Directory ProfileCampus Directory Directory Search Directory Profile Profile EditorsThe following people can edit this profile: Flaws, Jodi Beuoy, Christine Eighner, Kristen Flaws, Jodi A Professor, Comparative Biosciences Department of Comparative Biosciences Address and Contact Information College of Veterinary Medicine 2001 South Lincoln Avenue 3223 Vet Med Basic Sciences Bldg.Urbana, IL 61802 (217) 333-7933 https://orcid.org/0000-0001-5579-9268 Education PhD, University of Arizona MS, Loyola University of Chicago BS, St. Xavier University Academic Positions Assistant Head, 2018-currentDepartment of Comparative Biosciences, Urbana, Illinois Interim Head, 2017-2018Department of Comparative Biosciences, Urbana, Illinois Professor, 2006-currentUniversity of Illinois, Department of Comparative Biosciences, Urbana, IllinoisDepartment of Animal Sciences (cross-appointment)Microbiome Metabolic Engineering (MME) Research Theme in the Carl R. Woese Institute for Genomic Biology (cross-appointment)Family Resiliency Center (affiliate)Beckman Institute for Advanced Science and Technology (affiliate)Division of Nutritional Sciences (zero-time appointment)Theme Co-leader, Environmental Impact on Reproductive Health (EIHR) in the Carl R. Woese Institute for Genomic Biology Division Head, 2001-2006Division of Gender-Based Epidemiology, Department of Epidemiology and Preventive Medicine, University of Maryland Associate Professor, 2001-2006University of Maryland, Program in Toxicology, Department of Epidemiology and Preventive Medicine, Baltimore, Maryland Assistant Professor, 1997-2001University of Maryland, Department of Epidemiology and Preventive Medicine,Baltimore, Maryland Postdoctoral Research Fellow, 1995-1997University of Maryland, Women’s Health Research Group and Department of Anatomy and Neurobiology, Baltimore, Maryland Postdoctoral Research Fellow, 1994-1995Johns Hopkins University, Population Dynamics, Division of Reproductive Biology, Baltimore, Maryland Research Interests The main focus of my laboratory is to determine the environmental factors that affect the female reproductive system. Specifically, the research in my laboratory is designed to address the following major questions: (1) Which genes and hormones regulate the normal development and function of the ovary? (2) What are the effects of environmental toxicants on the development and function of the ovary? (3) What are the mechanisms that underlie the effects of reproductive toxicants on the ovary? (4) Are environmental exposures associated with reproductive abnormalities in women? Links View Dr. Flaws's publications on PubMed. https://vetmed.illinois.edu/flawslab/ Courses Taught Reproductive and Developmental Toxicology Systems Toxicology VM602 Grants Research Grant Support Phthalate Exposure and Hot Flashes in Midlife Women, 5/1/17-4/30/21National Institutes of HealthPrincipal Investigator: Jodi Flaws A Collaborative Study between Brazilian and US Scientists: The Effects of Environmental Chemical Exposures on Reproduction, 4/1/18-3/31/21FAPESPPrincipal Investigator: Jodi Flaws Water Disinfection By-Products and Female FertilityNational Institutes of Health, 7/15/18-5/31/20Principal Investigator: Jodi Flaws; Co-Principal Investigator: Michael PlewaCo-Investigators: Indrani Bagchi and Lori Raetzman Phthalates and Ovarian Toxicity, 9/1/18-8/31/23National Institutes of HealthPrincipal Investigator: Jodi Flaws Phthalates in female reproduction –impact of mixture composition on hazard characterization, 4/1/19-5/31/23FORMASPrincipal Investigator: Pauliina DamdimopoulouCo-investigator: Jodi Flaws Functional and Epigenetic Effects of Preconception PCB Exposure on the Female HPG axisNational Institutes of Health, 4/1/19-3/31/24Principle Investigator: Andrea GoreSubcontract Principal Investigator: Jodi Flaws; co-PI: Lori Raetzman Effects of phthalate exposure on the gut microbiome and female reproduction, 10/1/19-9/30/20DNS-Vision 20/20Principle Investigator: Jodi Flaws Effects of phthalate exposure on the gut microbiome and female reproduction, 12/31/19-12/30/20College of Veterinary MedicinePrinciple Investigator: Jodi Flaws Training Program Support Reproductive, Endocrine Toxicology Training Grant, 7/1/15-6/30/25National Institutes of HealthDirector: Jodi FlawsCo- Director: Susan Schantz Summer Research Training Program, 9/25/15-7/31/20National Institutes of HealthCo-Director: Jodi FlawsCo-Director: Lois Hoyer Summer Undergraduate Research Experience in Toxicology (SURE Tox), 2/1/16-1/31/21National Institutes of HealthPrincipal Investigator: Jodi FlawsCo-Principal Investigator: Romana Nowak Academic Interests Endocrine, Development and Reproductive Toxicology Training Program Program in Embryology, Endocrinology, and Reproduction (PEER) Honors and Awards University Scholar, 2009-2012 Pfizer Animal Health Award for Research Excellence, 2009 Fellow of the Academy of Toxicological Sciences, 2013-current Dr. Gordon and Mrs. Helen Kruger All-Around Excellence Award Women in Toxicology Mentoring Award, Society of Toxicology Society for the Study of Reproduction Trainee Mentor Award Selected Publications Selected from 170 manuscripts Ziv-Gal, A., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A. (2012) Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors for menopausal hot flashes. American Journal of Obstetrics and Gynecology 207:202. PMID:22840970 Wang, W., Craig, Z.R., Basavarajappa, M.S., Gupta, R., Flaws, J.A. (2012) Di(2-ethylhexyl) phthalate inhibits growth of ovarian antral follicles through an oxidative stress pathway. Toxicology and Applied Pharmacology 258:288-295. PMID: 22155089 Wang, W., Craig, Z.R., Basavarajappa, M.S., Hafner, K.S., Flaws, J.A. (2012) Mono(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles. Biology of Reproduction 87(6).PMID:23077170 Peretz, J., Flaws, J.A. (2013) Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles. Toxicology Applied Pharmacology 27:249-56. PMID: 23707772 Craig, Z.R., Hannon, P., Flaws, J.A. (2013) Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor. Toxicology Applied Pharmacology (Epub ahead of print). PMID: 23948739 Ziv-Gal, A., Craig, Z.R., Wang, W., Flaws, J.A. (2013) Bisphenol A inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway. Reproductive Toxicology42C:58-67. PMID: 23928317 Craig, Z.R., Hannon, P., Wang, W., Ziv-Gal, A., Flaws, J.A. (2013) Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles. Biology of Reproduction 81(1). PMID:23242528 Wang W., Hafner K., Flaws J.A. (2014) In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse. Toxicology and Applied Pharmacology 276:157-64. PMID: 24576723 Peretz, J., Vrooman, L., Ricke, W.A., Hunt, P.A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H., Swan, S.H., VandeVoort, C., Flaws, J.A. (2014) Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence. Environmental Health Perspectives 122:775-86. PMID: 24896072. Hannon P.R., Peretz J.R., Flaws, J.A. (2014) Daily exposure to di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice. Biology of Reproduction 90:136. PMID: 24804967. Professional Affiliations Society for the Study of Reproduction Society of Toxicology Endocrine Society LDAP Details for Flaws, Jodi A