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    Indrani C Bagchi

    Professor and Assistant Head, Comparative Biosciences
    Field Chair in Reproductive Biology
    College of Veterinary Medicine

    Address and Contact Information

    College of Veterinary Medicine
    2001 South Lincoln Avenue
    3411 Vet Med Basic Sciences Bldg.
    Urbana, IL  61801

    Education

     

    • MS, India Institute of Technology, India
    • PhD, University of Nebraska
    • Postdoctoral Fellow, Baylor College of Medicine

    Research Interests

    Hormonal mechanisms regulating uterine biology:

    Molecular basis of progesterone and estrogen action in the uterus. Identification and functional characterization of estrogen and progesterone receptor-regulated pathways underlying embryo implantation. Analyses of human uterine markers in endometrial diseases, such as endometriosis and infertility.

    Hormonal mechanisms regulating ovarian functions:

    Molecular basis of progesterone receptor action in the ovary. Identification and functional characterization of progesterone receptor-regulated pathways during ovulation, using knockout mouse models.

    Development of novel contraceptives:

     Molecular mechanism of action of a novel progesterone receptor modulator Ulipristal, which prevents ovulation in women.

      Hormonal regulation of cancer:

     Analysis of the roles of steroid hormone-dependent pathways in the etiology of endometrial, ovarian and breast cancer. Use of transgenic mouse models to understand the signaling mechanisms that provoke endometrial, ovarian, and mammary epithelial cells to enter tumorigenic pathways.

     

    Honors and Awards

    National Science Talent Award, Government of India, 1975

     President’s Award, Indian Institute of Technology, Delhi, India, 1980

     Shannon Award, NICHD, NIH, 1995

     Dr. Norman and Mrs. Helen Levine Award for Research, University of Illinois at Urbana-Champaign, Urbana, 2002

     Research Excellence Award, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, 2004

     Pfizer Award for Research Excellence, University of Illinois at Urbana-Champaign, Urbana, 2005

     Billie Field Chair in Reproductive Biology, University of Illinois at Urbana-Champaign, Urbana, 2012

     

    Grants

    • U54 HD 055787, NIH/NICHD (Bagchi, MK, P.I.)

      Role in project:Principal Investigator of Subproject III

      “Regulation of stromal differentiation and implantation by the BMP2 pathway”

      2008-2014 

    •  R21 HD 078983, NIH/NICHD

      Role in project:Co-Principal Investigator with Milan Bagchi

      “Role of estrogen receptor alpha in uterine epithelial-stromal interactions”

      2014-2016

    • Penny Severns Breast, Cervical, Ovarian Cancer-Illinois Department of Public Health

      Role in project:Principal Investigator

      “Role of estrogen-dependent signaling in ovarian tumorigenesis”

      2012- 2014

    • Hatch Multistate Project, USDA

      Role in project:Principal Investigator

      “Ovarian Influences on Reproductive Success”

       2012-2017

    • Botanical Estrogen Research Center, NIH/NCCAM

      Role in project:Principal Investigator of a Pilot Project

      “Investigate the effects of genistein in a murine model of ovarian cancer”

       2012-20

    • R21 ES 024866, NIH/NIEH

       Role in project:Co-Investigator, Quanxi Li, P.I.

        “Effect of endocrine disrupting chemicals on endometriosis”

        2014-2016

    • T32 ES 007326, NIH/NIEH

       Role: Preceptor, Susan Schantz, P.I.

    •  “Training Program in Environmental Toxicology”

        2010-2015

       

    Professional Affiliations

    • Scientific Advisory Board of HRA Pharma
    • Member of Female Reproduction Focus Panel on Endometrial Biology and Diseases, Specialized Cooperative Centers Program in Reproductive research, NICHD, NIH
    • The Endocrine Society, Member of Basic Research Subcommittee (BRS)
    • Society for the Study of Reproduction
    • American Association for the Advancement of Science
    • American Society of Microbiology
    • Federation of American Societies for Experimental Biology
    • Society for Reproductive Investigation

                     

    Selected Publications

    • Selected Publications from 2010
    • Ramathal C, Bagchi I. C., Bagchi M. K. (2010) Lack of CCAAT enhancer binding protein beta (C/EBPbeta) in uterine epithelial cells impairs estrogen-induced DNA replication, induces DNA damage response pathways, and promotes apoptosis. Mol Cell Biol 30: 1607-19

       

      Ramathal C, Bagchi I. C., Taylor R. N., Bagchi M. K. (2010) Endometrial decidualization: of mice and men. Semin Reprod Med 28: 17-26

       

      Kannan A, Fazleabas A. T., Bagchi I. C., Bagchi M. K. (2010) The transcription factor C/EBPbeta is a marker of uterine receptivity and expressed at the implantation site in the primate. Reprod Sci 17: 434-43

       

      Wang W, Li Q, Bagchi I. C., Bagchi M. K. (2010) The CCAAT/enhancer binding protein beta is a critical regulator of steroid-induced mitotic expansion of uterine stromal cells during decidualization. Endocrinology 151: 3929-40

       

      Franco H. L., DaiD, LeeK. Y., RubelC. A., RoopD, BoerboomD, JeongJ-W, LydonJ. P., BagchiI. C., BagchiM. K., DeMayoF. J. (2011) WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization. FASEB J 25: 1176-1187

       

      LiQ, KannanA, DeMayoF. J., LydonJ. P., CookeP. S., SrivastavaD, BagchiM. K., BagchiI. C. (2011) The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science 331: 912-916

      Ramathal C. R., Wang W, Hunt E, Bagchi I. C., Bagchi M. K. (2011) The transcription factor C/EBPb regulates the formation of a unique extracellular matrix that controls uterine differentiation and embryo implantation J Biol Chem 286: 19860-19871

       

      Yu J, Wu J, Bagchi I. C., Bagchi M. K., Sidell N, Taylor R. N. (2011) Disruptions of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures. Mol Cell Endocrinol 344: 25-34

       

      Cooke P. S., Ekman G. C., Kaur J, Davila J, Bagchi I. C., Clark S. G., Hayashi K, Bartol F. F. (2012) Brief exposure to progesterone during a critical neonatal window prevents uterine gland formation in mice. Biol Reprod 86: 63

       

      Nallasamy S, Li Q, Bagchi M. K., and Bagchi I. C. (2012) Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. PLOS Genetics 8: e1002500.

       

      Das A, Li Q, Laws M. J., Bagchi M. K., Bagchi I. C. (2012) Estrogen-induced expression of Fos-related antigen 1 regulates uterine stromal differentiation and remodeling. J. Biol. Chem. 287: 19622-30

       

      Wang W, Taylor R. N., Bagchi I. C., and Bagchi M. K. (2012) C/EBPβ controls human endometrial stromal proliferation and differentiation by regulating cyclin E-cdk2 activity and STAT3 signaling. Mol. Endocrinol. 26: 2016-30

       

      Nallasamy S, KimJ, Sitruk-WareR, BagchiM. K., and Bagchi I. C. (2012) Ulipristal blocks ovulation by inhibiting progesterone receptor-dependent pathways intrinsic to the ovary. Reproductive Sciences 20: 371-81

       

      Li Q, Kannan A, Das A, DeMayo F. J., Hornsby P. J., Taylor R. N., Bagchi M. K., and Bagchi I. C. (2012) WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation. Endocrinology 154: 446-57

       

      Pawar S, Starosvetsky E, Orvis GD, Behringer RR, *Bagchi I. C., *Bagchi M. K.(2013) STAT3 regulates uterine epithelial remodeling and epithelial-stromal cross-talk during implantation. Mol Endocrinol, 27: 1996-2012 *Joint corresponding authors

       

      Jones A, Li Q, Teschendorff, A. E., Mould T, Zikan M, Cibula D, Fiegl H, Lee S, Wik E, Hadwin R, Arora R, Lemech C, Turunen H, Pakarinen P, Jacobs I. J., Salvesen H, Bagchi M. K., Bagchi I. C., Widschwendter M. D. (2013) Epigenetic silencing of HAND2 is a crucial step in endometrial carcinogenesis. PLOS Medicine, 10: e1001551

       

      Laws MJ, Kannan A, Pawar S, Haschek WM, Bagchi M. K., Bagchi I. C. (2013) Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice. PLOS Genetics 10:e1004230

       

      Hantak A, Bagchi I. C., and Bagchi M. K.(2014)Role of uterine stromal-epithelial crosstalk in embryo implantation. Int J Dev Biol 58: 139-146

       

      Yu J, Boicea A, Barrett K. L., James C. O., Bagchi I. C., Bagchi M. K., Nezhat C, Sidell N, Taylor R. N. (2014) Reduced connexin 43 in eutopic endometrium and cultured endometrial stromal cells from subjects with endometriosis. Mol Hum Reprod. 20: 260-70

       

      Yu J, BergaS. L., ZouW, SunH, Johnston-MacAnannyE, YalcinkayaT, SidellN, BagchiI. C., BagchiM. K., and TaylorR. N. (2014) Gap Junction Blockade Induces Apoptosis in Human Endometrial Stromal Cells. Mol Reprod Dev 81(7): 666-75

       

      Pawar S, Hantak A, *Bagchi I. C., and *Bagchi M. K.(2014) Steroid-regulated paracrine mechanisms controlling implantation. Mol Endocrinol me20141074 [Epub ahead of print] *Joint corresponding authors

       

      Zhao Y, Li Q, Katzenellenbogen B. S., Lau, L, Taylor R. N., Bagchi I. C., and Bagchi M. K. (2014) Estrogen-Induced CCN1 promotes neovascularization during establishment of endometriosis-like lesions. Mol Endocrinol (Epub)

    Courses Taught

    Reproductive Physiology in the Core Curriculum of Veterinary Medicine, VM 604.

    Advanced Endocrinology, VB 496

    Seminars in Reproductive Biology, VB 430

    Discovery Course in Reproductive Physiology, MIP 199

    Advisor of Independent study by Undergraduates, VM 299

     

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