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University of Illinois at Urbana-Champaign

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Industrial Toxicology and Pathology Short Course

July 23-27, 2012
Champaign, Illinois
USA

 

  Session One:
Toxicology and Pathology
in Drug Discovery and Development
  Session Two:
Contemporary Concepts in
Target Organ Toxicologic Pathology:
Renal and Respiratory Systems
  This session is designed for toxicologists, pathologists, and other professionals working in the pharmaceutical, chemical, and consumer products fields with a primary emphasis on drug discovery and development. The session is also applicable to professionals responsible for design and evaluation, safety assessment, and regulatory issues associated with product development in industry, government, and contract laboratories. The objective of the session is to address current global issues in the rapidly advancing fields of toxicology and pathology; to enhance attendees' skills in interpreting animal safety
studies; to facilitate interactions with federal regulatory agencies; and to provide networking opportunities.
  This session is designed for pathologists, toxicologists, and other professionals working in toxicology-related fields such as the pharmaceutical, chemical, consumer, and environmental areas. The objective of the session is to provide an understanding of the basis and manifestations of target organ responses to xenobiotic injury as well as cutting edge concepts in the field.
  Monday, July 23, 2012   Wednesday, July 25, 2012 (afternoon)
Renal System
  7:00-
8:00 a.m.
Session Check-In
Continental Breakfast
  11:30 a.m.-1:00 p.m. Session Check-In
Lunch
  8:00-
8:15 a.m.
Welcome and Introduction
Wanda Haschek-Hock
  Renal System
  Product Developtment:
From Discovery to Approval
  1:00-
2:00 p.m.
Drug-Induced Renal Toxicity
Zaher Radi, Session Chair
  8:15-
9:15 a.m.
The Pharmaceutical Industry
Hugh Black
  2:00-
3:00 p.m.
Non-Neoplastic Renal Response
to Toxic Injury

Gordon Hard, Keynote Speaker
  9:15-
9:45 a.m.
Break   3:00-
3:30 p.m.
Break
  9:45-
10:45 a.m.
The Biotechnology Industry
Noel Dybdal
  3:30-
4:30 p.m.
Toxicant-Induced
Neoplastic Renal Disease

Gordon Hard
  10:45-
11:45 a.m.
General Principles of Toxicology
in Drug Development

Loretta Gallenberg
  4:30-
5:30 p.m.
Drug-Induced Glomerulopathy
Zaher Radi
  11:45 a.m.-
1:00 p.m.
Lunch    
  1:00-
2:00 p.m.
Early Non-Clinical Development
in Support of Drug Discovery

Glenn Cantor
  Thursday, July 26, 2012
  2:00-
3:00 p.m.
Use of Genetically-Modified Mice
in Drug Development

Glenn Cantor
  7:00-
8:00 a.m.
Continental Breakfast
  3:00-
3:30 p.m.
Break   Renal System (continued)
  3:30-
4:30 p.m.
The Design and Writing
of the Non-Clinical Safety Report

Hugh Black
  8:00-
9:00 a.m.
Endpoints for Renal Toxicity in Non-Clinical Studies
Laura Boone
  4:30-
5:30 p.m.
Panel Discussion - all speakers
Glenn Cantor, Moderator
  9:00-
10:00 a.m.
Investigative Tools of Nephrotoxicity
Bruce LeRoy
  5:30-
6:30 p.m.
Reception   10:00-
10:30 a.m.
Break
      10:30-
11:30 a.m.
Animal Models of Renal Disease
Laura Boone
  Tuesday, July 24, 2012   11:30 a.m.-
12:00 p.m.
Panel Discussion
All Speakers
Zaher Radi, Moderator
  7:00-
8:00 a.m.
Continental Breakfast   12:00-
1:00 p.m.
Lunch
  8:00-
9:00 a.m.
Animal Care and Use Issues in Toxicology/Carinogenesis Research and Testing
Jeff Everitt
  Respiratory System
  9:00-
10:00 a.m.
How Laboratory Animal Science Impacts Phenotyping Pathology Sutides with Genetically Modified Rodent Models
Jeff Everitt
  1:00-
1:15 p.m.
Opening Remarks
Eric Wheeldon, Session Chair
  10:00-
10:30 a.m.
Break   1:15-
2:00 p.m.
Current Issues in Respiratory Toxicity
Jack Harkema, Keynote Speaker
  10:30-
11:30 a.m.
Pathology Issues in Study Design
Ricardo Ochoa
  2:00-
3:00 p.m.
Inhalation Toxicology: Principles and Practices
Jon Hotchkiss
  11:30 a.m.-
1:00 p.m.
Lunch   3:00-
3:30 p.m.
Break
  1:00-
2:00 p.m.
Reading the Rodent Bioassay: Problems, Pitfalls, and Peer Review
Jerry Hardisty
  3:30-
4:30 p.m.
Respiratory Response to Toxic Injury (Upper Respiratory Tract)
Jack Harkema
  2:00-
3:00 p.m.
Diagnostic Dilemmas in
Toxicologic Pathology

Jerry Hardisty
  4:30-
5:30 p.m.
Panel Discussion
All Speakers
Eric Wheeldon, Moderator
  3:00-
3:30 p.m.
Break   5:30-
6:00 p.m.
Break
  3:30-
4:30 p.m.
Risk Management in Drug Development (I've got a safety problem, what now!)
Ricardo Ochoa .
  6:00 p.m. Dinner
  4:30-
5:30 p.m.
Panel Discussion - all speakers
Jerry Hardisty, Moderator
   
      Friday, July 27, 2012
  Wednesday, July 25, 2012 (morning)   7:00-
8:00 a.m.
Continental Breakfast
  7:00-
8:00 a.m.
Continental Breakfast   Respiratory System (continued)
  8:00-
9:00 a.m.
Clinical Pathology
for Drug Safety Studies

Robert Hall
  8:00-
9:00 a.m.
Respiratory Response to Toxic Injury (Lung)
Eric Wheeldon
  9:00-
10:00 a.m.
Integration of Pathology and Toxicology in Risk Assessment: A Regulatory Viewpoint
Elizabeth Hausner
  9:00-
10:00 a.m.
Nanotechnology Products
Ann Hubbs
  10:00-
10:30 a.m.
Break   10:00-
10:30 a.m.
Break
  10:30-
11:30 a.m.
Emerging Issue: Metabolic Syndrome
Jack Harkema
  10:30
-11:30 a.m.
Respiratory Lesions from National Toxicology Program (NTP) Studies
Mark Cesta
  11:30 a.m.-
1:00 p.m.
Lunch   11:30 a.m.-12:00 p.m. Panel Discussion
All Speakers
Eric Wheeldon, Moderator

All speakers and titles are subject to change.