About Noelle James

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So far Noelle James has created 2 blog entries.

Erin O’Leary publishes

Congratulations to Erin O’Leary on her 1st author publication covering her work as a technician in Dr. Gökhan Mutlu’s lab at the University of Chicago.

This work built on their previous findings that glycine is required for collagen synthesis in myofibroblasts. This paper sought to determine the role of ATF4 in this pathway. AFT4 is a regulator of amino acid metabolism. They found that primary driver of ATF4 downstream of TGF-β is activation of the Mechanistic Target of Rapamycin Complex 1 (mTORC1). They used a panel of mTOR inhibitors and found that Rapalink-1, which specifically targets the kinase domain of mTORC1, completely inhibited ATF4 induction and metabolic reprogramming downstream of TGF-β.

 

Publication

O’Leary, E. M., Tian, Y., Nigdelioglu, R., Witt, L. J., Cetin-Atalay, R., Meliton, A. Y., Woods, P. S., Kimmig, L. M., Sun, K. A., Gökalp, G. A., Mutlu, G. M., & Hamanaka, R. B. (2020). TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation. American Journal of Respiratory Cell and Molecular Biology.
DOI: 10.1165/rcmb.2020-0143OC, PMID: 32668192

Erin O’Leary publishes2020-08-25T15:28:26-05:00

Preprint: Dopa decarboxylase is a genetic hub of parental control over offspring behavior

Dopa decarboxylase (Ddc) is a genetic hub of parental control over offspring behavior

Hop on over to bioRxiv to see Dr. Bonthuis’ latest paper on how Ddc, a monoaminergic regulator, is influenced by parentage and in turn effects social behavior. He found maternal and paternal Ddc alleles control distinct behavioral sequences. Additionally, Ddc exhibits dominant expression of the maternal allele in subpopulations of cells in 14 of 52 brain regions.

Preprint: Dopa decarboxylase is a genetic hub of parental control over offspring behavior2022-03-10T15:18:45-06:00
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