Dogs with Lymphoma, Multiple Myeloma, and Solid Tumors; Dogs with Brain Meningiomas
The University of Illinois Cancer Care Clinic and Comparative Oncology Research Laboratory recently announced two clinical trials for dogs with cancer.
Preclinical Assessment of an Oral p97 Inhibitor, CB-5339, in Tumor-Bearing Dogs
The clinical trial in tumor-bearing dogs is intended to define the safety, pharmacokinetics, and pharmacodynamic modulation of the investigational agent, CB-5339. This is designed as a dose escalation trial wherein tolerability, clinical efficacy, and pharmacokinetic/pharmacodynamic data is collected in canine solid tumors, multiple myeloma, and high-grade lymphoma.
Exploratory study of PAC-1 in combination with hydroxyurea for treatment of canine meningioma
To investigate the safety and anticancer activities of an investigational combination of chemotherapy agents in dogs with intracranial meningioma. The medication, PAC-1, has been shown to stimulate death selectively in cancer cells which express high levels of procaspase-3, and is believed to synergize with conventional brain tumor therapies inclusive of oral hydroxyurea.
Full trial announcements are available on the website at:
Please contact clinical trials coordinator Rebecca Kamerer, CVT, at 217-300-6453 or firstname.lastname@example.org to refer a patient or for any additional information. Calls from referring veterinarians and clients are welcome.