Welcome to the Botanical Estrogen Research Center
Publications
Publications funded by or related to the UIUC Botanical Estrogens Research Center
Yang, X., Belosay, A., Du, M., Hartman, J.A., Jackson, M., Fan, T.M., Turner, T.R., Iwaniec, U.T., and Helferich, W.G. (201X). Estradiol increased lung metastasis in a syngeneic murine model monitored by bioluminescence imaging. (Submitted)
Turner, R.T., Iwaniec, U.T., Olson, D.A., Branscum, A.J., Belosay, A., Wang, V.C., Neese, S.L., Andrade, J., Schantz, S.L., Doerge, D.R., Helferich, W.G. Physiologically Relevant Levels of Genistein Do Not Protect the Skeleton in Rat Models for Postmenopausal Bone Loss. 2012 (Submitted).
Yang, X., Belosay A., Hartman, J.A., Song H., Doerge D.R. and Helferich W.G., Estradiol increases ERα negative breast cancer metastasis in an experimental model. 2012. Clinical & Experimental Metastasis In Press.
Du, M., Yang X., Hartman J.A., Cooke, P.S., Doerge D.R., Ju Y.H., Helferich, W.G. Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice. Carcinogenesis. 33(4):895-901. 2012. PMID:22266527 PMCID: PMC3324438
Neese SL, Bandara SB, Doerge DR, Helferich WG, Korol DL, Schantz SL. Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats. Neurotoxicol Teratol. 34(1):187-95. 2011. PMID: 21945133. PMCID: PMC3267004
Jeyakumar, M., Carlson, K.E., Gunther, J.R., Katzenellenbogen, J.A. Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities. J Biol. Chem., 286:12971-129782. 2011. PMID: 21321128, PMCID: PMC3075970.
Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M., Katzenellenbogen, B.S. Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs. Mol. Cell. Biol., 31:226-236, 2011. PMID: 20956553 PMCID: PMC3019850
Palchaudhuri, R.; Hergenrother, P. J. Transcript Profiling and RNA Interference as Tools to Identify Small Molecule Mechanisms and Therapeutic Potential. ACS Chem. Biol., 6:21-33, 2011. PMID:21105689
Li, Q. and H. Chen. Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis. Epigenetics, 6:49-852, 2011. PMID:21758003
Li, Q. and H. Chen. Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620. Clin. Exp. Metastasis, 28:127-135, 2011. PMID:21184144
Lucas, P.W.; Schmit, J.M.; Peterson, Q.P.; West, D.C.; Hsu, D.C.; Novotny, C.J.; Dirikoul, L.; Doerge, D.R.; Garrett, L.D.; Hergenrother, P.J., Fan, T.M. Pharmacokinetics and Derivation of an Anticancer Dosing Regimen for PAC-1 in Healthy Dogs. Invest. New Drugs, 29:901-911, 2011. PMID:20499133 PMCID:PMC3182491
Hsu-Rincon, A., Bray, T., Helferich, W.G., Doerge, D.R., Ho, E. Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells. Exp Biol Med., 235:90-7, 2010. PMID: 20404023
Neese, S.L., Wang, V.C., Doerge, D.R., Woodling, K.A., Andrade, J.E., Helferich, W.G., Korol, D.L., Schantz, S.L.. Impact of dietary genistein and aging on executive function in rats. Neurotoxicol Teratol., 32:200-11, 2010. PMID:19945528 PMCID: PMC2860723
Charn, T.H., Liu,E.T., Chang, E.C., Lee, Y.K., Katzenellenbogen, J.A., Katzenellenbogen, B.S. Genome-wide dynamics of chromatin binding of estrogen receptors α and β: Mutual restriction and competitive site selection. Mol Endocrinol., 24:47-59, 2010. PMID: 19897598 PMCID: PMC2802902
Stefely, J.A.; Palchaudhuri, R.; Miller, P.A.; Peterson, R.J.; Moraski, G.C.; Hergenrother, P.J.; Miller, M.J.. N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines J. Med. Chem., 53:3964-3972, 2010. PMID:20334421 PMCID:PMC2859177
Legette, L. L.; Martin, B. R.; Shahnazari, M.; Lee, W. H.; Helferich, W. G.; Qian, J.; Waters, D. J.; Arabshahi, A.; Barnes, S.; Welch, J.; Bostwick, D. G.; Weaver, C. M. Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. J Nutr., 139:1908-13, 2009. PMID:19710157 PMCID: PMC2744611
Iwaniec, U.T., Dube, M.G., Boghossian, S., Song, H., Helferich, W.G., Turner, R.T., and Kalra, S.P. Body mass influences cortical bone mass independent of leptin signaling. Bone, 44:404-12, 2009. PMID: 19095090
Stossi, F.; Madak-Erdogan, Z.; Katzenellenbogen, B.S. Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1. Mol Cell Biol., 29:1749-59, 2009. PMID:19188451 PMCID: PMC2655624
Wang, V.C., Neese, S.L., Korol, D.L., Schantz, S.L. Chronic estradiol replacement impairs performance on an operant delayed spatial alternation task in young, middle-aged, and old rats. Horm Behav., 56:382-390, 2009. PMID: 19631212 PMCID: PMC2761498.
Wang, V.C., Sable, H.J., Ju, Y.H., Allred, C.D., Helferich, W.G., Korol, D.L., Schantz, S.L. Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behav Neurosci., 122:794-804, 2008. PMID:18729633
Chang, E.C.; Charn, T.H.; Park, S.H.; Helferich, W.G.; Komm, B.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol Endocrinol., 22:1032-43, 2008. PMID:18258689 PMCID: 2366177
Ju, Y.H.; Doerge, D.R.; Helferich, W.G. A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food Chem Toxicol., 46:310-20, 2008. PMID:16399773
Iwaniec UT, Turner RT. Animal models for osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen CJ, editors. Osteoporosis. NY: Elsevier Press; 2008. p. 985-1009.
Ju, Y.H.; Doerge, D.R.; Woodling, K.A.; Hartman, J.A.; Kwak, J.; Helferich, W.G. Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis, 29:2162-8, 2008. PMID:18632754 PMCID: 2722859.
Madak-Erdogan, Z.; Kieser, K.J.; Kim, S.H.; Komm, B.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol Endocrinol., 22:2116-27, 2008. PMID: 18617595 PMCID:PMC2631368
Lin, C.Y.; Vega, V.B.; Thomsen, J.S.; Zhang, T.; Kong, S.L.; Xie, M.; Chiu, K.P.; Lipovich, L.; Barnett, D.H.; Stossi, F.; Yeo, A.; George, J.; Kuznetsov, V.A.; Lee, Y.K.; Charn, T.H.; Palanisamy, N.; Miller, L.D.; Cheung, E.; Katzenellenbogen, B.S.; Ruan, Y.; Bourque, G.; Wei, C.L.; Liu, E.T. Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet, 3:e87, 2007. PMID:17542648 PMCID:PMC1885282
Iwaniec, U.T.; Goblirsch, M.J.; Vrabel, A.; Ruan, M.; Clohisy, D.R.; Turner, R.T.; Oursler, M.J. 2‑Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res, 67:10106-11, 2007. PMID: 17974950
Heemstra, J.M.; Kerrigan, S.A.; Doerge, D.R.; Helferich, W.G.; Boulanger, W.A. Total synthesis of (S)-equol. Org Lett., 8:5441-3, 2006. PMID:17107042
Putt, K.S.; Chen, G.W.; Pearson, J.M.; Sandhorst, J.S.; Hoagland, M.S.; Kwon, J.T.; Hwang, S.K.; Jin, H.; Churchwell, M.I.; Cho, M.H.; Doerge, D.R.; Helferich, W.G.; Hergenrother, P.J. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol., 2:543-50, 2006. PMID:16936720
Ju, Y.H.; Fultz, J.; Allred, K.F.; Doerge, D.R.; Helferich, W.G. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Carcinogenesis, 27:856-63, 2006. PMID:16399773
Ju, Y.H.; Allred, K.F.; Allred, C.D.; Helferich, W.G. Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations. Carcinogenesis, 27:1292-9, 2006. PMID:16537557
Harrington, W.R.; Kim, S.H.; Funk, C.C.; Madak-Erdogan, Z.; Schiff, R.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol Endocrinol., 20:491-502, 2006. PMID: 16306086
Chang, E.C.; Frasor, J.; Komm, B.; Katzenellenbogen, B.S. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology, 147:4831-42, 2006. PMID: 16809442
Allred, C.D.; Twaddle, N.C.; Allred, K.F.; Goeppinger, T.S.; Churchwell, M.I.; Ju, Y.H.; Helferich, W.G.; Doerge, D.R. Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice. J Agric Food Chem., 53:8542-50, 2005. PMID: 16248551
Rai, D.; Frolova, A.; Frasor, J.; Carpenter, A.E.; Katzenellenbogen, B.S. Distinctive actions of membrane-targeted versus nuclear localized estrogen receptors in breast cancer cells. Mol Endocrinol., 19:1606-17, 2005. PMID: 15831524
Muthyala, R.S.; Ju, Y.H.; Sheng, S.; Williams, L.D.; Doerge, D.R.; Katzenellenbogen, B.S.; Helferich, W.G.; Katzenellenbogen, J.A. Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem., 12:1559-67, 2004. PMID: 15018930
Stossi, F.; Barnett, D.H.; Frasor, J.; Komm, B.; Lyttle, C.R.; Katzenellenbogen, B.S. Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors. Endocrinology, 145:3473-862004. PMID: 15033914
Selvaraj, V.; Zakroczymski, M.A.; Naaz, A.; Mukai, M.; Ju, Y.H.; Doerge, D R.; Katzenellenbogen, J.A.; Helferich, W.G.; Cooke, P.S. Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice. Biol Reprod., 71, 966-72, 2004. PMID:15151933
Frasor, J.; Stossi, F.; Danes, J.M.; Komm, B.; Lyttle, C.R.; Katzenellenbogen, B.S. Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells. Cancer Res., 64:1522-33, 2004. PMID: 14973112
Allred, C. D.; Allred, K. F.; Ju, Y. H.; Goeppinger, T. S.; Doerge, D. R.; Helferich, W. G. Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis, 25:1649-57, 2004. PMID: 15131010
Frasor, J.; Danes, J.M.; Komm, B.; Chang, K.C.; Lyttle, C.R.; Katzenellenbogen, B.S. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology, 144:4562-74, 2003. PMID: 12959972
Harrington, W.R., Sheng, S., Barnett, D.H., Petz, L.N., Katzenellenbogen, J.A., Katzenellenbogen, B.S. Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol Cell Endocrinol., 206:13-22, 2003. PMID: 12943986
Naaz, A.; Yellayi, S.; Zakroczymski, M.A.; Bunick, D.; Doerge, D.R.; Lubahn, D.B.; Helferich, W.G.; Cooke, P.S. The soy isoflavone genistein decreases adipose deposition in mice. Endocrinology, 144:3315-20, 2003. PMID: 12865308
Frasor, J.; Barnett, D.H.; Danes, J.M.; Hess, R.; Parlow, A.F.; Katzenellenbogen, B.S. Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) alpha activity by ERbeta in the uterus. Endocrinology, 144:3159-66, 2003. PMID: 12810572
Harris, H.A.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta , in estrogen target tissues in vivo through the use of an ERalpha -selective ligand. Endocrinology, 143:4172-4177, 2002. PMID: 12399409
Meyers, M.J.; Sun, J.; Carlson, K.E.; Marriner, G.A.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem., 44:4230-4251, 2001. PMID: 11708925
Kraichely, D.M.; Sun, J.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology, 141:3534-3545, 2000.PMID: 11014206.
Meyers, M.J.; Sun, J.; Carlson, K.E.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J. Med. Chem., 42:2456-2468, 1999.PMID: 10395487