Directory Profile

• PhD, University of Arizona
• MS, Loyola University
• BS, St. Xavier University

The main focus of my laboratory is to determine the genetic and environmental factors that affect the female reproductive system. Specifically, the research in my laboratory is designed to address the following major questions: (1) Which genes and hormones regulate the normal development and function of the ovary? (2) What are the effects of environmental toxicants on the development and function of the ovary? (3) What are the mechanisms that underlie the effects of reproductive toxicants on the ovary? (4) Are environmental exposures associated with reproductive abnormalities in women?

View Dr. Flaws's publications on PubMed.

• Basic Toxicology
• Systems Toxicology
• Human Reproduction and Society
• Reproductive/Developmental Toxicology
• Structure and Function

• Endocrine, Development and Reproductive Toxicology Training Program
• Program in Embryology, Endocrinology, and Reproduction (PEER)

• Endocrine Disrupting Chemicals and Ovotoxicity, National Institutes of Health (NIEHS), 6/4/10-3/31/15
• Bisphenol A and Ovotoxicity, National Insitutes of Health (NIEHS), 10/1/11-9/30/15
• Risk Factors for Hot Flashes in Midlife, National Institutes of Health (NIA), 9/30/07-7/31/15
• Novel Methods to Assess Chemicals on Child Development, National Intitutes of Health (NIEHS) and Environmental Protection Agency (EPA), 6/15/13-6/14/18

• University Scholar, 2009-2012
• Pfizer Animal Health Award for Research Excellence, 2009
• Fellow of the Academy of Toxicological Sciences, 2013-current

Selected from 170 manuscripts

Ziv-Gal, A., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A. (2012) Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors for menopausal hot flashes. American Journal of Obstetrics and Gynecology 207:202. PMID:22840970

Wang, W., Craig, Z.R., Basavarajappa, M.S., Gupta, R., Flaws, J.A. (2012) Di(2-ethylhexyl) phthalate inhibits growth of ovarian antral follicles through an oxidative stress pathway. Toxicology and Applied Pharmacology 258:288-295. PMID: 22155089

Wang, W., Craig, Z.R., Basavarajappa, M.S., Hafner, K.S., Flaws, J.A. (2012)       Mono(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles.       Biology of Reproduction 87(6).PMID:23077170

Peretz, J., Flaws, J.A. (2013) Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles. Toxicology Applied Pharmacology 27:249-56. PMID: 23707772

Craig, Z.R., Hannon, P., Flaws, J.A. (2013) Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor. Toxicology Applied Pharmacology (Epub ahead of print). PMID: 23948739

Ziv-Gal, A., Craig, Z.R., Wang, W., Flaws, J.A. (2013) Bisphenol A inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway. Reproductive Toxicology42C:58-67. PMID: 23928317

Craig, Z.R., Hannon, P., Wang, W., Ziv-Gal, A., Flaws, J.A.       (2013) Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles.   Biology of Reproduction 81(1).       PMID:23242528

Wang W., Hafner K., Flaws J.A. (2014) In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse. Toxicology and Applied Pharmacology 276:157-64. PMID: 24576723

Peretz, J., Vrooman, L., Ricke, W.A., Hunt, P.A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H., Swan, S.H., VandeVoort, C., Flaws, J.A.       (2014) Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence. Environmental Health Perspectives 122:775-86. PMID: 24896072.

Hannon P.R., Peretz J.R., Flaws, J.A. (2014) Daily exposure to di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice. Biology of Reproduction 90:136. PMID: 24804967.

• Society for the Study of Reproduction
• Society of Toxicology
• Endocrine Society