Welcome to the Botanical Estrogen Research Center


Publications funded by or related to the UIUC Botanical Estrogens Research Center

Ali, Z., Smillie, T.J., Khan, I.A.. (2013). Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis. Nat Prod Commun. Mar;8(3):323-6. PMID: 23678801.

Ali, Z., Smillie, T.J., Khan, I.A.. (2013). 7-Oxodioscin, a new spirostan steroid glycoside from the rhizomes of Dioscorea nipponica. Nat Prod Commun. Mar;8(3):319-21. PMID: 23678800.

Ali, Z., Smillie, T.J., Khan, I.A.. (2013). Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam). Carbohydr Res. Apr 5;370:86-91. PMID: 23454141.

Bartell, S.M., Han, L., Kim, H.N., Kim, S.H., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Chambliss, K.L., Shaul, P.W., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Almeida, M., Manolagas, S.C. (2013). Non-nuclearinitiated actions of the estrogen receptor protect cortical bone mass. Mol Endocrinol. Apr;27(4):649-56. PMID: 23443267; PMCID: PMC3607700.

Turner, R.T., Iwaniec, U.T., Andrade, J.E., Branscum, A.J., Neese, S.L., Olson, D.A., Wagner, L., Wang, V.C., Schantz, S.L., Helferich, W.G. (2013). Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss. Menopause. Jun;20(6):677-86. PMID: 23385720; NIHMSID: 428029.

Neese, S.L., Bandara, S.B., Schantz, S.L.. (2013). Working memory in bisphenol-A treated middle-aged ovariectomized rats. Neurotoxicol Teratol. Jan-Feb;35:46-53. PMID: 23339879.

Kim, K., Madak-Erdogan, Z., Ventrella, R., Katzenellenbogen, B.S.. (2013). A MicroRNA196a2* and TP63 circuit regulated by estrogen receptor-α and ERK2 that controls breast cancer proliferation and invasiveness properties. Horm Cancer. Apr;4(2):78-91. PMID: 23250869; PMCID: PMC3581735.

Sepehr, E., Lebl-Rinnova, M., Mann, M.K., Pisani, S.L., Churchwell, M.I., Korol, D.L., Katzenellenbogen, J.A., Doerge, D.R. (2012). Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS. J Pharm Biomed Anal. Dec;71:119-26. PMID: 22981216; PMCID: PMC3509942.

Pisani, S.L., Neese, S.L., Doerge, D.R., Helferich, W.G., Schantz, S.L., Korol, D.L. (2012). Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats. Horm Behav. Sep;62(4):491-9. PMID: 22944517; PMCID: PMC3495242.

Park, S., Yoon, S., Zhao, Y., Park, S.E., Liao, L., Xu, J., Lydon, J.P., DeMayo, F.J., O'Malley BW, Bagchi MK, Katzenellenbogen BS. (2012). Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA. Endocrinology. Aug;153(8):3982-94. PMID: 22585830; PMCID: PMC3404350.

Li, Q., Chen, H. (2012). Silencing of Wnt5a during colon cancer metastasis involves histone modifications. Epigenetics. Jun 1;7(6):551-8. PMID: 22522911; PMCID: PMC3398984.

Bhatt, S., Xiao, Z., Meng, Z., Katzenellenbogen, B.S. (2012). Phosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF(Skp2) proteasomal complex. Mol Cell Biol. May;32(10):1928-43. PMID: 22431515; PMCID: PMC3347406.

Du, M., Yang, X., Hartman, J.A., Cooke, P.S., Doerge, D.R., Ju, Y.H., Helferich, W.G.. (2012). Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice. Carcinogenesis. Apr;33(4):895- 901. PMID: 22266527; PMCID: PMC3324438.

Madak-Erdogan, Z., Katzenellenbogen, B.S. (2012). Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140. Toxicol Sci. Feb;125(2):401-11. PMID: 22071320; PMCID: PMC3262852.

Neese, S.L., Schantz, S.L. (2012). Testosterone impairs the acquisition of an operant delayed alternation task in male rats. Horm Behav. Jan;61(1):57-66. PMID: 22047777; PMCID: PMC3308684.

Neese, S.L., Bandara, S.B., Doerge, D.R., Helferich, W.G., Korol, D.L., Schantz, S.L. (2012). Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats. Neurotoxicol Teratol. Jan-Feb;34(1):187-95. PMID: 21945133; PMCID: PMC3267004.

Stossi, F., Madak-Erdoğan, Z., Katzenellenbogen, B.S. (2012). Macrophageelicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus. Oncogene. Apr 5;31(14):1825-34. PMID: 21860415; PMCID: PMC3223561.

Bergamaschi, A., Katzenellenbogen, B.S. (2012). Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance. Oncogene. Jan 5;31(1):39-47. PMID: 21666713; PMCID: PMC3175015.

Wang, V.C., Neese, S.L., Korol, D.L., Schantz, S.L. (2011). Estradiol impairs response inhibition in young and middle-aged, but not old rats. Neurotoxicol Teratol. May-Jun;33(3):405-14. PMID: 21281713; PMCID: PMC3109186.

Minutolo, F., Macchia, M., Katzenellenbogen, B.S., Katzenellenbogen, J.A. (2011). Estrogen receptor β ligands: recent advances and biomedical applications. Med Res Rev. May;31(3):364-442. PMID: 19967775; NIHMSID: 229839.

Jeyakumar, M., Carlson, K.E., Gunther, J.R., Katzenellenbogen, J.A. Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities. J Biol. Chem., 286:12971-129782. 2011. PMID: 21321128, PMCID: PMC3075970.

Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M., Katzenellenbogen, B.S. Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs. Mol. Cell. Biol., 31:226-236, 2011. PMID: 20956553 PMCID: PMC3019850

Palchaudhuri, R.; Hergenrother, P. J. Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential. ACS Chem. Biol., 6:21-33, 2011. PMID:21105689

Li, Q. and H. Chen. Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis. Epigenetics, 6:49-852, 2011. PMID:21758003

Li, Q. and H. Chen. Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620. Clin. Exp. Metastasis, 28:127-135, 2011. PMID:21184144

Lucas, P.W.; Schmit, J.M.; Peterson, Q.P.; West, D.C.; Hsu, D.C.; Novotny, C.J.; Dirikoul, L.; Doerge, D.R.; Garrett, L.D.; Hergenrother, P.J., Fan, T.M. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for PAC-1 in Healthy Dogs. Invest. New Drugs, 29:901-911, 2011. PMID:20499133 PMCID:PMC3182491

Hsu-Rincon, A., Bray, T., Helferich, W.G., Doerge, D.R., Ho, E. Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp Biol Med., 235:90-7, 2010. PMID: 20404023

Neese, S.L., Wang, V.C., Doerge, D.R., Woodling, K.A., Andrade, J.E., Helferich, W.G., Korol, D.L., Schantz, S.L.. Impact of dietary genistein and aging on executive function in rats. Neurotoxicol Teratol., 32:200-11, 2010. PMID:19945528 PMCID: PMC2860723

Charn, T.H., Liu,E.T., Chang, E.C., Lee, Y.K., Katzenellenbogen, J.A., Katzenellenbogen, B.S. Genome-wide dynamics of chromatin binding of estrogen receptors α and β: Mutual restriction and competitive site selection. Mol Endocrinol., 24:47-59, 2010. PMID: 19897598 PMCID: PMC2802902

Stefely, J.A.; Palchaudhuri, R.; Miller, P.A.; Peterson, R.J.; Moraski, G.C.; Hergenrother, P.J.; Miller, M.J.. N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines J. Med. Chem., 53:3964-3972, 2010. PMID:20334421 PMCID:PMC2859177

Legette, L. L.; Martin, B. R.; Shahnazari, M.; Lee, W. H.; Helferich, W. G.; Qian, J.; Waters, D. J.; Arabshahi, A.; Barnes, S.; Welch, J.; Bostwick, D. G.; Weaver, C. M. Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. J Nutr., 139:1908-13, 2009. PMID:19710157 PMCID: PMC2744611

Iwaniec, U.T., Dube, M.G., Boghossian, S., Song, H., Helferich, W.G., Turner, R.T., and Kalra, S.P. Body mass influences cortical bone mass independent of leptin signaling. Bone, 44:404-12, 2009. PMID: 19095090

Stossi, F.; Madak-Erdogan, Z.; Katzenellenbogen, B.S. Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1. Mol Cell Biol., 29:1749-59, 2009. PMID:19188451 PMCID: PMC2655624

Wang, V.C., Neese, S.L., Korol, D.L., Schantz, S.L. Chronic estradiol replacement impairs performance on an operant delayed spatial alternation task in young, middle-aged, and old rats. Horm Behav., 56:382-390, 2009. PMID: 19631212 PMCID: PMC2761498.

Wang, V.C., Sable, H.J., Ju, Y.H., Allred, C.D., Helferich, W.G., Korol, D.L., Schantz, S.L. Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behav Neurosci., 122:794-804, 2008. PMID:18729633

Chang, E.C.; Charn, T.H.; Park, S.H.; Helferich, W.G.; Komm, B.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol., 22:1032-43, 2008. PMID:18258689 PMCID: 2366177

Ju, Y.H.; Doerge, D.R.; Helferich, W.G. A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food Chem Toxicol., 46:310-20, 2008. PMID:16399773

Iwaniec UT, Turner RT. Animal models for osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen CJ, editors. Osteoporosis. NY: Elsevier Press; 2008. p. 985-1009.

Ju, Y.H.; Doerge, D.R.; Woodling, K.A.; Hartman, J.A.; Kwak, J.; Helferich, W.G. Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis, 29:2162-8, 2008. PMID:18632754 PMCID: 2722859.

Madak-Erdogan, Z.; Kieser, K.J.; Kim, S.H.; Komm, B.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol Endocrinol., 22:2116-27, 2008. PMID: 18617595 PMCID:PMC2631368

Lin, C.Y.; Vega, V.B.; Thomsen, J.S.; Zhang, T.; Kong, S.L.; Xie, M.; Chiu, K.P.; Lipovich, L.; Barnett, D.H.; Stossi, F.; Yeo, A.; George, J.; Kuznetsov, V.A.; Lee, Y.K.; Charn, T.H.; Palanisamy, N.; Miller, L.D.; Cheung, E.; Katzenellenbogen, B.S.; Ruan, Y.; Bourque, G.; Wei, C.L.; Liu, E.T. Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet, 3:e87, 2007. PMID:17542648 PMCID:PMC1885282

Iwaniec, U.T.; Goblirsch, M.J.; Vrabel, A.; Ruan, M.; Clohisy, D.R.; Turner, R.T.; Oursler, M.J. 2‑Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res, 67:10106-11, 2007. PMID: 17974950

Heemstra, J.M.; Kerrigan, S.A.; Doerge, D.R.; Helferich, W.G.; Boulanger, W.A. Total synthesis of (S)-equol. Org Lett., 8:5441-3, 2006. PMID:17107042

Putt, K.S.; Chen, G.W.; Pearson, J.M.; Sandhorst, J.S.; Hoagland, M.S.; Kwon, J.T.; Hwang, S.K.; Jin, H.; Churchwell, M.I.; Cho, M.H.; Doerge, D.R.; Helferich, W.G.; Hergenrother, P.J. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol., 2:543-50, 2006. PMID:16936720

Ju, Y.H.; Fultz, J.; Allred, K.F.; Doerge, D.R.; Helferich, W.G. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis, 27:856-63, 2006. PMID:16399773

Ju, Y.H.; Allred, K.F.; Allred, C.D.; Helferich, W.G. Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations. Carcinogenesis, 27:1292-9, 2006. PMID:16537557

Harrington, W.R.; Kim, S.H.; Funk, C.C.; Madak-Erdogan, Z.; Schiff, R.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol Endocrinol., 20:491-502, 2006. PMID: 16306086

Chang, E.C.; Frasor, J.; Komm, B.; Katzenellenbogen, B.S. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology, 147:4831-42, 2006. PMID: 16809442

Allred, C.D.; Twaddle, N.C.; Allred, K.F.; Goeppinger, T.S.; Churchwell, M.I.; Ju, Y.H.; Helferich, W.G.; Doerge, D.R. Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice. J Agric Food Chem., 53:8542-50, 2005. PMID: 16248551

Rai, D.; Frolova, A.; Frasor, J.; Carpenter, A.E.; Katzenellenbogen, B.S. Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells. Mol Endocrinol., 19:1606-17, 2005. PMID: 15831524

Muthyala, R.S.; Ju, Y.H.; Sheng, S.; Williams, L.D.; Doerge, D.R.; Katzenellenbogen, B.S.; Helferich, W.G.; Katzenellenbogen, J.A. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem., 12:1559-67, 2004. PMID: 15018930

Stossi, F.; Barnett, D.H.; Frasor, J.; Komm, B.; Lyttle, C.R.; Katzenellenbogen, B.S. Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors. Endocrinology, 145:3473-862004. PMID: 15033914

Selvaraj, V.; Zakroczymski, M.A.; Naaz, A.; Mukai, M.; Ju, Y.H.; Doerge, D R.; Katzenellenbogen, J.A.; Helferich, W.G.; Cooke, P.S. Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice. Biol Reprod., 71, 966-72, 2004. PMID:15151933

Frasor, J.; Stossi, F.; Danes, J.M.; Komm, B.; Lyttle, C.R.; Katzenellenbogen, B.S. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res., 64:1522-33, 2004. PMID: 14973112

Allred, C. D.; Allred, K. F.; Ju, Y. H.; Goeppinger, T. S.; Doerge, D. R.; Helferich, W. G. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis, 25:1649-57, 2004. PMID: 15131010

Frasor, J.; Danes, J.M.; Komm, B.; Chang, K.C.; Lyttle, C.R.; Katzenellenbogen, B.S. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology, 144:4562-74, 2003. PMID: 12959972

Harrington, W.R., Sheng, S., Barnett, D.H., Petz, L.N., Katzenellenbogen, J.A., Katzenellenbogen, B.S. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol., 206:13-22, 2003. PMID: 12943986

Naaz, A.; Yellayi, S.; Zakroczymski, M.A.; Bunick, D.; Doerge, D.R.; Lubahn, D.B.; Helferich, W.G.; Cooke, P.S. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology, 144:3315-20, 2003. PMID: 12865308

Frasor, J.; Barnett, D.H.; Danes, J.M.; Hess, R.; Parlow, A.F.; Katzenellenbogen, B.S. Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology, 144:3159-66, 2003. PMID: 12810572

Harris, H.A.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta , in estrogen target tissues in vivo through the use of an ERalpha -selective ligand. Endocrinology, 143:4172-4177, 2002. PMID: 12399409

Meyers, M.J.; Sun, J.; Carlson, K.E.; Marriner, G.A.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem., 44:4230-4251, 2001. PMID: 11708925

Kraichely, D.M.; Sun, J.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology, 141:3534-3545, 2000.PMID: 11014206.

Meyers, M.J.; Sun, J.; Carlson, K.E.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J. Med. Chem., 42:2456-2468, 1999.PMID: 10395487