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Lois L Hoyer

Professor, Pathobiology
Associate Dean for Research and Advanced Studies, College of Veterinary Medicine

Address and Contact Information

College of Veterinary Medicine
2001 South Lincoln Avenue
2211 Vet Med Basic Sciences Bldg
Urbana, IL  61802
(217) 244-7421 (fax)

Research Interests

My research interests focus on studies of pathogenic fungi, particularly Candida albicans.

Grants

  • Enhancing Undergraduate Research: Genome Data Mining and Laboratory Experimentation to Reveal the Fungal Agglutinin-Like Sequence Family, National Institute of Dental and Craniofacial Research, R15 DE026401. (Role: PI).
  • Summer Training in Translational Biomedical Research, Office of the Director, National Institutes of Health, T35 OD011145. (Role: PI).

Selected Publications

  • Hoyer, L.L. and E. Cota. 2016. Candida albicans agglutinin-like sequence (Als) family vignettes: a review of Als protein structure and function. Frontiers in Microbiology 7:208. doi:10.3389/fmicb.2016.00280.
  • Cota, E. and L. L. Hoyer. 2015. The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis. Future Microbiology 10:1635-1648. doi:10:2217/fmb.15.79.
  • Hoyer, L.L., S.-H. Oh, R. Jones and E. Cota. 2014. A proposed mechanism for the interaction between the Candida albicans Als3 adhesin and streptococcal cell wall proteins. Frontiers in Microbiology 5:564.
  • Hoeflinger, J., D.A. Coleman, S.-H. Oh, M. J. Miller and L.L. Hoyer. 2014. A piglet model for studying Candida albicans colonization of the human oro-gastrointestinal tract. FEMS Microbiology Letters 357:10-15.
  • Lin, J., S.-H. Oh, R. Jones, J.A. Garnett, P.S. Salgado, S. Rusnakova, S. Matthews, L.L. Hoyer and E. Cota. 2014. The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells. Journal of Biological Chemistry 289:18401-18412, doi:10.1074/jbc.M114.547877.
  • Sieklucki, U., S.-H. Oh and L.L. Hoyer. 2014. Frequent isolation of Arthroderma benhamiae from dogs with dermatophytosis. Veterinary Dermatology 25:39-e14.
  • Peters, B.M., E.S. Ovchinnikova, B.P. Krom, L.M. Schlecht, H. Zhou, L.L. Hoyer, H.J. Busscher, H.C. van der Mei, M.A. Jabra-Rizk, and M.E. Shirtliff. 2012. Staphylococcus aureus adherence to Candida albicans hyphae is mediated by the hyphal adhesin Als3p. Microbiology 158:2975-2986.
  • Murciano, C., D.L. Moyes, M. Runglall, P. Tobouti, A. Islam, L.L. Hoyer, and J.R. Naglik. 2012. Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. PLoS One 7:e33362.
  • Coleman, D.A., S.-H. Oh, S.L. Manfra-Maretta, and L.L. Hoyer. 2012. A monoclonal antibody specific for Candida albicans Als4 demonstrates overlapping localization of Als family proteins on the fungal cell surface and highlights differences between Als localization in vitro and in vivo. FEMS Immunology and Medical Microbiology 64:321-333.
  • Salgado, P.S., R. Yan, J.D. Taylor, L. Burchell, R. Jones, L.L. Hoyer, S.J. Mathews, P.J. Simpson and E. Cota. 2011. Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences USA 108:15775-15779.
  • Zhao, X. and L.L. Hoyer. 2010. ALS51, a newly discovered gene in the Candida albicans ALS family, created by intergenic recombination: analysis of the gene and protein, and implications for evolution of microbial gene families. FEMS Immunology and Medical Microbiology 61:245-257.
  • Coleman, DA, S.-H. Oh, X. Zhao, and L.L. Hoyer. 2010. Heterogeneous distribution of Candida albicans cell-surface antigens demonstrated with an Als1-specific monoclonal antibody. Microbiology 156:3645-3659.
  • Butler, G., M.D. Rasmussen, M.F. Lin, et al. 2009. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459:657-662.
  • Coleman, D.C., S.-H. Oh, X. Zhao, J.T. Hutchins, J.H. Vernachio, J.M. Patti, and L.L. Hoyer. 2009. Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces. Journal of Microbiological Methods 78:71-78.

Courses Taught

  • VM 607, Pathobiology II (Mycology unit)
  • PATH 190, Discovery Course, Journeys into the Microbial World
  • PATH 513, Biomedical Grant Proposal Writing
  • PATH 644, Bioscientific Writing
  • Summer Research Training Program for Veterinary Students
  • VM 622, Research Project I
  • VM 623, Research Project II

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