Selected manuscripts (2023)

Hatcher, K.M., Smith, R.L., Chiang, C., Flaws, J.A., Mahoney, M.M. Self-reported depressive symptoms and hot flashes, but not serum hormone concentrations are predictors on self-reported sleep disruptions in menopausal women: Results from the Midlife Women’s Health Study. Journal of Women’s Health. 2023 Jan;32(1):94-101.

Furth, P.A., Wang, W., Kang, K., Rooney, B.L., Keegan, G, Muralidaran, V., Zou, X., Flaws, J.A. Esr1, but not Cyp19a1 over-expression in mammary epithelial cells during reproductive senescence induces proliferative mammary disease reminiscent of pregnancy that is responsive to anti-hormonals. American Journal of Pathology. 2023 Jan;193(1):84-102.

Furth, P.A., Wang, W., Kang, K., Rooney, B.L., Keegan, G., Muralidaran, V., Zou, X., Flaws, J.A. (2023) Increased prevalence of ER+ mammary adenocarcinoma correlated with a risk signature found in aging Esr1, but not CYP19A1 over-expressing mice. American Journal of Pathology (in press).

Babadi, R.S., Williams, P.L., Li., Z., Smith, R.L., Strakovsky, R.S., Hauser, R., Flaws, J.A., James-Todd, T. Urinary phthalate metabolite concentration and hot flash outcomes: longitudinal associations in the Midlife Women’s Health Study. Environmental Research. 2023 Jan 1;216(Pt 2):114576.

Selected manuscripts (2022)

Ge, X., Weis, K., Flaws, J.A., Raetzman, L. Prenatal exposure to the endocrine disrupting chemical DEHP impacts reproduction-related gene expression in the pituitary. Reproductive Toxicology 2022 108:18-27.

Yang, M., Lee, Y., Gao, L., Chiu, K., Meling, D.D., Flaws, J.A., Warner, G.R. Perfluorooctanoic acid (PFOA) disrupts ovarian steroidogenesis and folliculogenesis in adult mice. 2022 Toxicological Sciences 186:260-268.

Pacyga, D.G., Ryva, B.A., Nowak, R. Bulun, S.E., Yin, P., Li, Z., Flaws, J.A., Strakovsky, R.S. Midlife urinary phthalate metabolite concentrations and prior uterine fibroid diagnosis. International Journal of Environmental Research and Public Health 2022 19:2741.

Fletcher, E., Santacruz, R., Mourikes, V., Neff, A., Flaws, J.A. Effects of phthalate mixtures on the ovary and female reproduction. 2022 Toxics 10:251.

Gonsioroski, A., Aquino, A.M., Alonso-Costa, L.G., Barbisan, L.F., Scarano, W.R., Flaws, J.A. Multigenerational effects of an environmentally relevant phthalate mixture on reproductive parameters and ovarian miRNA expression in female rats. Toxicological Sciences 2022 189:91-106.

Stewart, J.L., Gao, L., Flaws, J.A., Mercadante, V.R.G., Dias, N.W., Canisso, I.F., Lima, F.S. Effects of nerve growth factor-b from bull seminal plasma on steroidogenesis and angiogenic markers of the bovine pre-ovulatory follicle wall cell culture. Frontiers in Veterinary Science January 17,2022.

Kloboves, M.E., Pacyga, D.C., Gardiner, J.C., Flaws, J.A., Schantz, S.L., Strakovsky, R.S. Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio. Human Reproduction 2022 37:2154-2166.

Cavalca, A.M.B., Mosele, F.C., Aquino, A.M., Justulin, L.Delella, F.K., Flaws, J.A., Scarano, W.R. Effects of a phthalate metabolite mixture on both normal and tumoral human prostate cells. Environmental Toxicology 2022 37:2566-2578.

Ryva, B.A., Haggerty, D.K., Pacyga, D.C., James-Todd, T., Flaws, J.A., Li, Z., Strakovsky, R.S. Determinants of urinary phthalate biomarker concentrations in pre- and perimenopausal women with consideration of race. Environmental Research 2022 214(Pt 3):114056.

Iizuka, T., Yin, P., Zuberi, A., Kujawa, S.A., Coon, J.S., Björvang, R., Damdimopoulou, P., Pacyga, D.C., Strakovsky, R.S., Flaws, J.A., Bulun, S.E. Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation. PNAS 2022 Nov 22;119(47)e2208886119.

Bashir, S.T., Chiu, K., Zheng, E., Martinez, A., Chiu, J., Raj, K., Stasiak, S., Lai, N., Arcanjo, R.B., Flaws, J.A., Nowak, R.A. Subchronic exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate differentially affects the colon and ileum in adult female mice. Chemosphere 2022 Dec;309(Pt 1):136680.

Shree, N. Ding, Z., Flaws, J.A., Choudhury, M. Role of microRNA in endocrine disruptor-induced immunomodulation of metabolic health. Metabolites. 2022 Oct 28;12(11):1034.

Gonsioroski AV, Aquino AM, Alonso-Costa LG, Barbisan LF, Scarano WR, Flaws JA. Multigenerational effects of an environmentally relevant phthalate mixture on reproductive parameters and ovarian miRNA expression in female rats. Toxicol Sci. 2022 Jun 28:kfac066. doi: 10.1093/toxsci/kfac066. Online ahead of print. PMID: 35762964

Gonsioroski A, Laws M, Mourikes VE, Neff A, Drnevich J, Plewa MJ, Flaws JA. Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles. J Environ Sci (China). 2022 Jul;117:46-57. doi: 10.1016/j.jes.2022.01.018. Epub 2022 Jan 24. PMID: 35725088

Gonsioroski A, Plewa MJ, Flaws JA. Effects of prenatal and Lactational exposure to Iodoacetic acid on the F1 generation of mice. Biol Reprod. 2022 Apr 26:ioac079. doi: 10.1093/biolre/ioac079. Online ahead of print. PMID: 35470848

Meling DD, De La Torre KM, Arango AS, Gonsioroski A, Deviney ARK, Neff AM, Laws MJ, Warner GR, Tajkhorshid E, Flaws JA. Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary. Reprod Toxicol. 2022 Jun;110:113-123. doi: 10.1016/j.reprotox.2022.04.002. Epub 2022 Apr 11. PMID: 35421560

Chiu KK, Bashir ST, Abdel-Hamid AM, Clark LV, Laws MJ, Cann I, Nowak RA, Flaws JA. Isolation of DiNP-Degrading Microbes from the Mouse Colon and the Influence DiNP Exposure Has on the Microbiota, Intestinal Integrity, and Immune Status of the Colon. Toxics. 2022 Feb 6;10(2):75. doi: 10.3390/toxics10020075. PMID: 35202261

Neff AM, Laws MJ, Warner GR, Flaws JA. The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition. Curr Environ Health Rep. 2022 Mar;9(1):53-79. doi: 10.1007/s40572-022-00334-y. Epub 2022 Feb 1. PMID: 35103957

Selected manuscripts (2021)

Blake C, Flaws JA. Using semantics to scale up evidence-based chemical risk-assessments. PLoS One. 2021 Dec 15;16(12):e0260712. doi: 10.1371/journal.pone.0260712. eCollection 2021. PMID: 34910747

Brehm E, Flaws JA. Prenatal exposure to a mixture of phthalates accelerates the age-related decline in reproductive capacity but may not affect direct biomarkers of ovarian aging in the F1 generation of female mice. Environ Epigenet. 2021 Oct 25;7(1):dvab010. doi: 10.1093/eep/dvab010. eCollection 2021. PMID: 34707890

Gill S, Brehm E, Leon K, Chiu J, Meling DD, Flaws JA. Prenatal exposure to an environmentally relevant phthalate mixture alters ovarian steroidogenesis and folliculogenesis in the F1 generation of adult female mice. Reprod Toxicol. 2021 Dec;106:25-31. doi: 10.1016/j.reprotox.2021.09.013. Epub 2021 Sep 28. PMID: 34597818

Chiu K, Bashir ST, Gao L, Gutierrez J, de Godoy MRC, Drnevich J, Fields CJ, Cann I, Flaws JA, Nowak RA. Subacute Exposure to an Environmentally Relevant Dose of Di-(2-ethylhexyl) Phthalate during Gestation Alters the Cecal Microbiome, but Not Pregnancy Outcomes in Mice. Toxics. 2021 Sep 9;9(9):215. doi: 10.3390/toxics9090215. PMID: 34564366

Chiu K, Bashir ST, Chiu J, Nowak RA, Flaws JA. The Impact of Di-Isononyl Phthalate Exposure on Specialized Epithelial Cells in the Colon. Toxicol Sci. 2021 Oct 27;184(1):142-153. doi: 10.1093/toxsci/kfab105. PMID: 34453847

Laws MJ, Neff AM, Brehm E, Warner GR, Flaws JA. Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models. Adv Pharmacol. 2021;92:151-190. doi: 10.1016/bs.apha.2021.03.008. Epub 2021 May 3. PMID: 34452686

Gonsioroski A, Meling DD, Gao L, Plewa MJ, Flaws JA. Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice. Biol Reprod. 2021 Oct 11;105(4):1030-1042. doi: 10.1093/biolre/ioab108. PMID: 34086879

Chiang C, Pacyga DC, Strakovsky RS, Smith RL, James-Todd T, Williams PL, Hauser R, Meling DD, Li Z, Flaws JA. Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women’s Health Study. Environ Int. 2021 May 15;156:106633. doi: 10.1016/j.envint.2021.106633. Review.

Neff AM, Flaws JA. The effects of plasticizers on the ovary. Curr Opin Endocr Metab Res. 2021 Jun;18:35-47. doi: 10.1016/j.coemr.2021.01.004. Epub 2021 Feb 10. PMID: 33997465

Warner GR, Pacyga DC, Strakovsky RS, Smith R, James-Todd T, Williams PL, Hauser R, Meling DD, Li Z, Flaws JA. Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women. Environ Res. 2021 Mar 17;197:110891. doi: 10.1016/j.envres.2021.110891. Online ahead of print. PMID: 33722529

Mourikes VE, Flaws JA. Effects of Chemical Mixtures on the Ovary. Reproduction. 2021 Feb 1:REP-20-0587.R1. doi: 10.1530/REP-20-0587. Online ahead of print. PMID: 33528380 Review.

Warner GR, Meling DD, De La Torre KM, Wang K, Flaws JA. Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries. Biol Reprod. 2021 Apr 1;104(4):806-817. doi: 10.1093/biolre/ioab010. PMID: 33511402

Selected manuscripts (2020)

Meling DD, Warner GR, Szumski JR, Gao L, Gonsioroski AV, Rattan S, Flaws JA. The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice. Toxicol Appl Pharmacol. 2020 Feb 1;388:114875. doi: 10.1016/j.taap.2019.114875.

Warner GR, Mourikes VE, Neff AM, Brehm E, Flaws JA. Mechanisms of action of agrochemicals acting as endocrine disrupting chemicals. Mol Cell Endocrinol. 2020 Feb 15;502:110680. doi: 10.1016/j.mce.2019.110680.

Chiang C, Lewis LR, Borkowski G, Flaws JA. Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice. Reprod Toxicol. 2020 Apr;93:28-42. doi: 10.1016/j.reprotox.2019.12.006.

Chiang C, Lewis LR, Borkowski G, Flaws JA. Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse. Toxicol Appl Pharmacol. 2020 Apr 15;393:114952. doi: 10.1016/j.taap.2020.114952.

Gonsioroski A, Mourikes VE, Flaws JA. Endocrine Disruptors in Water and Their Effects on the Reproductive System. Int J Mol Sci. 2020 Mar 12;21(6). pii: E1929. doi: 10.3390/ijms21061929. Review.

Chiu K, Bashir ST, Nowak RA, Mei W, Flaws JA. Subacute exposure to di-isononyl phthalate alters the morphology, endocrine function, and immune system in the colon of adult female mice. Sci Rep. 2020 Nov 2;10(1):18788. doi: 10.1038/s41598-020-75882-0. PMID: 33139756

Brehm E, Zhou C, Gao L, Flaws JA. Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. Reprod Toxicol. 2020 Dec;98:260-268. doi: 10.1016/j.reprotox.2020.10.009. Epub 2020 Oct 28. PMID: 33129917

Selected manuscripts (2019)

Chiang, C., Flaws, J.A. Acute exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood has immediate and long-term reproductive consequences in female mice. Toxicological Sciences 2019; 168:620-631.

Rattan, S., Beers, H.K., Kannan, A., Ramakrishnan, A., Brehm, E., Bagchi, I., Irudayaraj, J.M.K., Flaws, J.A. Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries. Toxicology and Applied Pharmacology 2019; 379:114629.

Warner, G., Flaws, J.A. Commentary, Gestational diabetes and fetal programming: A mechanism for the influence of the prenatal environment on adult fertility. Endocrinology 2019; 160:2469-2470.

Gonsioroski A., Meling, D.D., Gao, L., Plewa, M.J., Flaws, J.A. Iodoacetic acid inhibits follicle growth and alters expression of genes that regulate apoptosis, the cell cycle, estrogen receptors, and ovarian steroidogenesis in mouse ovarian follicles. Reproductive Toxicology 2020 Jan;91:101-108. doi: 10.1016/j.reprotox.2019.10.005. Epub 2019 Nov 3.

Rattan S, Flaws JA. The epigenetic impacts of endocrine disruptors on female reproduction across generations. Biol Reprod. 2019 Sep 1;101(3):635-644. doi: 10.1093/biolre/ioz081.

Damdimopoulou P, Chiang C, Flaws JA. Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis. Reprod Toxicol. 2019 May 3;87:32-41. doi: 10.1016/j.reprotox.2019.04.007.

Hatcher KM, Willing J, Chiang C, Rattan S, Flaws JA, Mahoney MM. Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice. Physiol Behav. 2019 Apr 22;207:7-14. doi:  0.1016/j.physbeh.2019.04.018.

Brehm E, Flaws JA. Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction. Endocrinology. 2019 Jun 1;160(6):1421-1435. doi: 10.1210/en.2019-00034.

Flaws JA, Warner GR. Response to the Comments of Delclos et al. Toxicol Sci. 2019 May 1;169(1):3-4. doi: 10.1093/toxsci/kfz073.

Neff AM, Blanco SC, Flaws JA, Bagchi IC, Bagchi MK. Chronic Exposure of Mice to Bisphenol-A Alters Uterine FGF Signaling and Leads to Aberrant Epithelial Proliferation. Endocrinology. 2019 May 1;160(5):1234-1246. doi: 10.1210/en.2018-00872.

Madak-Erdogan Z, Band S, Zhao YC, Smith BP, Kulkoyluoglu-Cotul E, Zuo Q, Santaliz Casiano A, Wrobel K, Rossi G, Smith RL, Kim SH, Katzenellenbogen JA, Johnson ML, Patel M, Marino N, Storniolo AMV, Flaws JA. Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling. Cancer Res. 2019 May 15;79(10):2494-2510. doi: 10.1158/0008-5472.CAN-18-2849.

Warner GR, Li Z, Houde ML, Atkinson CE, Meling DD, Chiang C, Flaws JA. Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture. Toxicol Sci. 2019 May 1;169(1):246-259. doi: 10.1093/toxsci/kfz047.

Chiang C, Flaws JA. Subchronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice. Toxicol Sci. 2019 Apr 1;168(2):620-631. doi: 10.1093/toxsci/kfz013.

Chiang C, Gallicchio L, Zacur H, Miller S, Flaws JA, Smith RL. Hormone variability and hot flash experience: Results from the midlife women’s health study. Maturitas. 2019 Jan; 119:1-7. doi: 10.1016/j.maturitas.2018.10.007.

Selected manuscripts (2018)

Smith RL, Gallicchio LM, Flaws JA. Understanding the complex relationships underlying hot flashes: a Bayesian network approach. Menopause 2018; 25:182-190.

Brehm E, Rattan S, Gao L, Flaws JA. Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 2018; 159:795-809.

Rattan S, Brehm E, Gao L, Niermann S, Flaws JA. Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice. Biol Reprod 2018; 98:130-145.

Rattan S, Brehm E, Gao L, Flaws JA. Di(2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice. Toxicol Sci 2018; 63(2):420-429.

Kundu P, Patel S, Meling DD, Deal K, Gao L, Helferich WG, Flaws JA. The effects of dietary levels of genistein on ovarian follicle number and gene expression. Reprod Toxicol 2018; 81:132-139.

Richardson KA, Hannon PR, Johnson-Walker YJ, Myint MS, Flaws JA, Nowak RA. Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice. Reprod Toxicol 2018; 77:70-79.

Eckstrum KS, Edwards W, Banerjee A, Wang W, Flaws JA, Katzenellenbogen JA, Kim SH, Raetzman LT. Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development. Endocrinology 2018; 159:119-131.

Li Q, Lawrence CR, Nowak RA, Flaws JA, Bagchi MK, Bagchi IC. Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. Endocrinology 2018; 159:2216-2228.

Selected manuscripts (2016-2017)

Berger, A., Ziv-Gal A., Cudiamat, J., Wang, W., Zhou, C., Flaws, J.A.  (2016) The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.  Reproductive Toxicology 60:39-52.

Gallicchio L., Miller S.R., Kiefer J., Greene T., Zacur H.A., Flaws, J.A. (2016) The associations between body mass index, smoking, and alcohol intake with ovarian volume in midlife women.  Journal of Women’s Health 25:409-15.

Hannon, P., Niermann, S., Flaws, J.A. (2016) Acute exposure to di(2-ethylhexyl) phthalate in adulthood causes adverse reproductive outcomes later in life and accelerates reproductive aging in female mice.  Toxicological Sciences 150:97-108.

Patel, S., Peretz, J., Pan, X-Y, Helferich, W.G., Flaws, J.A.  (2016)  Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.  Toxicology Applied Pharmacology 293:53-62.

Ziv-Gal, A., Gallicchio, L., Chiang, C., Ther, S.N., Miller, S.R., Zacur, H.A., Dills, R.L., Flaws, J.A. (2016)  Phthalate metabolite levels and menopausal hot flashes in midlife women.  Reproductive Toxicology 60:76-81.

Mahalingam, S., Gao, G., Gonnering, M., Flaws, J.A.  (2016) Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles.  Toxicology Applied Pharmacology 295:47-55.

Li, Q., Davila, J., Kannan, A., Flaws, J.A., Bagchi, M.K., Bagchi, I. C. (2016) Chronic exposures to low levels of BPA affect uterine function during early pregnancy.  Endocrinology 157:1764-74.

Gallicchio, L., Flaws, J.A., Smith, R.L.  (2016)  Age at menarche, androgen concentrations, and midlife obesity: Findings from the Midlife Women’s Health Study.  Menopause 23:1182-1188.

Smith, R.L., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A.  (2016) Risk factors for extended duration and timing of peak severity of hot flashes.  PlosOne 11:e0155079.

Jeong, C., Gao, L., Dettro, T., Wagner, E.D., Ricke, W.A., Plewa, M.J., Flaws, J.A.  (2016) Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro.  Reproductive Toxicology 62:71-76.

Ziv-Gal A., Flaws, J.A.  (2016) Evidence for bisphenol A-induced female infertility-review (2007-2016).  Fertility and Sterility 15: 827-56.

Gong, P., Madak-Erdogan, Z., Katzenellenbogen, J., Flaws, J.A., Shapiro, D.J., Katzenellenbogen, B.S. (2016) Estrogen receptor-a and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells. Molecular Cellular Endocrinology 437:190-200.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2016) Factors affecting sexual function in mid-life women: results from the midlife health study. Journal of Women’s Health 26(2):103-108.

Mahalingam, S., Gao, L., Eisner, J., Helferich, W., Flaws, J.A.  (2016) Effects of isoliquirtigenin on ovarian antral follicle growth and steroidogenesis.  Reproductive Toxicology 66:107-114.

Zhou, C., Flaws, J.A.  (2017) Effects of an environmentally relevant phthalate mixture on cultured mouse antral follicles.  Toxicological Sciences. 156(1):217-229.

Barakat, R., Lin, P-C., Rattan, S., Brehm, E.S., Canisso, I.F., Abosalum, M.E., Flaws, J.A., Hess, R., Ko, C.  (2017) Prenatal exposure to DEHP induces premature reproductive senescence in male mice.  Toxicological Sciences. 164(2):439-452.

Zhou, C., Gao, L., Flaws, J.A.  (2017) Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice.  Toxicology Applied Pharmacology 318:49-57.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2017) Factors affecting sexual function in mid-life women: Results from the Midlife Women’s Health Study.  Journal of Women’s Health. 26(9):923-932.

Chiang, C., Mahalingam, S., Flaws, J.A.  (2017)  Environmental contaminants affecting fertility and somatic health.  Seminars in Reproductive Medicine. 35(3):241-249.


Complete list of published work in my bibliography