{"id":1383,"date":"2016-12-13T16:48:23","date_gmt":"2016-12-13T16:48:23","guid":{"rendered":"http:\/\/vivid7.vetmed.illinois.edu\/wp\/inoue-lab\/?page_id=1383"},"modified":"2021-01-19T18:36:56","modified_gmt":"2021-01-19T18:36:56","slug":"pi-previous-studies","status":"publish","type":"page","link":"https:\/\/vetmed.illinois.edu\/inoue-lab\/pi-previous-studies\/","title":{"rendered":"PI Previous Studies"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-equal-height-columns\" style=\"--awb-background-position:left top;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:50px;--awb-padding-bottom:90px;--awb-border-sizes-top:0px;--awb-border-sizes-bottom:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><h2>PI PREVIOUS STUDIES<\/h2>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:#003e7e;border-color:#003e7e;border-top-width:5px;\"><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-one-half fusion-column-first rounded-border\" style=\"--awb-padding-top:60px;--awb-padding-right:60px;--awb-padding-bottom:0px;;--awb-padding-left:60px;--awb-bg-color:#ffffff;--awb-bg-color-hover:#ffffff;--awb-bg-size:cover;--awb-border-color:#e2e2e2;--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;width:48%; margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-recent-posts fusion-recent-posts-1 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider floated-slideshow flexslider-hover-type-zoomin\"><ul class=\"slides\"><li><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/02\/new-drug-ms\/\" aria-label=\"New drug candidate for Multiple Sclerosis patients\" class=\"hover-type-zoomin\"><img decoding=\"async\" width=\"177\" height=\"142\" src=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-content\/uploads\/sites\/26\/2016\/12\/2news-slide2-177x142.png\" class=\"attachment-portfolio-five size-portfolio-five\" alt=\"Mechanisms of IFN beta-sensitive and resistant EAE\" data-id=\"1459\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:49:58-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/02\/new-drug-ms\/\">New drug candidate for Multiple Sclerosis patients<\/a><\/h4><p>Mechanisms of IFN beta-sensitive and resistant EAERecently, we identified new drug candidates for multiple sclerosis (MS) patients who do not respond treatment of interferon \u03b2 (IFN\u03b2), which has been a first-line treatment to MS patients for over 15 years. The study was published in the journal Nature Neuroscience (Inoue et [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-recent-posts fusion-recent-posts-2 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider floated-slideshow flexslider-hover-type-zoomin\"><ul class=\"slides\"><li><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/molecular-mechanisms-involving-development-of-ms-heterogeneity-using-eae\/\" aria-label=\"Molecular mechanisms involving development of MS heterogeneity using EAE\" class=\"hover-type-zoomin\"><img decoding=\"async\" width=\"177\" height=\"142\" src=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-content\/uploads\/sites\/26\/2016\/12\/Slide3-177x142.png\" class=\"attachment-portfolio-five size-portfolio-five\" alt=\"NLRP3 inflammasome-mediated Type-A EAE induction, which is suppressed by IFNbeta treatment\" data-id=\"1440\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:51:07-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/molecular-mechanisms-involving-development-of-ms-heterogeneity-using-eae\/\">Molecular mechanisms involving development of MS heterogeneity using EAE<\/a><\/h4><p> We study molecular mechanisms that induce heterogeneity in multiple sclerosis (MS) pathology in an effort to provide new molecular targets for the identification of biomarkers able to predict treatment outcome of therapy with interferon \u03b2 (IFN\u03b2), a well-known, first-line treatment of MS. As such, this may allow development of [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-recent-posts fusion-recent-posts-3 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider floated-slideshow flexslider-hover-type-zoomin\"><ul class=\"slides\"><li><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/t-cells-control-hyperinflammation-in-innate-immunity-during-acute-infection-model\/\" aria-label=\"T cells control hyperinflammation in innate immunity during acute infection model.\" class=\"hover-type-zoomin\"><img decoding=\"async\" width=\"177\" height=\"142\" src=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-content\/uploads\/sites\/26\/2016\/12\/Slide5-177x142.png\" class=\"attachment-portfolio-five size-portfolio-five\" alt=\"Antigen unprimed T cells control hyper inflammation\" data-id=\"1441\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:52:01-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/t-cells-control-hyperinflammation-in-innate-immunity-during-acute-infection-model\/\">T cells control hyperinflammation in innate immunity during acute infection model.<\/a><\/h4><p> Innate immunity has a protective role against pathogen infection in very early stages of infection.\u00a0 However, prolonged activation of innate immunity leads to hyperinflammation, which induces collateral damage of host tissues.\u00a0 We have demonstrated that antigen-unprimed T cells control hyperinflamamtion in innate immunity.\u00a0 This is new, because T cells [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-one-half fusion-column-last rounded-border\" style=\"--awb-padding-top:60px;--awb-padding-right:60px;--awb-padding-bottom:0px;;--awb-padding-left:60px;--awb-bg-color:#ffffff;--awb-bg-color-hover:#ffffff;--awb-bg-size:cover;--awb-border-color:#e2e2e2;--awb-border-top:1px;--awb-border-right:1px;--awb-border-bottom:1px;--awb-border-left:1px;--awb-border-style:solid;width:48%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-recent-posts fusion-recent-posts-4 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider floated-slideshow flexslider-hover-type-zoomin\"><ul class=\"slides\"><li><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/identification-of-initiator-for-neuropathic-pain\/\" aria-label=\"Identification of initiator for neuropathic pain\" class=\"hover-type-zoomin\"><img decoding=\"async\" width=\"177\" height=\"142\" src=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-content\/uploads\/sites\/26\/2016\/12\/neuro-pain-177x142.png\" class=\"attachment-portfolio-five size-portfolio-five\" alt=\"The de novo synthesized LPA induces neuropathic pain\" data-id=\"1443\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:52:53-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/identification-of-initiator-for-neuropathic-pain\/\">Identification of initiator for neuropathic pain<\/a><\/h4><p> Treating neuropathic pain is indeed challenging.\u00a0 Frequent, intractable chronic pain affects ~ 1% of the U.S. population, and thus needs further study.\u00a0\u00a0 The etiology of neuropathic pain is diverse, ranging from trauma to infections to cancer.\u00a0 One circumstance that makes current treatment of neuropathic pain less-than-effective is that the [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-recent-posts fusion-recent-posts-5 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider floated-slideshow flexslider-hover-type-zoomin\"><ul class=\"slides\"><li><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/molecular-mechanisms-on-opioid-addictiontolerance-and-anti-opioid-system\/\" aria-label=\"Molecular mechanisms on opioid addiction\/tolerance and anti-opioid system\" class=\"hover-type-zoomin\"><img decoding=\"async\" width=\"177\" height=\"142\" src=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-content\/uploads\/sites\/26\/2016\/12\/molec-mech-1-177x142.png\" class=\"attachment-portfolio-five size-portfolio-five\" alt=\"Anti-opioid system in opioid tolerance and addiction.\" data-id=\"1444\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:53:33-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/molecular-mechanisms-on-opioid-addictiontolerance-and-anti-opioid-system\/\">Molecular mechanisms on opioid addiction\/tolerance and anti-opioid system<\/a><\/h4><p> Tolerance, physical dependence, and addiction caused by chronic treatment with narcotics are important models in the study of basic neuronal plasticity. In our work, we have identified several critical molecules and pathways that are relevant to the development of peripheral and central tolerance and addiction (J.Neurosci. 2000; J. Pharmacol. [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-recent-posts fusion-recent-posts-6 avada-container layout-thumbnails-on-side layout-columns-1\"><section class=\"fusion-columns columns fusion-columns-1 columns-1\"><article class=\"post fusion-column column col col-lg-12 col-md-12 col-sm-12\"><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/author\/noliver\/\" title=\"Posts by noliver\" rel=\"author\">noliver<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-04-10T13:54:12-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/vetmed.illinois.edu\/inoue-lab\/2016\/12\/08\/in-vivo-signal-transduction-on-pain-and-analgesia\/\">In vivo signal transduction on pain and analgesia<\/a><\/h4><p> We developed a novel behavioral test to evaluate in vivo function of nociceptors, which detect endogenous nociceptive\/pain molecules in the primary afferent sensory fibers. The test using mice is sensitive enough to evaluate extremely low doses of pain inducers (PNAS 1998; J. Pharmacol. Exp. Ther. 1999, 2001, 2003; Br. [...]<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1383","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/pages\/1383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/comments?post=1383"}],"version-history":[{"count":10,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/pages\/1383\/revisions"}],"predecessor-version":[{"id":1722,"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/pages\/1383\/revisions\/1722"}],"wp:attachment":[{"href":"https:\/\/vetmed.illinois.edu\/inoue-lab\/wp-json\/wp\/v2\/media?parent=1383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}