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Department of Molecular and Integrative Physiology

Liver

Liver is the metabolic hub for nutrients, toxicants and intermediary metabolites. Our goal is to investigate how nuclear receptor signaling regulates metabolic homeostasis both in normal and diseased state using cell-based systems and genetically engineered mouse models. Currently, we are studying the role for nuclear receptors as well as bile acid signaling networks in liver cancer, diabetes and obesity.

Catherine Christian

Uterus

“The overall goal of research in my laboratory is to identify the molecular pathways regulated by the steroid hormones estrogen and progesterone during development and differentiation of key hormone-responsive tissues, including the female reproductive tract and the mammary gland.”

Learn more about Milan Bagchi

Bagchi Lab
Bagchi Lab
Bagchi Lab
Bagchi Lab
Bagchi Lab

Technical Expertise

  • Confocal microscopy
  • Conditional gene targeting
  • Uterine histology
slide Images

Prostate

“The overall goal of my laboratory is to explore the molecular, cellular and physiologic functions of hormone receptors. We are focusing on the physiologic effects of androgens on embryonic prostate development,  adult prostate homeostasis and disease.”

Learn more about Eric Bolton.

Ovary Group Image

Technical Expertise

  • Sinus and prostate organ culture
  • Signaling in the prostate
  • Cell proliferation and differentiation assay
  • IHC and Wwstern
  • qPCR
  • In silico data mining

Estrogens

“We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues.”

President of the Endocrine Society

Additional Information about Benita Katzenellenbogen.

Benita Lab Merged
Benita K Lab

Technical Expertise

  • ChIP-Seq
  • Microarray
  • miRNAs
  • RNA-Seq

 

Jongsook Kim Kemper

Gene Expression

“Using highly sensitive molecular techniques, we are studying the expression of endogenous, estrogen-responsive genes in the mouse mouse cerebral cortex. We are also using mass spectrometry to identify plasma membrane proteins as a potential targets for breast cancer diagnosis and treatment..”

Additional Information about Ann Nardulli.

Nardulli Lab
Nardulli Lab

Technical Expertise

  • 3D cell culture
  • RNA seq analysis
  • Mass spec analysis
  • Most of molecular biology techs

 

Erik Nelson

Pituitary

“Research in my laboratory is focused on understanding the role of cell-cell signaling during pituitary development. We hypothesize that the Notch signaling pathway may play an important role in the proliferation and lineage specific differentiation of progenitor cells in the embryonic pituitary.”

To learn more about Lori Ratzman's research visit Raetzman Laboratory.

Raetzman's Lab

 

Technical Expertise

  • Confocal microscopy
  • Conditional gene targeting
  • Pituitary-Hypothalamus histology
Raetzman micro

Drug Screening

“Our previous research focused on mechanisms of steroid receptor action at the transcriptional and posttranscriptional levels. In calendar year 2012, we described novel small molecule inhibitors of androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR). These small molecules are new probes for key pathways in prostate cancer, and breast, ovarian and endometrial cancer, and are being evaluated as potential anticancer drugs.”

Visit David Shapiro's Lab website.

Bagchi Lab
Bagchi Lab
Bagchi Lab
Bagchi Lab
Bagchi Lab
Targeting Estrogen Receptor (ER) Action in Breast Cancer

Technical Expertise

  • Drug screening
  • Fluorescence anisotropy microplate assay (FAMA)
  • quantitative chromatin immunoprecipitation (ChIP)

Delivery

“For more than 20 years Dr. Sherwood's laboratory has devoted research effort toward an understanding of the chemistry and physiology of relaxin. They were the first to isolate and chemically characterize relaxin and did so in two species-the rat and pig. Dr. Sherwood's laboratory then went on to determine the pattern of secretion of relaxin during pregnancy in rats and pigs and to demonstrate that the hormone has vital physiological roles during pregnancy in both species. Working in concert with estrogen, relaxin promotes growth and softening of both the cervix and the vagina and thereby enables rapid and safe delivery. Relaxin also promotes development of the mammary apparatus and thereby enables normal lactational performance.”

David Sherwood's Faculty page.

Sherwood Lab

Derek Wildman