Selected manuscripts (2019)

The epigenetic impacts of endocrine disruptors on female reproduction across generations†. Rattan S, Flaws JA. Biol Reprod. 2019 May 11. pii: ioz081. doi: 10.1093/biolre/ioz081.

Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis. Damdimopoulou P, Chiang C, Flaws JA. Reprod Toxicol. 2019 May 3;87:32-41. doi: 10.1016/j.reprotox.2019.04.007.

Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice. Hatcher KM, Willing J, Chiang C, Rattan S, Flaws JA, Mahoney MM. Physiol Behav. 2019 Apr 22;207:7-14. doi:  0.1016/j.physbeh.2019.04.018.

Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction. Brehm E, Flaws JA. Endocrinology. 2019 Jun 1;160(6):1421-1435. doi: 10.1210/en.2019-00034.

Response to the Comments of Delclos et al. Flaws JA, Warner GR. Toxicol Sci. 2019 May 1;169(1):3-4. doi: 10.1093/toxsci/kfz073. No abstract available.

Chronic Exposure of Mice to Bisphenol-A Alters Uterine FGF Signaling and Leads to Aberrant Epithelial Proliferation. Neff AM, Blanco SC, Flaws JA, Bagchi IC, Bagchi MK. Endocrinology. 2019 Mar 20. pii: en.2018-00872. doi: 10.1210/en.2018-00872.

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling. Madak-Erdogan Z, Band S, Zhao YC, Smith BP, Kulkoyluoglu-Cotul E, Zuo Q, Santaliz Casiano A, Wrobel K, Rossi G, Smith RL, Kim SH, Katzenellenbogen JA, Johnson ML, Patel M, Marino N, Storniolo AMV, Flaws JA. Cancer Res. 2019 May 15;79(10):2494-2510. doi: 10.1158/0008-5472.CAN-18-2849. Epub 2019 Mar 12.

Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture. Warner GR, Li Z, Houde ML, Atkinson CE, Meling DD, Chiang C, Flaws JA. Toxicol Sci. 2019 May 1;169(1):246-259. doi: 10.1093/toxsci/kfz047.

Subchronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice. Chiang C, Flaws JA. Toxicol Sci. 2019 Apr 1;168(2):620-631. doi: 10.1093/toxsci/kfz013.

Hormone variability and hot flash experience: Results from the midlife women’s health study. Chiang C, Gallicchio L, Zacur H, Miller S, Flaws JA, Smith RL. Maturitas. 2019 Jan;119:1-7. doi: 10.1016/j.maturitas.2018.10.007. Epub 2018 Oct 23.

Selected manuscripts (2018)

Smith RL, Gallicchio LM, Flaws JA. Understanding the complex relationships underlying hot flashes: a Bayesian network approach. Menopause 2018; 25:182-190.

Brehm E, Rattan S, Gao L, Flaws JA. Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 2018; 159:795-809.

Rattan S, Brehm E, Gao L, Niermann S, Flaws JA. Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice. Biol Reprod 2018; 98:130-145.

Rattan S, Brehm E, Gao L, Flaws JA. Di(2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice. Toxicol Sci 2018.

Kundu P, Patel S, Meling DD, Deal K, Gao L, Helferich WG, Flaws JA. The effects of dietary levels of genistein on ovarian follicle number and gene expression. Reprod Toxicol 2018; 81:132-139.

Richardson KA, Hannon PR, Johnson-Walker YJ, Myint MS, Flaws JA, Nowak RA. Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice. Reprod Toxicol 2018; 77:70-79.

Eckstrum KS, Edwards W, Banerjee A, Wang W, Flaws JA, Katzenellenbogen JA, Kim SH, Raetzman LT. Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development. Endocrinology 2018; 159:119-131.

Li Q, Lawrence CR, Nowak RA, Flaws JA, Bagchi MK, Bagchi IC. Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. Endocrinology 2018; 159:2216-2228.

Selected manuscripts (2016-2017)

Berger, A., Ziv-Gal A., Cudiamat, J., Wang, W., Zhou, C., Flaws, J.A.  (2016) The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.  Reproductive Toxicology 60:39-52.

Gallicchio L., Miller S.R., Kiefer J., Greene T., Zacur H.A., Flaws, J.A. (2016) The associations between body mass index, smoking, and alcohol intake with ovarian volume in midlife women.  Journal of Women’s Health 25:409-15.

Hannon, P., Niermann, S., Flaws, J.A. (2016) Acute exposure to di(2-ethylhexyl) phthalate in adulthood causes adverse reproductive outcomes later in life and accelerates reproductive aging in female mice.  Toxicological Sciences 150:97-108.

Patel, S., Peretz, J., Pan, X-Y, Helferich, W.G., Flaws, J.A.  (2016)  Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.  Toxicology Applied Pharmacology 293:53-62.

Ziv-Gal, A., Gallicchio, L., Chiang, C., Ther, S.N., Miller, S.R., Zacur, H.A., Dills, R.L., Flaws, J.A. (2016)  Phthalate metabolite levels and menopausal hot flashes in midlife women.  Reproductive Toxicology 60:76-81.

Mahalingam, S., Gao, G., Gonnering, M., Flaws, J.A.  (2016) Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles.  Toxicology Applied Pharmacology 295:47-55.

Li, Q., Davila, J., Kannan, A., Flaws, J.A., Bagchi, M.K., Bagchi, I. C. (2016) Chronic exposures to low levels of BPA affect uterine function during early pregnancy.  Endocrinology 157:1764-74.

Gallicchio, L., Flaws, J.A., Smith, R.L.  (2016)  Age at menarche, androgen concentrations, and midlife obesity: Findings from the Midlife Women’s Health Study.  Menopause 23:1182-1188.

Smith, R.L., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A.  (2016) Risk factors for extended duration and timing of peak severity of hot flashes.  PlosOne 11:e0155079.

Jeong, C., Gao, L., Dettro, T., Wagner, E.D., Ricke, W.A., Plewa, M.J., Flaws, J.A.  (2016) Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro.  Reproductive Toxicology 62:71-76.

Ziv-Gal A., Flaws, J.A.  (2016) Evidence for bisphenol A-induced female infertility-review (2007-2016).  Fertility and Sterility 15: 827-56.

Gong, P., Madak-Erdogan, Z., Katzenellenbogen, J., Flaws, J.A., Shapiro, D.J., Katzenellenbogen, B.S. (2016) Estrogen receptor-a and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells. Molecular Cellular Endocrinology 437:190-200.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2016) Factors affecting sexual function in mid-life women: results from the midlife health study. Journal of Women’s Health (in press).

Mahalingam, S., Gao, L., Eisner, J., Helferich, W., Flaws, J.A.  (2016) Effects of isoliquirtigenin on ovarian antral follicle growth and steroidogenesis.  Reproductive Toxicology 66:107-114.

Zhou, C., Flaws, J.A.  (2017) Effects of an environmentally relevant phthalate mixture on cultured mouse antral follicles.  Toxicological Sciences (in press).

Barakat, R., Lin, P-C., Rattan, S., Brehm, E.S., Canisso, I.F., Abosalum, M.E., Flaws, J.A., Hess, R., Ko, C.  (2017) Prenatal exposure to DEHP induces premature reproductive senescence in male mice.  Toxicological Sciences (in press).

Zhou, C., Gao, L., Flaws, J.A.  (2017) Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice.  Toxicology Applied Pharmacology 318:49-57.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2017) Factors affecting sexual function in mid-life women: Results from the Midlife Women’s Health Study.  Journal of Women’s Health (in press).

Chiang, C., Mahalingam, S., Flaws, J.A.  (2017)  Environmental contaminants affecting fertility and somatic health.  Seminars in Reproductive Medicine (in press).


Complete list of published work in my bibliography