PUBLICATIONS

  1. *Volkening J, Spatz SJ, Ponnuraj N, Akbar H, Arrington JV, Jarosinski KW. Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host. PLoS Pathog. 2023; 19(6): e11011204. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011204
  2. *Tien, YT, Akbar H, Jarosinski KW. 2023. Temperature-induced reactivation of Marek’s disease virus-transformed T cells ex vivo. Front Vet Sci. 10:1145757. https://doi.org/10.3389/fvets.2023.1145757
  3. *Ponnuraj, N, Akbar H, Arrington JV, Spatz SJ, Nagarajan B, Desai UR, Jarosinski KW. 2023. The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK). PLoS Pathog. 19(2): e1010959. https://doi.org/10.1371/journal.ppat.1010959
  4. *Akbar H, Fasick JJ, Ponnuraj N, Jarosinski KW. 2023. Purinergic signaling during Marek’s disease in chickens. Sci Rep. 13(1);2044. https://doi.org/10.1038/s41598-023-29210-x
  5. *Xu H, Krieter AL, Ponnuraj N, Tien YT, Kim T, Jarosinski KW. 2022. Coinfection in the host can result in functional complementation between live vaccines and virulent virus. Virulence. 13(1);980. https://doi.org/10.1080/21505594.2022.2082645
  6. *Krieter A, Xu H, Akbar H, Kim T, Jarosinski KW. 2022 The conserved Herpesviridae protein kinase (CHPK) of Gallid alphaherpesvirus 3 (GaHV3) in required for horizontal spread and natural infection in chickens. Viruses. 14(3):586. https://doi.org/10.3390/v14030586
  7. Gatherer D, Depledge DP, Hartley CA, Szpara ML, Vaz PK, Benkő M, Brandt CR, Bryant NA, Dastjerdi A, Doszpoly A, Gompels UA, Inoue N, Jarosinski KW, Kaul R, Lacoste V, Norberg P, Origgi FC, Orton RJ, Pellett PE, Schmid DS, Spatz SJ, Stewart JP, Trimpert J, Waltzek TB, Davison AJ. 2021. ICTV virus taxonomy profile: Herpesviridae J Gen Virol 102(10):001673. https://doi.org/10.1099/jgv.0.001673
  8. *Vega-Rodriguez W, Ponnuraj N, Garcia M, Jarosinski KW. 2021. The requirement of glycoprotein C for interindividual spread is functionally conserved within the Alphaherpesvirus genus (Mardivirus), but not the host (Gallid). Viruses 13(8):1419. https://doi.org/10.3390/v13081419
  9. *Vega-Rodriguez W, Xu H, Ponnuraj N, Akbar H, Kim T, Jarosinski KW. 2021. The requirement of glycoprotein C (gC) for interindividual spread is a conserved function of gC for avian herpesviruses. Sci Rep 11(1):7753. https://doi.org/10.1038/s41598-021-87400-x
  10. *Krieter A, Ponnuraj N, Jarosinski KW. 2020. Expression of the conserved herpesvirus protein kinase (CHPK) of Marek’s disease alphaherpesvirus in the skin reveals a mechanistic importance for CHPK during interindividual spread in chickens. J Virol 94:e01522-01519. https://doi.org/10.1128/JVI.01522-19
  11. Girsch JH, Jackson W, Carpenter JE, Moninger TO, Jarosinski KW, Grose C. 2020. Exocytosis of progeny infectious varicella-zoster virus particles via a mannose-6-phosphate receptor pathway without xenophagy following secondary envelopment. J Virol 94: e00800-00820. https://doi.org/10.1128/jvi.00800-20
  12. Burrell CE, Anchor C, Ahmed N, Landolfi J, Jarosinski KW, Terio KA. 2020. Characterization and comparison of SLAM/CD150 in free-ranging coyotes, raccoons, and Skunks in Illinois for Elucidation of Canine Distemper Virus Disease. Pathogens 9:e510. https://doi.org/10.3390/pathogens9060510
  13. *Vega-Rodriguez W, Ponnuraj N, Jarosinski KW. 2019. Marek’s disease alphaherpesvirus (MDV) RLORF4 is not required for expression of glycoprotein C and interindividual spread. Virology 534:108-113. https://doi.org/10.1016/j.virol.2019.06.008
  14. *Ponnuraj N, Tien YT, Vega-Rodriguez W, Krieter A, Jarosinski KW. 2019. The Herpesviridae conserved multifunctional infected-cell protein 27 (ICP27) is important but not required for replication and oncogenicity of Marek’s disease alphaherpesvirus. J Virol 93:e01903-01918. https://doi.org/10.1128/jvi.01903-18
  15. Jarosinski KW, Carpenter JE, Buckingham EM, Jackson W, Knudtson K, Moffat JF, Kita H, Grose C. 2018. Cellular stress response to varicella-zoster virus infection of human skin includes highly elevated interleukin-6 expression. Open Forum Infect Dis 5:ofy118. https://doi.org/10.1093/ofid/ofy118
  16. *Jarosinski KW. Interindividual Spread of Herpesviruses. In: Cell Biology of Herpes Viruses, Adv Anat Embryol Cell Biol 223:195-224. https://doi.org/10.1007/978-3-319-53168-7_9
  17. Buckingham EM, Jarosinski KW, Jackson W, Carpenter JE, Grose C. 2016. Exocytosis of varicella-zoster virus virions involves a convergence of endosomal and autophagy pathways. J Virol 90:8673-8685. https://doi.org/10.1128/jvi.00915-16
  18. Schippers T, Jarosinski K, Osterrieder N. 2015. The ORF012 gene of Marek’s disease virus type 1 produces a spliced transcript and encodes a novel nuclear phosphoprotein essential for virus growth. J Virol 89:1348-1363. https://doi.org/10.1128/jvi.02687-14
  19. *Jarosinski KW, Vautherot JF. 2015. Differential expression of Marek’s disease virus (MDV) late proteins during in vitro and in situ replication: role for pUL47 in regulation of the MDV UL46-UL49 gene locus. Virology 484:213-226. https://doi.org/10.1016/j.virol.2015.06.012
  20. *Jarosinski KW, Donovan KM, Du G. 2015. Expression of fluorescent proteins within the repeat long region of the Marek’s disease virus genome allows direct identification of infected cells while retaining full pathogenicity. Virus Res 201:50-60. https://doi.org/10.1016/j.virusres.2015.02.012
  21. *Veiga IB, Jarosinski KW, Kaufer BB, Osterrieder N. 2013. Marek’s disease virus (MDV) ubiquitin-specific protease (USP) performs critical functions beyond its enzymatic activity during virus replication. Virology 437:110-117. https://doi.org/10.1016/j.virol.2013.01.003
  22. Shaikh SA, Katneni UK, Dong H, Gaddamanugu S, Tavlarides-Hontz P, Jarosinski KW, Osterrieder N, Parcells MS. 2013. A deletion in the glycoprotein L (gL) gene of U.S. Marek’s disease virus (MDV) field strains is insufficient to confer increased pathogenicity to the bacterial artificial chromosome (BAC)-based strain, RB-1B. Avian Dis 57:509-518. https://doi.org/10.1637/10450-112012-reg.1
  23. Schat KA, Piepenbrink MS, Buckles EL, Schukken YH, Jarosinski KW. 2013. Importance of differential expression of Marek’s disease virus gene pp38 for the pathogenesis of Marek’s disease. Avian Dis 57:503-508. https://doi.org/10.1637/10414-100612-Reg.1
  24. *Jarosinski KW, Osterrieder N. 2012. Marek’s disease virus expresses multiple UL44 (gC) variants through mRNA splicing that are all required for efficient horizontal transmission. J Virol 86:7896-7906. https://doi.org/10.1128/jvi.00908-12
  25. *Jarosinski KW, Arndt S, Kaufer BB, Osterrieder N. 2012. Fluorescently tagged pUL47 of Marek’s disease virus reveals differential tissue expression of the tegument protein in vivo. J Virol 86:2428-2436. https://doi.org/10.1128/jvi.06719-11
  26. *Jarosinski KW. 2012. Marek’s disease virus late protein expression in feather follicle epithelial cells as early as 8 days postinfection. Avian Dis 56:725-731. https://doi.org/10.1637/10252-052212-reg.1
  27. *Jarosinski KW. 2012. Dual infection and superinfection inhibition of epithelial skin cells by two alphaherpesviruses co-occur in the natural host. PLoS One 7:e37428. https://doi.org/10.1371/journal.pone.0037428
  28. Kaufer BB, Jarosinski KW, Osterrieder N. 2011. Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation. J Exp Med 208:605-615. https://doi.org/10.1084/jem.20101402
  29. *Kaufer BB, Arndt S, Trapp S, Osterrieder N, Jarosinski KW. Herpesvirus telomerase RNA (vTR) with a mutated template sequence abrogates herpesvirus-induced lymphomagenesis. PLoS Pathog 7:e1002333. https://doi.org/10.1371/journal.ppat.1002333
  30. Kaufer BB, Trapp S, Jarosinski KW, Osterrieder N. 2010. Herpesvirus telomerase RNA(vTR)-dependent lymphoma formation does not require interaction of vTR with telomerase reverse transcriptase (TERT). PLoS Pathog 6:e1001073. https://doi.org/10.1371/journal.ppat.1001073
  31. *Jarosinski KW, Osterrieder N. 2010. Further analysis of Marek’s disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential. J Virol 84:7911-7916. https://doi.org/10.1128/jvi.00433-10
  32. *Jarosinski KW, Hunt HD, Osterrieder N. 2010. Down-regulation of MHC class I by the Marek’s disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion. Virology 405:457-463. https://doi.org/10.1016/j.virol.2010.06.041
  33. Chbab N, Egerer A, Veiga I, Jarosinski KW, Osterrieder N. 2010. Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek’s disease virus (MDV). Vet Res 41:56. https://doi.org/10.1051/vetres/2010026
  34. Fulton A, Peters ST, Perkins GA, Jarosinski KW, Damiani A, Brosnahan M, Buckles EL, Osterrieder N, Van de Walle GR. 2009. Effective treatment of respiratory alphaherpesvirus infection using RNA interference. PLoS One 4:e4118. https://doi.org/10.1371/journal.pone.0004118
  35. Buscaglia C, O’Connell PH, Jarosinski KW, Pevzner I, Schat KA. 2009. Selection for increased nitric oxide production does not increase resistance to Marek’s disease in a primary broiler breeder line. Avian Dis 53:336-340. https://doi.org/10.1637/8536-113008-reg.1
  36. Van de Walle GR, Jarosinski KW, Osterrieder N. Alphaherpesviruses and chemokines: pas de deux not yet brought to perfection. J Virol 82:6090-6097. https://doi.org/10.1128/jvi.00098-08
  37. Miller MM, Jarosinski KW, Schat KA. 2008. Negative modulation of the chicken infectious anemia virus promoter by COUP-TF1 and an E box-like element at the transcription start site binding deltaEF1. J Gen Virol 89:2998-3003. https://doi.org/10.1099/vir.0.2008/003103-0
  38. *Jarosinski KW, Schat KA. 2007. Multiple alternative splicing to exons II and III of viral interleukin-8 (vIL-8) in the Marek’s disease virus genome: the importance of vIL-8 exon I. Virus Genes 34:9-22. https://doi.org/10.1007/s11262-006-0004-9
  39. *Jarosinski KW, Margulis NG, Kamil JP, Spatz SJ, Nair VK, Osterrieder N. 2007. Horizontal transmission of Marek’s disease virus requires US2, the UL13 protein kinase, and gC. J Virol 81:10575-10587. https://doi.org/10.1128/jvi.01065-07
  40. Jarosinski K, Kattenhorn L, Kaufer B, Ploegh H, Osterrieder N. 2007. A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation. Proc Natl Acad Sci USA 104:20025-20030. https://doi.org/10.1073/pnas.0706295104
  41. *Jarosinski KW, Tischer BK, Trapp S, Osterrieder N. Marek’s disease virus: lytic replication, oncogenesis and control. Expert Rev Vaccines 5:761-772. https://doi.org/10.1586/14760584.5.6.761
  42. Poonia B, Dunn PA, Lu H, Jarosinski KW, Schat KA. 2006. Isolation and molecular characterization of a new Muscovy duck parvovirus from Muscovy ducks in the USA. Avian Pathol 35:435-441. https://doi.org/10.1080/03079450601009563
  43. Li X, Jarosinski KW, Schat KA. Expression of Marek’s disease virus phosphorylated polypeptide pp38 produces splice variants and enhances metabolic activity. Vet Microbiol 117:154-168. https://doi.org/10.1016/j.vetmic.2006.06.019
  44. Miller MM, Jarosinski KW, Schat KA. 2005. Positive and negative regulation of chicken anemia virus transcription. J Virol 79:2859-2868 https://doi.org/10.1128/jvi.79.5.2859-2868.2005
  45. Jarosinski KW, Osterrieder N, Nair VK, Schat KA. 2005. Attenuation of Marek’s disease virus by deletion of open reading frame RLORF4 but not RLORF5a. J Virol 79:11647-11659. https://doi.org/10.1128/jvi.79.18.11647-11659.2005
  46. Jarosinski KW, Njaa BL, O’Connell P H, Schat KA. 2005. Pro-inflammatory responses in chicken spleen and brain tissues after infection with very virulent plus Marek’s disease virus. Viral Immunol 18:148-161 https://doi.org/10.1089/vim.2005.18.148
  47. Yunis R, Jarosinski KW, Schat KA. 2004. Association between rate of viral genome replication and virulence of Marek’s disease herpesvirus strains. Virology 328:142-150. https://doi.org/10.1637/0005-2086(2002)046[0636:iogrot]2.0.co;2
  48. *Jarosinski KW, O’Connell PH, Schat KA. 2003. Impact of deletions within the Bam HI-L fragment of attenuated Marek’s disease virus on vIL-8 expression and the newly identified transcript of open reading frame LORF4. Virus Genes 26:255-269. https://doi.org/10.1023/a:1024447230464
  49. Jarosinski KW, Yunis R, O’Connell PH, Markowski-Grimsrud CJ, Schat KA. Influence of genetic resistance of the chicken and virulence of Marek’s disease virus (MDV) on nitric oxide responses after MDV infection. Avian Dis 46:636-649. https://doi.org/10.1637/0005-2086(2002)046[0636:iogrot]2.0.co;2 (P.P. Levine Award for best paper published in Avian Diseases in 2002)
  50. Jarosinski KW, Massa PT. 2002. Interferon regulatory factor-1 is required for interferon-gamma-induced MHC class I genes in astrocytes. J Neuroimmunol 122:74-84. https://doi.org/10.1016/s0165-5728(01)00467-2
  51. Jarosinski KW, Whitney LW, Massa PT. 2001. Specific deficiency in nuclear factor-kappaB activation in neurons of the central nervous system. Lab Invest 81:1275-1288. https://doi.org/10.1038/labinvest.3780341
  52. Jarosinski KW, Jia W, Sekellick MJ, Marcus PI, Schat KA. 2001. Cellular responses in chickens treated with IFN-alpha orally or inoculated with recombinant Marek’s disease virus expressing IFN-alpha. J Interferon Cytokine Res 21:287-296. https://doi.org/10.1089/107999001300177475
  53. Massa PT, Saha S, Wu C, Jarosinski KW. 2000. Expression and function of the protein tyrosine phosphatase SHP-1 in oligodendrocytes. Glia 29:376-385. https://doi.org/10.1002/(SICI)1098-1136(20000215)29:4%3C376::AID-GLIA8%3E3.0.CO;2-S
  54. Massa PT, Whitney LW, Wu C, Ropka SL, Jarosinski KW. 1999. A mechanism for selective induction of 2′-5′ oligoadenylate synthetase, anti-viral state, but not MHC class I genes by interferon-beta in neurons. J Neurovirol 5:161-171. https://doi.org/10.3109/13550289909021998

*indicates corresponding author

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