{"id":1296,"date":"2016-12-08T14:55:16","date_gmt":"2016-12-08T14:55:16","guid":{"rendered":"http:\/\/vivid7.vetmed.illinois.edu\/wp\/inoue-lab\/?p=1296"},"modified":"2025-04-10T13:52:53","modified_gmt":"2025-04-10T18:52:53","slug":"identification-of-initiator-for-neuropathic-pain","status":"publish","type":"post","link":"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/identification-of-initiator-for-neuropathic-pain\/","title":{"rendered":"Identification of initiator for neuropathic pain"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-overflow:visible;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><p>Treating neuropathic pain is indeed challenging.\u00a0 Frequent, intractable chronic pain affects ~ 1% of the U.S. population, and thus needs further study.\u00a0\u00a0 The etiology of neuropathic pain is diverse, ranging from trauma to infections to cancer.\u00a0 One circumstance that makes current treatment of neuropathic pain less-than-effective is that the underlying phenomena have yet to be fully identified and understood.\u00a0 In this regard, we have demonstrated a new molecular pathway that utilizes lipid-activated signaling in the generation of neuropathic pain by using several experimental techniques such as molecular, biological, pharmacological, immunohistochemistry, and de novo biosynthesis imaging. These techniques enabled us to discover lysophosphatidic acid acting via one of its cognate receptors, LPA<sub>1<\/sub>, which then activates both Rho A and Rho kinase (Nature Medicine 2004; Mol. Pain 2006, 2008; Neurosci. 2008; J. Neurochem. 2008).\u00a0 Identification of this pathway helped identify selected molecules that can be targeted in the treatment of neuropathic pain.<\/p>\n<p>This study was done at Nagasaki University.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":1443,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1296","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous-research"],"_links":{"self":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/comments?post=1296"}],"version-history":[{"count":5,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1296\/revisions"}],"predecessor-version":[{"id":2120,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1296\/revisions\/2120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/media\/1443"}],"wp:attachment":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/media?parent=1296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/categories?post=1296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/tags?post=1296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}