NEWS AND EVENTS
Makoto won Zoetis Award!
Makoto received Zoetis Award for Research Excellence for the University of Illinois College of Veterinary Medicine. Congratulations Makoto!
Honorable mention poster
Rachel participated in the Vet Med’s annual Celebration of Research with her poster on the topic of “Impact of Early Like Trauma on Autoimmune Disease Phenotype and Development via Dysregulated β1 Adrenergic Signaling”. Her poster won honorable mention with the prize of $500 for research use. Congratulations Rachell!
Rachel won the C. Ladd Prosser award!
Inoue lab’s fourth year neuroscience graduate student won the 2021 C. Ladd Prosser award which recognizes the research contribution of a Graduate Student that stands out as THE BEST SCIENTIFIC ACHIEVEMENT with THE BROADEST SIGNIFICANCE for the discipline of neuroscience.
Congratulations Rachel!
Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by a high degree of neuronal damage, T cell infiltration, and reactive gliosis in spinal cord gray matter. Using conditional knockout mice, we show that T cell migration to spinal cord gray matter depends on T cell expression of CXCR2 and astrocyte expression of TAK1-mediated chemokines such as CXCL1.
Read more: https://www.pnas.org/content/118/8/e2017213118.short
Lab publication
Our paper “Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis” was published in PNAS.
Read more at DOI: https://doi.org/10.1073/pnas.2017213118
Our work is featured in UIUC News Bereau
Our recently published work on the impact of early life trauma on an animal model of multiple sclerosis is featured in the news by UIUC News Bereau.
Read news story: https://news.illinois.edu/view/6367/530521238
Read published article: https://www.nature.com/articles/s41467-020-20302-0
Rachel passed her preliminary exam!
Rachel (Yee Ming) passed her preliminary exam on the 6th of January, 2021 and is now a PhD candidate. Congratulations Rachel!
Immune regulation of CNS dysfunction in Cryptococcus-associated Immune Reconstitution Inflammatory Syndrome (C-IRIS)
Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes similar to human C-IRIS symptoms, such as systemic upregulation of some inflammatory cytokines and brain edema.
Read more: https://www.frontiersin.org/articles/10.3389/fimmu.2020.529219/full
Lab publication
Our paper “Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling” was published in Nature Communications, 12(1), 105, in January 2021.
Read more: https://www.nature.com/articles/s41467-020-20302-0
Lab publication
Our paper “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficient in an animal model of multiple sclerosis” was published in Biomaterials Science.
This work was featured on the cover of Biomaterials Science, Volume 8, Number 19, October 2020.
Read more: https://pubs.rsc.org/en/content/articlelanding/2020/BM/D0BM00957A#!divAbstract
Makoto won Zoetis Award!
Makoto received Zoetis Award for Research Excellence for the University of Illinois College of Veterinary Medicine. Congratulations Makoto!
Honorable mention poster
Rachel participated in the Vet Med’s annual Celebration of Research with her poster on the topic of “Impact of Early Like Trauma on Autoimmune Disease Phenotype and Development via Dysregulated β1 Adrenergic Signaling”. Her poster won honorable mention with the prize of $500 for research use. Congratulations Rachell!
Rachel won the C. Ladd Prosser award!
Inoue lab’s fourth year neuroscience graduate student won the 2021 C. Ladd Prosser award which recognizes the research contribution of a Graduate Student that stands out as THE BEST SCIENTIFIC ACHIEVEMENT with THE BROADEST SIGNIFICANCE for the discipline of neuroscience.
Congratulations Rachel!
Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and neuronal damage. While T cells are consistently detected in the gray matter of human MS samples, they are rarely seen in the gray matter of the most common mouse model of MS. Here, we show a modified mouse model that is characterized by a high degree of neuronal damage, T cell infiltration, and reactive gliosis in spinal cord gray matter. Using conditional knockout mice, we show that T cell migration to spinal cord gray matter depends on T cell expression of CXCR2 and astrocyte expression of TAK1-mediated chemokines such as CXCL1.
Read more: https://www.pnas.org/content/118/8/e2017213118.short
Lab publication
Our paper “Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis” was published in PNAS.
Read more at DOI: https://doi.org/10.1073/pnas.2017213118
Our work is featured in UIUC News Bereau
Our recently published work on the impact of early life trauma on an animal model of multiple sclerosis is featured in the news by UIUC News Bereau.
Read news story: https://news.illinois.edu/view/6367/530521238
Read published article: https://www.nature.com/articles/s41467-020-20302-0
Rachel passed her preliminary exam!
Rachel (Yee Ming) passed her preliminary exam on the 6th of January, 2021 and is now a PhD candidate. Congratulations Rachel!
Immune regulation of CNS dysfunction in Cryptococcus-associated Immune Reconstitution Inflammatory Syndrome (C-IRIS)
Immune reconstitution inflammatory syndrome (IRIS) is a pathological condition whereby a recovering immune system paradoxically worsens the patient’s condition by responding excessively to a previously acquired infection. IRIS has been reported in patients, who are recovering from an immunocompromised condition and pre-infected with fungi such as Cryptococcus (C-IRIS). We reported a mouse model that presents phenotypes similar to human C-IRIS symptoms, such as systemic upregulation of some inflammatory cytokines and brain edema.
Read more: https://www.frontiersin.org/articles/10.3389/fimmu.2020.529219/full
Lab publication
Our paper “Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling” was published in Nature Communications, 12(1), 105, in January 2021.
Read more: https://www.nature.com/articles/s41467-020-20302-0
Lab publication
Our paper “Induction of a higher-ordered architecture in glatiramer acetate improves its biological efficient in an animal model of multiple sclerosis” was published in Biomaterials Science.
This work was featured on the cover of Biomaterials Science, Volume 8, Number 19, October 2020.
Read more: https://pubs.rsc.org/en/content/articlelanding/2020/BM/D0BM00957A#!divAbstract