Tarling, E.J., Ito, A., Gao, J., Wang, B., Edwards, P.A., Jung, M.E., Ford, D.A., Tontonoz, P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013;18(5):685-97.
  • Hsu, S.H., Wang, B., Kutay, H., Bid, H., Shreve, J., Zhang, X., Costinean, S., Bratasz,, A., Houghton, P., Ghoshal, K. Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. Am J Pathol. 2013; 183(6):1719-30.
  • Hsu, S.H.*, Wang, B.*, Kota, J.*, Yu, J.*, Costinean, S.*, Kutay, H.*, Yu, L.*, Bai, S.*, Perle, K.L., Chivukula, R.R., Mao, H., Wei, M., Clark, R., Mendell, J.R., Caligiuri, M.A., Jacob, S.T., Mendell, J.T., and Ghoshal, K. Essential metabolic, anti-inflammatory and anti-tumorigenic functions for miR-122 in mouse liver. J Clin. Invest. 2012; 122(8):2871-83. * Equal contribution
  • Wang, B., Hsu, S.H., Frankel, W., Ghoshal, K., Jacob, S.T. Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1α. Hepatology. 2012; 56(1):186-97.
  • Wang, B., Hsu, S.H., Majumder, S., Kutay, H., Huang, W., Jacob, S.T., Ghoshal, K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. 2010; 29(12):1787-97.
  • Wang, B., Majumder, S., Nuovo, G., Kutay, H., Volinia, S., Patel, T., Schmittgen, T.D., Croce, C., Ghoshal, K., Jacob, S.T. Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology. 2009; 50(4):1152-61.
  • Bai, S.*, Nasser, M.W.*, Wang, B.*, Hsu, S.H., Datta, J., Kutay, H., Yadav, A., Nuovo, G., Kumar, P., Ghoshal, K. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem. 2009; 284 (46):32015-27. * Equal contribution
  • Datta, J., Kutay, H., Nasser, M.W., Nuovo, G.J., Wang, B., Majumder, S., Liu, C.G., Volinia, S., Croce, C.M., Schmittgen, T.D., Ghoshal, K., Jacob, S.T. Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res. 2008; 68(13):5049-58.
  • Chen, M.H., Zhang, L.S., Zhang, H.Y., Xiong, X.H., Wang, B., Lu, B., Wahlestedt, C., Liang, Z.C. A Universal Plasmid Library Encoding All Permutations of siRNA. Natl. Acad. Sci.USA 2005; 102 (7): 2356-2361.