{"id":1062,"date":"2016-12-05T20:54:50","date_gmt":"2016-12-05T20:54:50","guid":{"rendered":"http:\/\/vivid7.vetmed.illinois.edu\/wp\/inoue-lab\/?page_id=2"},"modified":"2024-07-17T17:08:28","modified_gmt":"2024-07-17T22:08:28","slug":"publications","status":"publish","type":"page","link":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-background-position:left top;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-border-sizes-left:0px;--awb-border-sizes-right:0px;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:50px;--awb-padding-bottom:100px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><h2 style=\"text-align: left\">PUBLICATIONS<\/h2>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:#003e7e;border-color:#003e7e;border-top-width:5px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-padding-top:40px;--awb-padding-right:60px;--awb-padding-bottom:40px;--awb-padding-left:60px;--awb-bg-color:#ffffff;--awb-bg-color-hover:#ffffff;--awb-bg-size:cover;--awb-border-color:#e2e2e2;--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-2\" style=\"--awb-text-transform:none;\"><p>(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=vinayak%2C+sumiti&amp;sort=date\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Vinayak%2C+sumiti\" data-type=\"external\">PubMed Listing for Sumiti Vinayak<\/a>)<\/p>\n<ul>\n<li>\u00a0Nava MG, Szewczyk J, Arrington JV, Alam T, <strong>Vinayak S<\/strong>. The <em>Cryptosporidium<\/em> signaling kinase CDPK5 controls male gametogenesis and parasite virulence. <strong><em>Cell Reports<\/em><\/strong> 2024, 43: 114263<br \/>\n=&gt; <strong>Research Spotlight in<\/strong><em><strong> Trends in Parasitology <\/strong><\/em><strong><a href=\"https:\/\/www.cell.com\/trends\/parasitology\/abstract\/S1471-4922(24)00165-X\">https:\/\/www.cell.com\/trends\/parasitology\/abstract\/S1471-4922(24)00165-X<\/a><\/strong><\/li>\n<li>Gilbert IH, <b>Vinayak S<\/b>, Striepen B, Manjunatha UH, Khalil IA, Van Voorhis WC; Cryptosporidiosis Therapeutics Advocacy Group CTAG. Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease. <em><strong>BMJ Global Health<\/strong><\/em> 2023, 8: e012540.<\/li>\n<li>Nava MG, Calder\u00f3n F, Fern\u00e1ndez E, Ballell L, Bamborough P, <b><b>Vinayak S. <\/b><\/b>Tyrosine kinase inhibitors display potent activity against <em>Cryptosporidium parvum<\/em>. <em><b>Microbiology Spectrum <\/b><\/em>2023, 11: e0387422.<\/li>\n<li>Pinto DJ,<b> Vinayak S<\/b>. <em>Cryptosporidium<\/em>: host-parasite interactions and pathogenesis.<em><strong> Current Clinical Microbiology Reports<\/strong><\/em> 2021, 62-67.<\/li>\n<li><b>Vinayak S. <\/b>Recent advances in genetic manipulation of <em>Cryptosporidium<\/em>. <span class=\"docsum-journal-citation full-journal-citation\"><em><strong>Current Opinion in Microbiology<\/strong><\/em> 2020,\u00a0 58: 146-152.\u00a0<\/span><\/li>\n<li><strong>Vinayak S<\/strong>, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E. Bicyclic azetidines kill the diarrheal pathogen <em>Cryptosporidium<\/em> in mice by inhibiting parasite phenylalanyl-tRNA synthetase. <em><strong>Science Translational Medicine<\/strong> <\/em>2020, 12:eaba8412.<\/li>\n<li>Choudhary HH, Nava G, Gartlan BE, Rose S, <strong>Vinayak S<\/strong>. A conditional protein degradation system to study essential gene function in <em>Cryptosporidium parvum<\/em>. <em><strong>mBio<\/strong><\/em> 2020, 11: e01231-20.<\/li>\n<li>Sateriale A, Pawlowic M, <strong>Vinayak S<\/strong>, Striepen B. Genetic manipulation of <em>Cryptosporidium parvum<\/em> with CRISPR\/Cas9.<em><strong> Methods in Molecular Biology <\/strong><\/em>2020, 2052: 219-228.<\/li>\n<li>Baraga\u00f1a B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, <strong>Vinayak S<\/strong>, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jim\u00e9nez-D\u00edaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O&#8217;Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, M\u00e4ser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.\u00a0<strong><span class=\"jrnl\" title=\"Proceedings of the National Academy of Sciences of the United States of America\"><em>Proceedings of the National Academy of Sciences USA<\/em><\/span><\/strong>\u00a02019, 116: 7015-7020.<\/li>\n<li>Manjunatha UH*, <strong>Vinayak S<\/strong>*, Sy T, Chao AT, Noble CG, Bonamy G, Brooks CF, Herbert GT, Sateriale A, Tandel J, Kondreddi RR, Noh S, Zou B, Gedeck P, Lakshminarayana SB, Blasco F, Lim SH, Goodman LB, Yeung BKS, Bodenreider C, Simon O, Feng G, Wagner J, Leong FJ, Zambriski JA, Striepen B, Diagana TT. A Cryptosporidium PI(4)K inhibitor is a drug candidate for pediatric cryptosporidiosis.<em> <strong>Nature<\/strong><\/em> 2017, 546: 376-380 (* Equal contribution)\u200b<br \/>\n=&gt; <em><strong>Research\u00a0highlighted in:<\/strong><\/em> <em><a href=\"http:\/\/www.nature.com\/nrgastro\/journal\/v14\/n7\/full\/nrgastro.2017.81.html\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.nature.com\/nrgastro\/journal\/v14\/n7\/full\/nrgastro.2017.81.html\" data-type=\"external\">Nature Reviews Gastroenterology and Hepatology,\u00a0 <\/a><a href=\"http:\/\/www.nature.com\/nrd\/journal\/v16\/n8\/full\/nrd.2017.147.html%E2%80%8B\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.nature.com\/nrd\/journal\/v16\/n8\/full\/nrd.2017.147.html\u200b\" data-type=\"external\">Nature Drug Discovery, <\/a><a href=\"http:\/\/www.cell.com\/trends\/parasitology\/abstract\/S1471-4922(17)30167-82\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.cell.com\/trends\/parasitology\/abstract\/S1471-4922(17)30167-82\" data-type=\"external\">Trends in Parasitology<\/a><\/em><\/li>\n<li>Hulverson MA*, <strong>Vinayak S<\/strong>*, Choi R, Schaefer DA, Castellanos-Gonzalez A, Vidadala RSR, Brooks CF, Betzer DP, Whittman GR, Sparks HN, Arnold SLM, Rivas KL, Barrett LK, White AC, Maly DJ, Riggs MW, Striepen B, Voorhis WV, Ojo KK. Bumped-kinase inhibitors for the therapy of Cryptosporidiosis. <em><strong>Journal of Infectious Diseases<\/strong><\/em> 2017, 215: 1275-1284\u00a0(* Equal contribution)<\/li>\n<li>Pawlowic MC, <strong>Vinayak S<\/strong>, Sateriale A, Brooks C, Striepen B. Generating and maintaining transgenic parasites. <em><strong>Current Protocols in Microbiology<\/strong><\/em> 46: 20B.2.1-20B.2.32<\/li>\n<li>Arnold SLM *, Choi R, Hulverson MA, Schaefer DA, <strong>Vinayak S<\/strong>, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Maly DJ, Riggs MW, Striepen B, Voorhis WV. Necessity of bumped\u00a0kinase\u00a0inhibitor\u00a0gastrointestinal\u00a0exposure in treating <em>Cryptosporidium<\/em> infection. <em><strong>Journal of Infectious Diseases<\/strong><\/em>\u00a02017, 216: 55-63<\/li>\n<li><strong>Vinayak S<\/strong>*, Pawlowic MC*, Sateriale A*, Brooks CF, Studstill CJ, Bar-Peled Y, Cipriano MJ, Striepen B. Genetic modification of the diarrhoeal pathogen <em>Cryptosporidium parvum<\/em>. <em><strong>Nature<\/strong><\/em> 2015; 523:477-480\u00a0(* Equal contribution).<br \/>\n<strong><em>=&gt; <\/em>Research\u00a0highlighted in: <\/strong><a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature14636.html\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature14636.html\" data-type=\"external\">N<em>ature,\u00a0<\/em><\/a><em><a href=\"http:\/\/www.nature.com\/nrg\/journal\/vaop\/ncurrent\/full\/nrg3993.html\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.nature.com\/nrg\/journal\/vaop\/ncurrent\/full\/nrg3993.html\" data-type=\"external\">Nature Reviews Genetics,\u00a0<\/a><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471492215001749\" target=\"_blank\" rel=\"noopener noreferrer\" data-content=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471492215001749\" data-type=\"external\">Trends in Parasitology<\/a><\/em><\/li>\n<li><strong>Vinayak S<\/strong>, Brooks CF, Naumov A, Suvorova ES, White MW, Striepen B. Genetic manipulation of <em>Toxoplasma gondii<\/em> genome using fosmid recombineering. <em><strong>mBio<\/strong><\/em> 2014; 5.pii:e02021-14<\/li>\n<li>Suvorova ES, Radke JB, Ting LM, <strong>Vinayak S<\/strong>, Kratzer S, Striepen B, White MW. A nucleolar AAA-NTPase is required for parasite division. <em><strong>Molecular Microbiolog<\/strong>y<\/em> 2013; 90:338-355<\/li>\n<li>Zeeshan M, Alam MT, <strong>Vinayak S<\/strong>, Bora H, Tyagi RK, Alam MS, Choudhary V, Mittra P, Lumb V, Bharti PK, Udhayakumar V, Singh N, Jain V, Singh PP, Sharma YD. Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine. <em><strong>PLoS One<\/strong><\/em> 2012; 7:e43430<\/li>\n<li>Alam MT, de Souza DK, <strong>Vinayak S<\/strong>, Griffing SM, Poe AC, Duah N, Ghansah A, Asamoa K, Slutsker L, Wilson MD, Barnwell JW, Udhayakumar V, Koram KA. Selective sweeps and genetic backgrounds of <em>Plasmodium falciparum<\/em> drug resistance mutations in Ghana. <em><strong>Journal of Infectious Diseases<\/strong><\/em> 2011; 203:220-227<\/li>\n<li>Alam MT, <strong>Vinayak S<\/strong>, Congpuong K, Wongsrichanalai C, Satimai W, Slutsker L, Escalante AA, Barnwell JW, Udhayakumar V. Tracking the origins and spread of sulfadoxine-resistant <em>Plasmodium falciparum<\/em> dhps alleles in Thailand. <em><strong>Antimicrobial Agents and Chemotherapy<\/strong><\/em> 2011; 55:155-164<\/li>\n<li><strong>Vinayak S<\/strong>*, Alam MT*, Mixson-Hayden T, McCollum AM, Sem R, Shah NK, Lim P, Muth S, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V. Origin and evolution of sulfadoxine resistant P<em>lasmodium falciparum<\/em>. <em><strong>PLoS Pathogens\u00a0<\/strong><\/em>2010; 6:e1000830\u00a0(* Equal contribution)<\/li>\n<li>Griffing S, Syphard L, Sridaran S, McCollum AM, Mixson-Hayden T, <strong>Vinayak S<\/strong>, Villegas L, Barnwell JW, Escalante AA, Udhayakumar V. Pfmdr1 amplification and fixation of chloroquine resistant pfcrt alleles in Venezuela.<em> <strong>Antimicrobial Agents and Chemotherapy<\/strong><\/em> 2010; 54:1572-1579<\/li>\n<li><strong>Vinayak S<\/strong>, Alam MT, Sem R, Shah NK, Susanti AI, Lim P, Muth S, Maguire JD, Rogers WO, Fandeur T, Barnwell JW, Escalante AA, Wongsrichanalai C, Ariey F, Meshnick SR, Udhayakumar V. Multiple genetic backgrounds of the amplified <em>Plasmodium falciparum<\/em> multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia. <em><strong>Journal of Infectious Diseases<\/strong><\/em> 2010; 201:1551-1560 (<strong>Cover Page Article<\/strong>)<\/li>\n<li>Congpuong K, Saipomsud W, Chompoonuch C, Niemhom P, <strong>Vinayak S<\/strong>, Satimai W. Efficacy of a 3-day artesunate-mefloquine combination in the treatment of uncomplicated falciparum malaria in Kanchanaburi province of Thailand. <em><strong>Asian Biomedicine<\/strong><\/em> 2010; 4:289-295<\/li>\n<li><strong>Vinayak S<\/strong>, Rathore D, Kariuki S, Slutsker L, Shi YP, Villegas L, Escalante AA, Udhayakumar V. Limited genetic variation in the <em>Plasmodium falciparum<\/em> heme detoxification protein (HDP). <em><strong>Infection Genetics and Evolution<\/strong><\/em> 2008; 9:286-289<\/li>\n<li><strong>Vinayak S<\/strong>, Alam MT, Upadhyay M, Das MK, Dev V, Singh N, Dash AP, Sharma YD. Extensive genetic diversity in the <em>Plasmodium falciparum\u00a0<\/em>Na+\/H+ exchanger-1 transporter protein implicated in quinine resistance. <em><strong>Antimicrobial Agents and Chemotherapy<\/strong><\/em> 2007; 51:4508-4511<\/li>\n<li><strong>Vinayak S<\/strong>, Sharma YD. Inhibition of <em>Plasmodium falciparum<\/em> ispH (lytB) gene expression by hammerhead ribozyme. <em><strong>Oligonucleotides<\/strong><\/em> 2007; 17:189-200<\/li>\n<li>Vinayak S, Mittra P, Sharma YD. Wide variation in microsatellite sequences within each Pfcrt mutant haplotype. <em><strong>Molecular and Biochemical Parasitology<\/strong><\/em> 2006; 147:101-108<\/li>\n<li>Mittra P, <strong>Vinayak S<\/strong>, Chandawat H, Das MK, Singh N, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Progressive increase in point mutations associated with chloroquine resistance in <em>Plasmodium falciparum<\/em> isolates from India. <em><strong>Journal of Infectious Diseases<\/strong><\/em> 2006; 193:1304-1312<\/li>\n<li>Ahmed A, Bararia D, <strong>Vinayak S<\/strong>, Yameen M, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance. <em><strong>Antimicrobial Agents and Chemotherapy<\/strong><\/em> 2004; 48:879-889<\/li>\n<li><strong>Vinayak S<\/strong>, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD. Prevalence of the K76T mutation in the pfcrt gene of <em>Plasmodium falciparum<\/em> among chloroquine responders in India. <em><strong>Acta Tropica<\/strong><\/em> 2003; 87:287-293<\/li>\n<\/ul>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-1062","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/pages\/1062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/comments?post=1062"}],"version-history":[{"count":27,"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/pages\/1062\/revisions"}],"predecessor-version":[{"id":1863,"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/pages\/1062\/revisions\/1863"}],"wp:attachment":[{"href":"https:\/\/vetmed.illinois.edu\/vinayak-lab\/wp-json\/wp\/v2\/media?parent=1062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}