Yoo, Dongwan
Education
PhD, University of Ottawa, Ottawa, Canada
MSc, Seoul National University, Seoul, Korea
DVM, Seoul National University, Seoul, Korea
Previous Professional Positions
Professor Special Appointment (특임교수), Seoul National University, Seoul, Korea
Visiting Professor, Leiden University Medical Center, Leiden, The Netherlands
Associate Professor, Department of Pathobiology, University of Guelph, Canada
Assistant Professor, Department of Pathobiology, University of Guelph, Canada
Medical Research Council of Canada Post-doctoral Fellow, Veterinary Infectious Disease Organization, Canada
Research Interests
Viruses infect humans, animals, plants, insects, and microbes, and many of human illnesses are caused by viruses. Animal viruses can cross species boundaries to infect human populations, and viral infections of domestic animals can cause an enormous economic and societal impact. Virus replication relies on host cell machineries, and thus during infection continuous interaction occurs between virus and host. Virology is the study of the molecular and cellular aspects of such infections and aims to develop control measures againist infections of medical and veterinary importance. We use Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Edpidemic Diarrhea Coronavirus (PEDV) as a model to study cell-virus interactions and viral evasion strategies against host immune surveillance. We have developed a reverse genetics system and using this system can generate genetically modified mutant viruses. This tool enables us to study various pathogenic mechanisms and to investigate roles that individual viral proteins play during infection.
Biography
Biography- Dr. Yoo studied Veterinary Medicine at Seoul National University in Korea. He completed his MSc in microbiology at the same institution and moved to Canada for further studies for virology in the Faculty of Health Sciences of the University of Ottawa. Following post-doctoral studies at the Vaccines and Infectious Disease Organization, Dr. Yoo was appointed Assistant Professor at Ontario Veterinary College University of Guelph where he initiated his current research on Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) as an emerged pathogen. After 11 years at Guelph, Dr. Yoo moved to the University of Illinois at Urbana-Champaign in 2006 for new challenges in his research endeavor.
- Dr. Yoo's research strengths lie in molecular virology, pathogenesis, and modern vaccinology, which forms the basis of his current research themes for two RNA viruses, an arterivirus PRRSV and a coronavirus PEDV.
Courses Taught
- Virology and Viral Pathogenesis (PATH433/ MCB433)
- Mechanisms Viral Pathogenesis (PATH519/ MCB561)
- Pathobiologic Basis of Disease II (VM607)
- Thesis Research (PATH599)
- Special Problems (PATH592)
- Undergraduate Research (PATH 290)
Selected Publications
Su C-M, Kim J, Tang J, Hung YF, Zuckermann F, Husmann R, Roady P, Kim J, Lee Y-M, Yoo D. (2024). A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen. PLOS Pathogens 20(3):e1012128.
Su CM, Du Y, Rowland RRR, Wang Q, Yoo D. (2023) Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses. Frontiers in Immunology 14:1172000.
Wu X, Hu Y, Sui C, Pan L, Yoo D, Miller L, Lee C, Cong X, Li J, Du Y, Qi J. (2022). Multiple Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication. Journal of Virology 96:e0061222.
Sui C, Jiang D, Wu X, Liu S, Li F, Pan L, Cong X, Li J, Yoo D, Rock D, Miller L, Lee C, Qi J, Du Y. (2021). Inhibition of antiviral innate immunity by foot-and-mouth disease virus Lpro through interaction with N-terminal domain of swine RNase L. Journal of Virology 95:e0036121.
Ke H, Han M, Kim J, Gustin KE, Yoo D. (2019). Porcine reproductive and respiratory syndrome virus nsp1-beta interaction with the nucleoporin 62 facilitates virus replication in vitro. Journal of Virology 93:e00469-19
(Cover page article, Volume 93, Issue 14, July 15, 2019)
Hou Y, Ke H, Kim J, Yoo D, Su Y, Boley P, Saif LJ, Wang Q. (2019). Engineering an effective and safe live attenuated PEDV vaccine candidate via inactivation of the viral 2'-O methyltransferase and the endocytosis signal of the spike protein. Journal of Virology 93:e00406-19.
Zhang Q, Ke H, Blikslager A, Fujita T, Yoo D. (2018). Type III interferon restriction by porcine epidemic diarrhea virus and the role of viral protein nsp1 in IRF1 signaling. Journal of Virology 92:e01677-17.
Han M, Ke H, Zhang Q, Yoo D. (2017). Nuclear imprisonment of host cellular mRNA by nsp1ß protein of porcine reproductive and respiratory syndrome virus. Virology 505: 42-55 (Cover page article, Volume 505, May 2017).
Lee C, Hodgins DC, Calvert JG, Welch SK, Jolie R, Yoo D. (2006). Mutations in the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication. Virology 346:238-250 (Cover page article, Volume 346, Issue 1).
Current Projects
- Immune Modulation and Evasion Strategy of PRRS Virus
- PRRS Virus as a Multivalent Vaccine Vector
- Molecular Bases for Interferon Modulation by PRRS Virus and PEDV
Grants
- USDA NIFA 2023-2027 Recombination Resistant PRRS Virus
- USDA NIFA 2018-2022 PRRS Virus Regulation for Inflammatory Regulators (PI)
- USDA HATCH, PRRS Virus as a Multivalent Vaccine Vector (PI)
- NIH T32, Infection Biology Training Program (Co-PI)
- NIH T35, Summer Training Translational Biomedical Research (Co-PI)
Honors and Awards
- Gordon and Helen Kruger Research Excellence Award (2018)
- Pfizer Award for Research Excellence (2012)
- Pfizer Faculty Award for Research Excellence (2003)
- Presidential Distinguished Professor Award (Research) (2003)
Professional Affiliations
- Editorial Board - Virology (Elsevier)
- Editorial Board - Virus Research (Elsevier)
- Editorial Board - Animal Health Research Review (Cambridge University Press)
- Associate Editor - Journal of Veterinary Science (Korean Society of Veterinary Science)
- American Society for Virology (life-time member)
- American Society for Microbiology (member)
- Conference of Research Workers in Animal Diseases (member)
Service Activities
- 18th International Nidovirus Symposium 2014, Scientific Program Committee, Spain
- International Committee on Taxonomy of Viruses, Arterivirus Study Group 2005-2011
- International Pig Veterinary Society Conference 2012 Scientific Committee, Korea
- International Pig Veterinary Society Conference 2010 Scientific Committee, Canada
- 17th International Nidovirus Symposium 2011, Scientific Program Committee, Michigan