Selected manuscripts (2021)

Chiang C, Pacyga DC, Strakovsky RS, Smith RL, James-Todd T, Williams PL, Hauser R, Meling DD, Li Z, Flaws JA. Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women’s Health Study. Environ Int. 2021 May 15;156:106633. doi: 10.1016/j.envint.2021.106633. Review.

Neff AM, Flaws JA. The effects of plasticizers on the ovary. Curr Opin Endocr Metab Res. 2021 Jun;18:35-47. doi: 10.1016/j.coemr.2021.01.004. Epub 2021 Feb 10. PMID: 33997465

Warner GR, Pacyga DC, Strakovsky RS, Smith R, James-Todd T, Williams PL, Hauser R, Meling DD, Li Z, Flaws JA. Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women. Environ Res. 2021 Mar 17;197:110891. doi: 10.1016/j.envres.2021.110891. Online ahead of print. PMID: 33722529

Mourikes VE, Flaws JA. Effects of Chemical Mixtures on the Ovary. Reproduction. 2021 Feb 1:REP-20-0587.R1. doi: 10.1530/REP-20-0587. Online ahead of print. PMID: 33528380 Review.

Warner GR, Meling DD, De La Torre KM, Wang K, Flaws JA. Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries. Biol Reprod. 2021 Apr 1;104(4):806-817. doi: 10.1093/biolre/ioab010. PMID: 33511402

Selected manuscripts (2020)

Meling DD, Warner GR, Szumski JR, Gao L, Gonsioroski AV, Rattan S, Flaws JA. The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice. Toxicol Appl Pharmacol. 2020 Feb 1;388:114875. doi: 10.1016/j.taap.2019.114875.

Warner GR, Mourikes VE, Neff AM, Brehm E, Flaws JA. Mechanisms of action of agrochemicals acting as endocrine disrupting chemicals. Mol Cell Endocrinol. 2020 Feb 15;502:110680. doi: 10.1016/j.mce.2019.110680.

Chiang C, Lewis LR, Borkowski G, Flaws JA. Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice. Reprod Toxicol. 2020 Apr;93:28-42. doi: 10.1016/j.reprotox.2019.12.006.

Chiang C, Lewis LR, Borkowski G, Flaws JA. Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse. Toxicol Appl Pharmacol. 2020 Apr 15;393:114952. doi: 10.1016/j.taap.2020.114952.

Gonsioroski A, Mourikes VE, Flaws JA. Endocrine Disruptors in Water and Their Effects on the Reproductive System. Int J Mol Sci. 2020 Mar 12;21(6). pii: E1929. doi: 10.3390/ijms21061929. Review.

Chiu K, Bashir ST, Nowak RA, Mei W, Flaws JA. Subacute exposure to di-isononyl phthalate alters the morphology, endocrine function, and immune system in the colon of adult female mice. Sci Rep. 2020 Nov 2;10(1):18788. doi: 10.1038/s41598-020-75882-0. PMID: 33139756

Brehm E, Zhou C, Gao L, Flaws JA. Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. Reprod Toxicol. 2020 Dec;98:260-268. doi: 10.1016/j.reprotox.2020.10.009. Epub 2020 Oct 28. PMID: 33129917

Selected manuscripts (2019)

Chiang, C., Flaws, J.A. Acute exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood has immediate and long-term reproductive consequences in female mice. Toxicological Sciences 2019; 168:620-631.

Rattan, S., Beers, H.K., Kannan, A., Ramakrishnan, A., Brehm, E., Bagchi, I., Irudayaraj, J.M.K., Flaws, J.A. Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries. Toxicology and Applied Pharmacology 2019; 379:114629.

Warner, G., Flaws, J.A. Commentary, Gestational diabetes and fetal programming: A mechanism for the influence of the prenatal environment on adult fertility. Endocrinology 2019; 160:2469-2470.

Gonsioroski A., Meling, D.D., Gao, L., Plewa, M.J., Flaws, J.A. Iodoacetic acid inhibits follicle growth and alters expression of genes that regulate apoptosis, the cell cycle, estrogen receptors, and ovarian steroidogenesis in mouse ovarian follicles. Reproductive Toxicology 2020 Jan;91:101-108. doi: 10.1016/j.reprotox.2019.10.005. Epub 2019 Nov 3.

Rattan S, Flaws JA. The epigenetic impacts of endocrine disruptors on female reproduction across generations. Biol Reprod. 2019 Sep 1;101(3):635-644. doi: 10.1093/biolre/ioz081.

Damdimopoulou P, Chiang C, Flaws JA. Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis. Reprod Toxicol. 2019 May 3;87:32-41. doi: 10.1016/j.reprotox.2019.04.007.

Hatcher KM, Willing J, Chiang C, Rattan S, Flaws JA, Mahoney MM. Exposure to di-(2-ethylhexyl) phthalate transgenerationally alters anxiety-like behavior and amygdala gene expression in adult male and female mice. Physiol Behav. 2019 Apr 22;207:7-14. doi:  0.1016/j.physbeh.2019.04.018.

Brehm E, Flaws JA. Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction. Endocrinology. 2019 Jun 1;160(6):1421-1435. doi: 10.1210/en.2019-00034.

Flaws JA, Warner GR. Response to the Comments of Delclos et al. Toxicol Sci. 2019 May 1;169(1):3-4. doi: 10.1093/toxsci/kfz073.

Neff AM, Blanco SC, Flaws JA, Bagchi IC, Bagchi MK. Chronic Exposure of Mice to Bisphenol-A Alters Uterine FGF Signaling and Leads to Aberrant Epithelial Proliferation. Endocrinology. 2019 May 1;160(5):1234-1246. doi: 10.1210/en.2018-00872.

Madak-Erdogan Z, Band S, Zhao YC, Smith BP, Kulkoyluoglu-Cotul E, Zuo Q, Santaliz Casiano A, Wrobel K, Rossi G, Smith RL, Kim SH, Katzenellenbogen JA, Johnson ML, Patel M, Marino N, Storniolo AMV, Flaws JA. Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling. Cancer Res. 2019 May 15;79(10):2494-2510. doi: 10.1158/0008-5472.CAN-18-2849.

Warner GR, Li Z, Houde ML, Atkinson CE, Meling DD, Chiang C, Flaws JA. Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture. Toxicol Sci. 2019 May 1;169(1):246-259. doi: 10.1093/toxsci/kfz047.

Chiang C, Flaws JA. Subchronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice. Toxicol Sci. 2019 Apr 1;168(2):620-631. doi: 10.1093/toxsci/kfz013.

Chiang C, Gallicchio L, Zacur H, Miller S, Flaws JA, Smith RL. Hormone variability and hot flash experience: Results from the midlife women’s health study. Maturitas. 2019 Jan; 119:1-7. doi: 10.1016/j.maturitas.2018.10.007.

Selected manuscripts (2018)

Smith RL, Gallicchio LM, Flaws JA. Understanding the complex relationships underlying hot flashes: a Bayesian network approach. Menopause 2018; 25:182-190.

Brehm E, Rattan S, Gao L, Flaws JA. Prenatal Exposure to Di(2-Ethylhexyl) Phthalate Causes Long-Term Transgenerational Effects on Female Reproduction in Mice. Endocrinology 2018; 159:795-809.

Rattan S, Brehm E, Gao L, Niermann S, Flaws JA. Prenatal exposure to di(2-ethylhexyl) phthalate disrupts ovarian function in a transgenerational manner in female mice. Biol Reprod 2018; 98:130-145.

Rattan S, Brehm E, Gao L, Flaws JA. Di(2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice. Toxicol Sci 2018; 63(2):420-429.

Kundu P, Patel S, Meling DD, Deal K, Gao L, Helferich WG, Flaws JA. The effects of dietary levels of genistein on ovarian follicle number and gene expression. Reprod Toxicol 2018; 81:132-139.

Richardson KA, Hannon PR, Johnson-Walker YJ, Myint MS, Flaws JA, Nowak RA. Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice. Reprod Toxicol 2018; 77:70-79.

Eckstrum KS, Edwards W, Banerjee A, Wang W, Flaws JA, Katzenellenbogen JA, Kim SH, Raetzman LT. Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development. Endocrinology 2018; 159:119-131.

Li Q, Lawrence CR, Nowak RA, Flaws JA, Bagchi MK, Bagchi IC. Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. Endocrinology 2018; 159:2216-2228.

Selected manuscripts (2016-2017)

Berger, A., Ziv-Gal A., Cudiamat, J., Wang, W., Zhou, C., Flaws, J.A.  (2016) The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice.  Reproductive Toxicology 60:39-52.

Gallicchio L., Miller S.R., Kiefer J., Greene T., Zacur H.A., Flaws, J.A. (2016) The associations between body mass index, smoking, and alcohol intake with ovarian volume in midlife women.  Journal of Women’s Health 25:409-15.

Hannon, P., Niermann, S., Flaws, J.A. (2016) Acute exposure to di(2-ethylhexyl) phthalate in adulthood causes adverse reproductive outcomes later in life and accelerates reproductive aging in female mice.  Toxicological Sciences 150:97-108.

Patel, S., Peretz, J., Pan, X-Y, Helferich, W.G., Flaws, J.A.  (2016)  Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.  Toxicology Applied Pharmacology 293:53-62.

Ziv-Gal, A., Gallicchio, L., Chiang, C., Ther, S.N., Miller, S.R., Zacur, H.A., Dills, R.L., Flaws, J.A. (2016)  Phthalate metabolite levels and menopausal hot flashes in midlife women.  Reproductive Toxicology 60:76-81.

Mahalingam, S., Gao, G., Gonnering, M., Flaws, J.A.  (2016) Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles.  Toxicology Applied Pharmacology 295:47-55.

Li, Q., Davila, J., Kannan, A., Flaws, J.A., Bagchi, M.K., Bagchi, I. C. (2016) Chronic exposures to low levels of BPA affect uterine function during early pregnancy.  Endocrinology 157:1764-74.

Gallicchio, L., Flaws, J.A., Smith, R.L.  (2016)  Age at menarche, androgen concentrations, and midlife obesity: Findings from the Midlife Women’s Health Study.  Menopause 23:1182-1188.

Smith, R.L., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A.  (2016) Risk factors for extended duration and timing of peak severity of hot flashes.  PlosOne 11:e0155079.

Jeong, C., Gao, L., Dettro, T., Wagner, E.D., Ricke, W.A., Plewa, M.J., Flaws, J.A.  (2016) Monohaloacetic acid drinking water disinfection by-products inhibit follicle growth and steroidogenesis in mouse ovarian antral follicles in vitro.  Reproductive Toxicology 62:71-76.

Ziv-Gal A., Flaws, J.A.  (2016) Evidence for bisphenol A-induced female infertility-review (2007-2016).  Fertility and Sterility 15: 827-56.

Gong, P., Madak-Erdogan, Z., Katzenellenbogen, J., Flaws, J.A., Shapiro, D.J., Katzenellenbogen, B.S. (2016) Estrogen receptor-a and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells. Molecular Cellular Endocrinology 437:190-200.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2016) Factors affecting sexual function in mid-life women: results from the midlife health study. Journal of Women’s Health 26(2):103-108.

Mahalingam, S., Gao, L., Eisner, J., Helferich, W., Flaws, J.A.  (2016) Effects of isoliquirtigenin on ovarian antral follicle growth and steroidogenesis.  Reproductive Toxicology 66:107-114.

Zhou, C., Flaws, J.A.  (2017) Effects of an environmentally relevant phthalate mixture on cultured mouse antral follicles.  Toxicological Sciences. 156(1):217-229.

Barakat, R., Lin, P-C., Rattan, S., Brehm, E.S., Canisso, I.F., Abosalum, M.E., Flaws, J.A., Hess, R., Ko, C.  (2017) Prenatal exposure to DEHP induces premature reproductive senescence in male mice.  Toxicological Sciences. 164(2):439-452.

Zhou, C., Gao, L., Flaws, J.A.  (2017) Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice.  Toxicology Applied Pharmacology 318:49-57.

Smith, R.L., Gallicchio, L., Flaws, J.A.  (2017) Factors affecting sexual function in mid-life women: Results from the Midlife Women’s Health Study.  Journal of Women’s Health. 26(9):923-932.

Chiang, C., Mahalingam, S., Flaws, J.A.  (2017)  Environmental contaminants affecting fertility and somatic health.  Seminars in Reproductive Medicine. 35(3):241-249.


Complete list of published work in my bibliography