Industrial Toxicology and Pathology Short Course
July 23-27, 2012
Champaign, Illinois
USA
| Session One: Toxicology and Pathology in Drug Discovery and Development |
Session Two: Contemporary Concepts in Target Organ Toxicologic Pathology: Renal and Respiratory Systems |
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| This session is designed for toxicologists, pathologists, and other professionals working in the pharmaceutical,
chemical, and consumer products fields with a primary emphasis on drug discovery and development. The session is also applicable to professionals responsible for design and evaluation, safety assessment, and regulatory issues associated with product development in industry, government, and contract laboratories. The objective of the session is to address current global issues in the rapidly advancing fields of toxicology and pathology; to enhance attendees' skills in interpreting animal safety studies; to facilitate interactions with federal regulatory agencies; and to provide networking opportunities. |
This session is designed for pathologists, toxicologists, and other professionals working in toxicology-related fields such as the pharmaceutical, chemical, consumer, and environmental areas. The objective of the session is to provide an understanding of the basis and manifestations of target organ responses to xenobiotic injury as well as cutting edge concepts in the field. | ||||
| Monday, July 23, 2012 | Wednesday, July 25, 2012 (afternoon) Renal System |
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| 7:00- 8:00 a.m. |
Session Check-In Continental Breakfast |
11:30 a.m.-1:00 p.m. | Session Check-In Lunch |
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| 8:00- 8:15 a.m. |
Welcome and Introduction Wanda Haschek-Hock |
Renal System | |||
| Product Developtment: From Discovery to Approval |
1:00- 2:00 p.m. |
Drug-Induced Renal Toxicity Zaher Radi, Session Chair |
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| 8:15- 9:15 a.m. |
The Pharmaceutical Industry Hugh Black |
2:00- 3:00 p.m. |
Non-Neoplastic Renal Response to Toxic Injury Gordon Hard, Keynote Speaker |
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| 9:15- 9:45 a.m. |
Break | 3:00- 3:30 p.m. |
Break | ||
| 9:45- 10:45 a.m. |
The Biotechnology Industry Noel Dybdal |
3:30- 4:30 p.m. |
Toxicant-Induced Neoplastic Renal Disease Gordon Hard |
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| 10:45- 11:45 a.m. |
General Principles of Toxicology in Drug Development Loretta Gallenberg |
4:30- 5:30 p.m. |
Drug-Induced Glomerulopathy Zaher Radi |
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| 11:45 a.m.- 1:00 p.m. |
Lunch | ||||
| 1:00- 2:00 p.m. |
Early Non-Clinical Development in Support of Drug Discovery Glenn Cantor |
Thursday, July 26, 2012 | |||
| 2:00- 3:00 p.m. |
Use of Genetically-Modified Mice in Drug Development Glenn Cantor |
7:00- 8:00 a.m. |
Continental Breakfast | ||
| 3:00- 3:30 p.m. |
Break | Renal System (continued) | |||
| 3:30- 4:30 p.m. |
The Design and Writing of the Non-Clinical Safety Report Hugh Black |
8:00- 9:00 a.m. |
Endpoints for Renal Toxicity in Non-Clinical Studies Laura Boone |
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| 4:30- 5:30 p.m. |
Panel Discussion - all speakers Glenn Cantor, Moderator |
9:00- 10:00 a.m. |
Investigative Tools of Nephrotoxicity Bruce LeRoy |
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| 5:30- 6:30 p.m. |
Reception | 10:00- 10:30 a.m. |
Break | ||
| 10:30- 11:30 a.m. |
Animal Models of Renal Disease Laura Boone |
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| Tuesday, July 24, 2012 | 11:30 a.m.- 12:00 p.m. |
Panel Discussion All Speakers Zaher Radi, Moderator |
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| 7:00- 8:00 a.m. |
Continental Breakfast | 12:00- 1:00 p.m. |
Lunch | ||
| 8:00- 9:00 a.m. |
Animal Care and Use Issues in Toxicology/Carinogenesis Research and Testing Jeff Everitt |
Respiratory System | |||
| 9:00- 10:00 a.m. |
How Laboratory Animal Science Impacts Phenotyping Pathology Sutides with Genetically Modified Rodent Models Jeff Everitt |
1:00- 1:15 p.m. |
Opening Remarks Eric Wheeldon, Session Chair |
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| 10:00- 10:30 a.m. |
Break | 1:15- 2:00 p.m. |
Current Issues in Respiratory Toxicity Jack Harkema, Keynote Speaker |
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| 10:30- 11:30 a.m. |
Pathology Issues in Study Design Ricardo Ochoa |
2:00- 3:00 p.m. |
Inhalation Toxicology: Principles and Practices Jon Hotchkiss |
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| 11:30 a.m.- 1:00 p.m. |
Lunch | 3:00- 3:30 p.m. |
Break | ||
| 1:00- 2:00 p.m. |
Reading the Rodent Bioassay: Problems, Pitfalls, and Peer Review Jerry Hardisty |
3:30- 4:30 p.m. |
Respiratory Response to Toxic Injury (Upper Respiratory Tract) Jack Harkema |
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| 2:00- 3:00 p.m. |
Diagnostic Dilemmas in Toxicologic Pathology Jerry Hardisty |
4:30- 5:30 p.m. |
Panel Discussion All Speakers Eric Wheeldon, Moderator |
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| 3:00- 3:30 p.m. |
Break | 5:30- 6:00 p.m. |
Break | ||
| 3:30- 4:30 p.m. |
Risk Management in Drug Development (I've got a safety problem, what now!) Ricardo Ochoa . |
6:00 p.m. | Dinner | ||
| 4:30- 5:30 p.m. |
Panel Discussion - all speakers Jerry Hardisty, Moderator |
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| Friday, July 27, 2012 | |||||
| Wednesday, July 25, 2012 (morning) | 7:00- 8:00 a.m. |
Continental Breakfast | |||
| 7:00- 8:00 a.m. |
Continental Breakfast | Respiratory System (continued) | |||
| 8:00- 9:00 a.m. |
Clinical Pathology for Drug Safety Studies Robert Hall |
8:00- 9:00 a.m. |
Respiratory Response to Toxic Injury (Lung) Eric Wheeldon |
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| 9:00- 10:00 a.m. |
Integration of Pathology and Toxicology in Risk Assessment: A Regulatory Viewpoint Elizabeth Hausner |
9:00- 10:00 a.m. |
Nanotechnology Products Ann Hubbs |
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| 10:00- 10:30 a.m. |
Break | 10:00- 10:30 a.m. |
Break | ||
| 10:30- 11:30 a.m. |
Emerging Issue: Metabolic Syndrome Jack Harkema |
10:30 -11:30 a.m. |
Respiratory Lesions from National Toxicology Program (NTP) Studies Mark Cesta |
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| 11:30 a.m.- 1:00 p.m. |
Lunch | 11:30 a.m.-12:00 p.m. | Panel Discussion All Speakers Eric Wheeldon, Moderator |
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All speakers and titles are subject to change.