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Quanxi Li

Research Assistant Professor, Department of Comparative Biosciences

Address and Contact Information

3411E VMBSB
2001 S Lincoln
M/C 002
Urbana, IL  61802

Education

  • PhD, Peking University, Health Science Center, Beijing, China
  • MS, Peking University, Health Science Center, Beijing, China

Research Interests

  • Steroids-regulated molecular pathways in physiological and pathological functions of the uterus.
  • Impact of environmental estrogenic toxicants and chronic inflammation on pathogenesis of female reproductive diseases.

 

Grants

U54 HD 055787, NIH/NICHD (Dr. Bagchi, MK, P.I.)

          Role in project: Principal Investigator of a pilot project

          “Role of Rac1 in uterine decidualization and implantation”

          2008-2014

R21ES024198, NIH/NIEHS

          Role in project: Principal Investigator

          "Bisphenol A, Phthalate, and Endometriosis: Mechanisms and Pathogenesis"

          2014-2017

R21ES026388, NIH/NIEHS (Dr. Nowak RA, P.I.)

          Role in project: co-Principal Investigator

          "The Role of the Peritoneum in the Pathogenesis of Endometriosis"

          2016-2018

       

      

Professional Affiliations

  • Society for Study of reproduction
  • The Endocrine Society
  • Society of Toxicology

Selected Publications

Selected publications from 2004

  • Quanxi Li, Juanmahel Davila, Milan K Bagchi, Indrani C Bagchi. Chronic exposure to bisphenol a impairs progesterone receptor-mediated signaling in the uterus during early pregnancy. Receptors & clinical investigation. 2016; 3: e1369. doi: 10.14800/rci.1369.
  • Li Y, Adur MK, Kannan A, Davila J, Zhao Y, Nowak RA, Bagchi MK, Bagchi IC, Li Q. Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model. PLoS One. 2016 Oct 24;11(10):e0165347. doi: 10.1371/journal.pone.0165347. eCollection 2016.
  • Li Q, Davila J, Kannan A, Flaws JA, Bagchi MK, Bagchi IC. Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology. 2016 May;157(5):1764-74. doi: 10.1210/en.2015-2031. Epub 2016 Mar 29
  • Davila J, Laws MJ, Kannan A, Li Q, Taylor RN, Bagchi MK, Bagchi IC.Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet.  2015 Aug 25;11(8):e1005458. doi: 10.1371/journal.pgen.1005458. eCollection 2015.
  • Zhao Y, Li Q, Katzenellenbogen BS, Taylor RN, Bagchi IC, and Bagchi MK. (2014) Estrogen-Induced CCN1 is Critical for Establishment of Endometriosis-like Lesions in Mice. MOL ENDO  2014 Dec;28(12):1934-47. doi: 10.1210/me.2014-1080.
  • Li Q*, Jones A*, Teschendorff AE*, Hayward JD, Kannan A, et al. (2013) Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development. PLoS Med 10(11): e1001551.(*, equal contribution).
  • Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, Taylor RN, Bagchi MK, Bagchi IC. (2013) WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation. Endocrinology, 154(1): 446-57.
  • Das A, Li Q, Laws MJ, Kaya H, Bagchi MK, Bagchi IC. (2012) Estrogen-induced expression of Fos-related antigen 1 (FRA-1) regulates uterine stromal differentiation and remodeling. J. Biol. Chem. 287(23):19622-30. PMCID: PMC3365997.
  • Nallasamy S, Li Q, Bagchi MK, Bagchi IC. (2012). Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. PLoS Genet. 8(2):e1002500. PMCID: PMC3285581.
  • Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. (2011) The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science, 331(6019):912-916. PMCID: PMC3320855.
  • Wang W, Li Q, Bagchi IC, Bagchi MK. (2010) The CCAAT/Enhancer binding protein β is a critical regulator of steroid-induced mitotic expansion of uterine stromal cells during decidualization. Endocrinology, 151(8): 3929-3940. PMCID: PMC2940513.
  • Kim J, Sato M, Li Q, Lydon JP, Demayo FJ, Bagchi IC, Bagchi MK. (2008) Peroxisome proliferator-activated receptor g is a target of progesterone regulation in preovulatory follicles and control ovulation in mice. Mol. Cell. Boil. 28(5):1770-82.PMCID: PMC2258771.
  • Li Q, Kannan A, Wang W, Bagchi MK, Bagchi IC. (2007) Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human. J. Biol. Chem. 282(43):31725-32.
  • Palanisamy GS, Cheon YP, Kim J. Kannan A, Li Q, Sato M, Mantena SR, Sitru-Ware RL, Bagchi MK, Bagchi IC. (2006) A Novel pathway involving progesterone receptor, endothelin-1, and endothelin receptor B controls ovulation in mice. Mol. Endo. 20(11):2784-95.
  • Li Q, Bagchi IC, Bagchi MK. (2006) Identification of a signaling pathway involving progesterone receptor, calcitonin, and tissue transglutaminase in Ishikawa endometrial cells. Endocrinology, 147(5):2147-54.
  • Mantena, SR, Kannan A, Cheon YP, Li Q, Bagchi IC, Bagchi MK. (2006) C/EBPβ is a critical mediator of steroid hormone regulated cell proliferation and differentiation in the uterine epithelium and stroma. PNAS, 103(6):1870-75.PMCID: PMC1413629.
  • Li Q, Cheon Y, Bagchi IC, Bagchi MK. (2004) A novel pathway involving progesterone receptor, 12/15-Lipoxygenase-derived eicosanoids, and peroxisome proliferator activated receptor gamma regulates implantation in mice. J. Biol. Chem. 19; 279(12): 11570-81.

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