Publications 2017-08-31T14:34:05+00:00

PUBLICATIONS

PUBLICATIONS

    1. Lau G, Chao CT, Ellingboe AH. 1993. Interaction of genes controlling avirulence/virulence of Magnaporthe grisea on rice cultivar Katy. Phytopathology 83: 375-382.
    2. Lau G, Ellingboe, AH. 1993. Genetic analysis of mutations to increased virulence in Magnaporthe grisea. Phytopathology 83: 1093-1096.
    3. Andrews J, Harris R, Spear R, Lau G, Nordhein E. 1994. Morphogenesis and Adhesion of Aureobasidium pullulans. Can J Microbiol 40: 6-17.
    4. Lau GW, Hamer JE. 1996. Regulatory genes controlling MPG1 expression and pathogenecity in the rice blast fungus Magnaporthe grisea. Plant Cell 8: 771-781.
    5. Lau GW, Hamer JE. 1998. Acropetal, a genetic locus required for conidiophore architecture and pathogenicity in the rice blast fungus. Fungal Genet and Biol 24: 228-239.
    6. Nishimura M, Hayashi N, Jwa N-S, Lau GW, Hamer JE, Hasebe A. 2000. LINE retrotransposon MGL causes conidium morphogenetic mutation in Magnaporthe grisea. Mol Plant Microbe Interact 13: 892-894.
    7. Rahme L, Ausubel F, Cao H, Drenkard E, Goumneov B, Lau GW, Plotnikova J, Tompkins R, Tsongalis J, Walendziewicz C. 2000. Plants and animals share functionally common bacterial virulence factors. Proc Natl Acad Sci U S A 97: 8815-8821.
    8. Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, Bryant AP, McDevitt D, Morrison DA, Holden DW. 2001. A functional genomics of type III Streptococcus pneumoniae virulence. Mol Microbiol 40: 555-571.
    9. Baldini R, Lau GW, Rahme L. 2002. The use of plant and insect hosts to model bacterial pathogenesis. Methods Enzymol 358: 3-13.
    10. Ran H, Hassett DJ, Lau GW. 2003. Human Targets of Pseudomonas aeruginosa pyocyanin. Proc Natl Acad Sci U S A 100: 14315-14320 (Track II).
    11. Potvin E, Lehoux D, Kukavica-Ibrujl I, Richard K, Sanschagrin F, Lau GW, Levesque RC. 2003. In vivo functional genomics of Pseudomonas aeruginosa for high throughput screening of novel virulence factors and antibacterial targets. Environ Microbiol 5: 1294-1308.
    12. Lau GW, Ran H, Kong FS, Hassett DJ, Mavrodi D. 2004. Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. Infect Immun 72: 4275-4278.
    13. Lau GW, Ran H, Hassett DJ, Kong FS. 2004. The role of pyocyanin in Pseudomonas aeruginosa infection. Trends Mol Med 10: 599-606.
    14. Lau GW, Britigan BE, Hassett DJ. 2005. Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils. Infect Immun 73: 2550-2553.
    15. Apidianakis Y, Mindrinos M, Xiao W, Lau GW, Baldini R, Davis RW, Rahme LG. 2005. Profiling early host response to infection: Pseudomonas aeruginosa potentiates disease by restricting antimicrbial peptide gene expression. Proc Natl Acad Sci U S A 102: 2573-2578.
    16. Lau GW, Hassett DJ, Britigan BE. 2005. Modulation of lung epithelial functions by Pseudomonas aeruginosa. Trends Microbiol 13: 389-397.
    17. Zhang S, Chen Y, Potvin E, Sanschagrin F, Levesque RC, McCormack FX, Lau GW. 2005. Comparative signature-tagged mutagenesis identifies Pseudomonas aeruginosa factors conferring resistance to pulmonary collectin SP-A. PLoS Pathog 1: e31.
    18. Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ. 2006. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. J Clin Invest 116: 436-446.
    19. Kong FS, Young LE, Ran H, Meyers M, Chen Y, Joseph P, Hassett DJ, Lau GW. 2006. Pseudomonas aeruginosa pyocyanin inactivates lung epithelial vaculoar ATPase-dependent CFTR expression and localization. Cell Microbiol 8: 1121-1133.
    20. Borchers MT, Harris NL, Wesselkamper SC, Chen Y, Zhang S, Young L, Lau GW. 2006. The NKG2D activating receptor mediates pulmonary clearance of Pseudomonas aeruginosa. Infect Immun 74: 2578-2586.
    21. Zhang S, McCormack FX, Levesque RC, O’Toole G, Lau GW. The flagellar protein, FlgE, is a molecular target for clearance of Pseudomonas aeruginosa by SP-A. PLoS One 2: e564.
    22. Heo Y-J, Chung I-Y, Choi KB, Lau GW, Cho YH. 2007. Genome sequence comparison and superinfection between two related Pseudomonas aeruginosa phages, D3112 and MP22. Microbiology 153: 2885-2895.
    23. Platt MD, Schurr MJ, Sauer K, Vazquez G, Kukavica-Ibrulj I, Potvin E, Levesque RC, Fedynak A, Brinkman FSL, Schurr J, Hwang SH, Lau GW Limbach PA, Rowe JJ, Lieberman MA, Barraud N, Webb J, Kjelleberg S, Hunt DF, Hassett DJ. 2008. Proteomic, microarray and signature tagged mutagenesis analysis of anaerobic Pseudomonas aeruginosa at pH 6.5, representing chronic cystic fibrosis airway conditions. J Bacteriol 190: 2739-2758.
    24. Wesselkamper SC, Eppert BL, Motz GT, Lau GW, Hassett DJ, Borchers MT. 2008. NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection. J Immunol 181: 5481-5489.
    25. Cheluvappa R, Denning G, Lau GW, Grimm M, Hilmer S, Le Couter D. 2009. Pseudomonas aeruginosa and the hyperlipidemia of sepsis. Pathology 41: 615-621.
    26. Caldwell CC, Chen Y, Goetzmann H, Hao H, Borchers MT, Hassett DJ, Young LR, Mavrodi D, Thomashow L, Lau GW. 2009. Pseudomonas aeruginosa pyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol 175: 2473-88.
    27. Kim S-H, Lee B-Y, Lau GW, Cho Y-H. 2009. IscR modulates catalase A (KatA) activity, peroxide resistance, and full virulence of Pseudomonas aeruginosa PA14. J Microbiol Biotechnol 19: 1520-1526.
    28. Hassett DJ, Korfhagen TR, Irvin RT, Schurr MJ, Sauer K, Lau GW, Sutton M, Hoiby N. 2010. Pseudomonas aeruginosa Biofilm Infections in Cystic Fibrosis: Insights Into Pathogenic Processes and Treatment Strategies. Expert Opin Ther Targets 14: 117-130.
    29. Cheluvappa R, Denning G, Lau GW, Grimm M, Hilmer S, D Le Couter. 2010. Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. Int J Infect Dis 14: e857-867.
    30. Kuang ZZ, YH Hao, SH Hwang, S Zhang, E Kim, HT Akinbi, MJ Schurr, RT Irvin, DJ Hassett and Lau GW. 2011. The flagella of Pseudomonas aerugniosa mediate resistance to SP-A-mediated membrane permeabilization by multiple mechanisms. Mol Microbiol 79:1220-1235.
    31. Kuang Z, Hao Y, Walling BE, Jeffries JL, Ohman DE, Lau GW. 2011. Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A. PLoS ONE 6:e27091. Top 10% most cited PLOS ONE articles.
    32. Zhu L, Lau GW. 2011. Inhibition of competence development, horizontal gene transfer and virulence in Streptococcus pneumoniae by a modified competence stimulating peptide. PLoS Pathog 7(9):e1002241.
    33. Duan C, Zhu L, Xu Y, Lau GW. 2012. Saturated alanine scanning mutagenesis of the pneumococcus competence stimulating peptide identifies analogs that inhibit genetic transformation. PLoS ONE 7(9):e44710.
    34. Hao Y, Kuang Z, Walling BE, Bhatia S, Sivaguru M, Chen Y, Gaskins HR, Lau GW. 2012. Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2. Cell Microbiol 14:401-15.
    35. Zhu L, Lau GW. 2013. Therapeutic potential of the Streptococcus pneumoniae competence regulon. Expert Rev Anti-Infect Ther 11:227-9.
    36. Zhu L, Kuang Z, Wilson BA, Lau GW. 2013. Competence-independent activity of pneumococcal EndA mediates degradation of extracellular DNA and NETs and is important for virulence. PLoS ONE 8(7):e70363.
    37. Hao Y, Kuang Z, Xu Y, Walling BE, Lau GW. 2013. Pyocyanin-induced mucin production is associated with redox modification of FOXA2. Respir Res 14:82.
    38. Xu Y, Duan C, Kuang Z, Hao Y, Jeffries JL, Lau GW. 2013. Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells. PLoS ONE 8(8): e72528.
    39. Walling BE, Kuang Z, Hao Y, Estrada D, Wood JD, Lian F, Miller LA, Shah AB, Jeffries JL, Haasch RT, Lyding JW, Pop E, Lau GW. 2013. Helical carbon nanotubes enhance the early immune response and inhibit macrophage-mediated phagocytosis of Pseudomonas aeruginosa. PLoS ONE 8(11):e80283.
    40. Tan RM, Kuang Z, Hao Y, Lau GW. 2014. Type IV Pilus of Pseudomonas aeruginosa Confers Resistance to Antimicrobial Activities of the Pulmonary Surfactant Protein-A. J Innate Immun 6: 227-239.
    41. Walling BE, Lau GW. 2014. Perturbation of pulmonary immune functions by carbon nanotubes and susceptibility to microbial infection. J Microbiol 52:227-34. Invited review.
    42. Li Y, Petrova OE, Su S, Lau GW, Panmanee W, Na R, Hassett DJ, Davies DG, Sauer K. 2014. BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa. PLoS Pathog 10(6):e1004168.
    43. Hao Y, Kuang Z, Jing J, Miao J, Mei LY, Lee RJ, Kim S, Choe S, Krause DC, Lau GW. 2014. Mycoplasma pneumoniae modulates the STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins”. Infect Immun 82:5246-55.
    44. Jin Z, Chung JW, Mei W, Strack S, He C, Lau GW, J Yang. 2015. Regulation of nuclear- cytoplasmic shuttling of Family with sequence similarity 13, member A (Fam13a) by B56-containing PP2As and Akt. Mol Biol Cell 26:1160-73.
    45. Tan RM, Kuang Z, Hao Y, Lee RJ, Kim S, Lau GW. 2015. Type IV pilus glycosylation mediates resistance of Pseudomonas aeruginosa against opsonic activities of the pulmonary surfactant proteins. Infect Immun 83(4):1339-46.
    46. Walling BE, Kuang ZZ, Hao YH, Gastouniotis C, Lau GW. 2015. Helical carbon nanotubes alter F-actin and ARP2 distribution in macrophages and inhibit Pseudomonas aeruginosa phagocytosis in an intracellular accumulation-dependent manner. J Nanomed Res 2(1):00019.
    47. Parkinson EI, Nakamura BA, Bair J, Lau GW, Hergenrother PJ. 2015. Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria. Nat Commun 6:6947.
    48. Zhu L, Lin J, Kuang Z, Vidal, J, Lau GW. 2015. Deletion analysis of Streptococcus pneumoniae late competence genes distinguishes virulence determinants that are dependent or independent of competence induction. Mol Microbiol 97(1):151-65.
    49. Lin JJ, Zhu L, Lau GW. 2016. Disentangling competence for genetic transformation and virulence in Streptococcus pneumoniae. Curr Genet 62:97-103. Invited review.
    50. Jeffries JL, Jia J, Choi WS, Choe S, Miao J, Xu Y, Hao Y, Kuang Z, Powell R, Lin J, Z Kuang, Gaskins HR, Lau GW. 2016. Pseudomonas aeruginosa pyocyanin modulates mucin glycosylation with sialyl-Lewis-x to increase binding to airway epithelial cells. Mucosal Immunol 9:1039-50.
    51. Huang L, Luo X, Shao J, Yan H, Qiu Y, Ke P, Zheng W, Xu B, Li W, Sun D, Cao D, Chen C, Zhuo F, Lin X, Tang F, Bao B, Zhou Y, Zhang X, Li H, Li J, Wan D, Yang L, Chen Y, Zhong Q, Gu X, Liu J, Huang L, Xie R, Li X, Xu Y, Luo Z, Liao M, Wang H, Sun L, Li H, Lau GW, Duan C. 2016. Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014. Eur J Clin Microbiol Infect Dis 35(2):269-77.
    52. McDaniel C, Panmanee W, Su S, Kapoor R, Cox K, Paul AT, Lau GW, Ko S-H, Mortensen J, Lam JS, Muruve DA, Hassett DJ. 2016. A putative ABC transporter permease is necessary for resistance to acidified nitrite and EDTA in Pseudomonas aeruginosa under aerobic, anaerobic, planktonic or biofilm conditions. Frontiers Microbiol 7:291.
    53. Zhang L, Li Y, Wen Y, Lau GW, Huang X, Wu R, Yan Q, Huang Y, Zhao Q, Ma X, Wen X, Cao S. 2016. HtrA is important for stress resistance and virulence in Haemophilus parasuis. Infect Immun 84(8):2209-19.
    54. Li Y, Cao S, Zhang L, Yuan J, Lau GW, Wen Y, Wu R, Zhao Q, Huang X, Yan Q, Huang Y, Wen X. 2016. Absence of TolC impairs biofilm formation in Actinobacillus pleuropneumoniae by reducing initial attachment. PLoS ONE 11(9):e0163364.
    55. Li Y, Cao S, Zhang L, Lau GW, Wen Y, Wu R, Zhao Q, Huang X, Huang Y, Yan Q, Wen X. 2016. One of two TolC-like proteins is involved in antibiotic resistance and biofilm formation of Actinobacillus pleuropneumoniae clinical isolate SC1516. Frontiers Microbiol 7:1618.
    56. Kuang Z, Hao Y, Zhu L, Akinbi HT, Hassett DJ, Lau GW. 2017. Remodeling of Pseudomonas aeruginosa quorum-sensing during acute pneumonia by recognition of surfactant phospholipids. PLoS Pathog, in revision.
    57. Choi WS, Choi S, Lin JJ, Mathew A, VY Li, Lau GW. 2017. Exenatide restores mucus homeostasis in chronically-diseased airways through GLP1R-PPARg-FOXA2-phosphatase signaling. Submitted to J Clin Invest. 09/2017.