{"id":1292,"date":"2016-12-08T14:53:59","date_gmt":"2016-12-08T14:53:59","guid":{"rendered":"http:\/\/vivid7.vetmed.illinois.edu\/wp\/inoue-lab\/?p=1292"},"modified":"2025-04-10T13:51:07","modified_gmt":"2025-04-10T18:51:07","slug":"molecular-mechanisms-involving-development-of-ms-heterogeneity-using-eae","status":"publish","type":"post","link":"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/molecular-mechanisms-involving-development-of-ms-heterogeneity-using-eae\/","title":{"rendered":"Molecular mechanisms involving development of MS heterogeneity using EAE"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-overflow:visible;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><p>We study molecular mechanisms that induce heterogeneity in multiple sclerosis (MS) pathology in an effort to provide new molecular targets for the identification of biomarkers able to predict treatment outcome of therapy with interferon \u03b2 (IFN\u03b2), a well-known, first-line treatment of MS. As such, this may allow development of new personalized treatments for MS patients. We have demonstrated that NLRP3 inflammasome is a pathogenic factor in conventional types of experimental autoimmune encephalitis (termed Type-A EAE). Type-A EAE occurs by NLRP3 inflammasome-induced enhanced cell recruitment within the central nervous system (CNS) rather than via enhancing Th17 responses (PNAS 2012).\u00a0 Furthermore, we have found that IFN\u03b2 suppresses NLRP3 inflammasome activity via previously uncharacterized signaling pathways (Sci.Signal. 2012). In contrast, NLRP3-inflammasome-independent EAE (termed Type-B EAE) can thus be induced by using a system commensurable to Type-A EAE induction (Nat. Neurosci. 2016).\u00a0 Importantly, the Type-A vs. Type-B EAE models allowed study of the pathology of disease heterogeneity.\u00a0 More recently, we have discovered that Type-B EAE shows prolonged disease phenotype with irreversible neuronal loss via semaphoring 6B.\u00a0 In addition, Type-B EAE cannot be treated with IFN-\u03b2, a first-line drug to treat MS. Membrane-bound lymphotoxin-\u03b2 receptor (LT\u03b2R) and CXCR2 are involved in Type-B EAE development, and Type-B EAE is ameliorated by antagonizing the receptors. Phenotypes of Type-A and Type-B EAE may be reminiscent of relapsing-remitting MS and progressive MS, respectively. This study will be further addressed in future research.<\/p>\n<p>This study was done at Duke University under Dr. Shinohara&#8217;s supervision.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":1440,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-previous-research"],"_links":{"self":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/comments?post=1292"}],"version-history":[{"count":5,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1292\/revisions"}],"predecessor-version":[{"id":2118,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/posts\/1292\/revisions\/2118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/media\/1440"}],"wp:attachment":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/media?parent=1292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/categories?post=1292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/tags?post=1292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}