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Bo Wang

Assistant Professor

Address and Contact Information

2001 S. Lincoln Avenue
Room 3840 VMBSB
2001 S Lincoln
Urbana, IL  61802

Education

  • PhD, The Ohio State University, Columbus, OH
  • MS, Peking Union Medical College, Beijing, China
  • BM, Shandong University, Jinan, China

Academic Positions

Postdoctoral fellow, University of California, Los Angeles

Research Interests

Our laboratory focuses on understanding the molecular mechanisms underlying lipid metabolism and human diseases. Our laboratory utilizes state-of-the-art technologies and animal models to elucidate how lipid metabolism is regulated in physiology, and how dysregulation of metabolism contributes to disease conditions, including obesity, diabetes, and cancer. Our ultimate goal is to investigate whether manipulating metabolism could be used as a therapeutic strategy for human diseases.

Grants

The Role of Lpcat3 and Phospholipid Remodeling in Intestinal Homeostasis. NIDDK

Honors and Awards

  • UCLA Atherosclerosis Research Unit George Popják Award 2018
  • Ruth L. Kirschstein National Research Service Award F32 Individual Postdoctoral Fellowship 2016-2018, NIDDK
  • American Heart Association Postdoctoral fellowship 2016
  • The Ohio State University Pelotonia Graduate Student Fellowship 2011-2012
  • The Ohio State University Distinguished University Fellowship 2006, 2010
  • Graduate of the Year Department of Pathology, The Ohio State University Medical Center 2012

Selected Publications

  1. Wang, B, Tontonoz, P. Liver X receptors in lipid signaling and membrane homeostasis. Nat Rev Endocrinol. 2018; 14: 452–463.
  2. Wang, B., Rong, X., Palladino, E.N., Wang, J., Fogelman, A.M., Martin, M.G., Alrefai, W.A., Ford, D.A., Tontonoz, P. Phospholipid remodeling and cholesterol availability regulate intestinal stemness and tumorigenesis. Cell Stem Cell. 2018;22(2):206-220.
  3. Rong, X., Wang, B., Palladino, E.N., Vallim, T., Ford, D.A., Tontonoz, P. ER Phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin. Invest. 2017;127(10):3640-3651.
  4. Wang, B., Rong, X., Duerr, M.A., Hermanson, D.J., Hedde, P.N., Wong, J.S., de Aguiar Vallim, T.Q., Cravatt, B.F., Gratton, E., Ford, D.A., Tontonoz, P. Intestinal phospholipid remodeling is required for dietary lipid uptake and survival on a high-fat diet. Cell Metab. 2016; 23 (3), 492-504.
  5. Rong, X., Wang, B., Dunham, M.M., Hedde, P.N., Wong, J.S., Gratton, E., Young, S.G., Ford, D.A., Tontonoz, P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015 Mar 25;4. doi: 10.7554/eLife.06557.
  6. Wang, B., Hsu, S.H., Wang, X., Kutay, H., Bid, H.K., Yu, J., Ganju, R.K., Jacob, S.T., Yuneva, M., Ghoshal, K. Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. Hepatology. 2014; 59(2):555-66.
  7. Hsu, S.H., Wang, B., Kutay, H., Bid, H., Shreve, J., Zhang, X., Costinean, S., Bratasz,, A., Houghton, P., Ghoshal, K. Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. Am J Pathol. 2013; 183(6):1719-30.
  8. Hsu, S.H.*, Wang, B.*, Kota, J.*, Yu, J.*, Costinean, S.*, Kutay, H.*, Yu, L.*, Bai, S.*, Perle, K.L., Chivukula, R.R., Mao, H., Wei, M., Clark, R., Mendell, J.R., Caligiuri, M.A., Jacob, S.T., Mendell, J.T., and Ghoshal, K. Essential metabolic, anti-inflammatory and anti-tumorigenic functions for miR-122 in mouse liver. J Clin. Invest. 2012; 122(8):2871-83. * Equal contribution
  9. Wang, B., Hsu, S.H., Frankel, W., Ghoshal, K., Jacob, S.T. Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1α. Hepatology. 2012; 56(1):186-97.
  10. Wang, B., Hsu, S.H., Majumder, S., Kutay, H., Huang, W., Jacob, S.T., Ghoshal, K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. 2010; 29(12):1787-97.
  11. Wang, B., Majumder, S., Nuovo, G., Kutay, H., Volinia, S., Patel, T., Schmittgen, T.D., Croce, C., Ghoshal, K., Jacob, S.T. Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology. 2009; 50(4):1152-61.

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