Publications

 

2017

Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiological Reviews. 2017 Jul 1;97(3):995-1043. (PMID:28539434)


Baumgarten SC, Armouti M, Ko C, Stocco C. IGF1R Expression in Ovarian Granulosa Cells is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice. Endocrinology. 2017 Apr 12.(PMID:28407051)

Cacioppo JA, Lin PP, Hannon PR, McDougle DR, Gal A, Ko C. Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture. Scientific reports. 2017 Apr;7(1):817-. (PMID:28400616)

Lan ZJ, Krause MS, Redding SD, Li X, Wu GZ, Zhou HX, Bohler HC, Ko C, Cooney AJ, Zhou J, Lei ZM. Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice. Molecular and Cellular Endocrinology. 2017 Mar 15;444:26-37. (PMID: 28137614)

Barakat R, Lin PC, Rattan S, Brehm E, Canisso IF, Abosalum ME, Flaws JA, Hess R, Ko C. Prenatal exposure to DEHP induces premature reproductive senescence in male mice. Toxicological Sciences. 2017 Jan 12:kfw248. (PMID: 28082598)

 

2016

Min E, Kandel ME, Ko CJ, Popescu G, Jung W, Best-Popescu C. Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy. Scientific Reports. 2016;6. (PMID: 28009019)

Ma Y, Andrisse S, Chen Y, Childress S, Xue P, Wang Z, Jones D, Ko C, Divall S, Wu S. Androgen Receptor in the Ovary Theca Cells Plays a Critical Role in Androgen-Induced Reproductive Dysfunction. Endocrinology. 2017 Jan 1;158(1):98-108.(PMID: 27841936)

Han KA, Shin WH, Jung S, Seol W, Seo H, Ko C, Chung KC. Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation. Human molecular genetics. 2017 Jan 1;26(1):1-8.(PMID: 27798112)

Oakley OR, Kim KJ, Lin PC, Barakat R, Cacioppo JA, Li Z, Whitaker A, Chung KC, Mei W, Ko C. Estradiol synthesis in gut-associated lymphoid tissue: leukocyte regulation by a sexually monomorphic system. Endocrinology. 2016 Oct 25;157(12):4579-87.(PMID: 27779914)

Barakat R, Oakley O, Kim H, Jin J, Ko CJ. Extra-gonadal sites of estrogen biosynthesis and function. BMB reports. 2016 Sep 30;49(9):488. (PMID: 27530684)

Gal A, Lin PC, Cacioppo JA, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, Ko C. Loss of fertility in the absence of progesterone receptor expression in kisspeptin neurons of female mice. PLoS One. 2016 Jul 21;11(7):e0159534.(PMID: 27441639)

Cerny KL, Ribeiro RA, Jeoung M, Ko C, Bridges PJ. Estrogen receptor alpha (ESR1)-dependent regulation of the mouse oviductal transcriptome. PloS one. 2016 Jan 25;11(1):e0147685.(PMID : 26808832)

Joseph A. Cacioppo, Yongbum Koo, Po-Ching Patrick Lin, Sarah A. Osmulski, Chunjoo D. Ko, CheMyong Ko. Generation of an estrogen receptor beta-iCre knock-in mouse. Genesis 54.1 (2016): 38-52. (PMID: 26663382)

Amanda L. Mereness, Zachary C. Murphy, Andrew C. Forrestel, Susan Butler, CheMyong Ko, JoAnne S. Richards, and Michael T. Sellix. Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice. Endocrinology 157.2 (2016): 913-927. (PMID: 26671182)

 

2015

Joseph Cacioppo, Yongbum Koo, Arnon Gal and CheMyong Ko. Generation and characterization of an Endothelin-2 iCre mouse. Genesis. 53.2 (2015): 245-256.(PMID: 25604013)

Yuechao Zhao, Ping Gong, Yiru Chen, Jerome C. Nwachukwu, Sathish Srinivasan, CheMyong Ko, Milan K. Bagchi, Robert N. Taylor, Kenneth S. Korach, Kendall W. Nettles, John A. Katzenellenbogen and Benita S. Katzenellenbogen. Dual Suppression of Estrogenic and Inflammatory Activities for Targeting of Endometriosis. Science Transl Med. 7(271):271ra9, 2015. DOI: 10.1126/scitranslmed. 3010626

 

2014

Thomas Gawriluk, CheMyong Ko, Xiaoman Hong, Lane Christenson, Edmund Rucker III. Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor. PNAS 111(40): E4194-203. (PMID: 25246579)

Eunsook Park, Chin-Hee Song, Jae-Il Park, Ryun-Sup Ahn, Hueng-Sik Choi, CheMyong Ko, Keesook Lee. Transforming Growth Factor-β1 Signaling Represses Testicular Steroidogenesis through Cross-Talk with Orphan Nuclear Receptor Nur77. Plos One 9(8):e104812 (PMID: 25140527).

Novaira HJ, Sonko ML, Hoffman G, Koo Y, CheMyong Ko, Wolfe A, Radovick S. Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Molecular Endocrinology 28(2):225-238 (PMID: 24422632).

Joseph Cacioppo, Sang-Wook Oh, Hey-young Kim, Jongki Cho, Po-Ching Lin, Masashi Yanagisawa and CheMyong Ko. Loss of Function of Endothelin-2 leads to Reduced Ovulation and CL Formation. Plos One 24;9(4);e96115 (PMID:24763822).

Arnon Gal, Po-Ching Lin, Anne Barger, Amy MacNeill, CheMyong Ko. Vaginal fold histology reduces the variability introduced by vaginal exfoliative cytology in the classification of mouse estrous cycle stages. In press. (PMID:24705880).

Sheng Wu, Sara DiVall, Amanda Nwaopara, Sally Radovick, Fredric Wondisford, CheMyong Ko, Andrew Wolfe. Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes 63(4):1270-82 (PMID: 24379345).

 

2013

Giyoun Na, Andrew Wolfe, CheMyong Ko, Hyesook Youn, Young-Min Lee, Sung June Byun, Iksoo Jeon and Youngbum Koo. A low-copy-number plasmid for retrieval of Toxic Genes from BACs and Generation of Conditional Targeting Constructs. Mol Biotechnol. 54(2):504-14 (PMID: 22945876)

Sanz E, Evanoff R, Quintana A, Evans E, Miller JA, CheMyong Ko, Amieux PS, Griswold MD, McKnight GS. RiboTag Analysis of Actively Translated mRNAs in Sertoli and Leydig Cells In Vivo. PLoS One. 2013 Jun 11;8(6):e66179 (PMID: 23776628)

 

2012

CheMyong Ko*, Rina Meidan and Phillip Bridges. Why two endothelins and two receptors for ovulation and luteal regulation? Life Sci. 91:501-6 (PMID: 22677434)

Seung-Yon Lee, Eunsook Park, Seung-Chang Kim, Ryun-Sup Ahn, CheMyong Ko, Keesook Lee. ERa/E2 signaling suppresses the expression of steroidogenic enzyme genes via cross-talk with orphan nuclear receptor Nur77 in the testes. Mol Cell Endocrinol. 362 (1-2):91-103 (PMCID: 22683664)

José E. Sánchez-Criado, Kourtney Trudgen, Yolanda Millán, Alfonso Blanco, José C. Garrido-Gracia, Rafaela Aguilar, José Monterde, Juana Martín de las Mulas and CheMyong Ko. Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific ESR1 knockout female mice. Reproduction 143(4):549-58. (PMID: 22367588)

Jongki Cho, Heyyoung Kim, Dong-Wook Kang, Masashi Yanagisawa and CheMyong Ko*. Endothelin B receptor is not required but necessary for finite regulation of ovulation. Life Sci. 91(13-14): 613-7. (PMID: 22406076).

Phillip J. Bridges, Myoungkun Jeoung, Sarah Shim, Ji Yeon Park, Jae Eun Lee, Lindsay A. Sapsford, Kourtney Trudgen, CheMyong Ko, Myung Chan Gye and Misung Jo. Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase. Endocrinology 153(4): 1925-35 (PMID 22374975).

 

2011

Hyunjoon, Kim, Mary C Gieske, Kourtney Trudgen, Beobgyun Kim, Jaewook Jeoung, Susan Hudgins-Spivey, Andree Krust, Pierre Chambon and CheMyong Ko*. Identification of estradiol/ERa-regulated genes in the pituitary. Journal of Endocrinology 210(3):309-21 (PMID: 21700660).

Tae-Hwa Baek, Joo-Heon Kim, Mee-Ja Park, Hye-Kyung Lee, Hyun-Jin Son, Hyun-Ki Soon, Chang-Nam Kim, CheMyong Ko and Dong Wook Kang. Stromal overexpression of decay accelerating factor (Daf/CD55) correlates with poor clinical outcome in colorectal cancer patients. The Korean Journal of Pathology 45:445-454.

Oliver Oakley, Po-Ching Lin, Phillip Bridges and CheMyong Ko*. Animal models for the study of polycystic ovarian syndrome (PCOS). Endocrinology and Metabolism 26(3):193-202.

Oliver Oakley, Michele Frazer and CheMyong Ko*. Pituitary-ovarian-splenic axis in ovulation. Trends in Endocrinology & Metabolism (TEM) 22(9): 345-52 (PMID: 21600783). Invited review

Dong-Hee Choi, Eun Kyung Kim, Kyeoung-Hwa Kim, Kyung-Ah Lee, Hey Young Kim, Phillip Bridges, and CheMyong Ko*. Human ovarian endothelin system.  Human Reproduction. 26 (5): 1171-1180. (PMID: 21406445)

Phillip J Bridges, Jongki Cho and CheMyong Ko*. Endothelins in regulating ovarian and oviductal function. Frontier in Bioscience S3. 145-155 (PMID: 21196365). Invited review

Phillip Bridges, Myoungkun Jeoung, Heyyoun Kim, Jung Ho Kim, Dongryul Lee, CheMyong Ko* and Doris Baker. Methodology matters:  In-Vitro fertilization versus intracytoplasmic sperm injection and embryonic gene expression.  Reproductive Biomedicine Online 23(2): 234-44 (PMID: 21665548)

Mohamed Bani-Ahmad, Ismail El-Amouri, CheMyong Ko, Feng Lin, Yajarayma Tang-Feldman and Oliver Oakley. The role of decay accelerating factor in the immunopathogenesis of  cytomegalovirus infection. Clinical and Experimental Immunology. (PMID: 21166665)

Soichi Yamashita, Ping Tai, Jean Charron, CheMyong Ko, and Mario Ascoli. The MEK/ERK pathway is essential for maintaining a functional population of adult Leydig cells and for male fertility. Molecular Endocrinology. (PMID: 21527500)

M. J. Kim, H. J. Oh, J. E. Park, J. E. Kim, S. G. Hong, G. Jang, M. S. Kwon, B. C. Koo, T. A. Kim, S. K. Kang, CheMyong Ko, and B. C. Lee. Generation of transgenic dogs that conditionally express green fluorescent protein. Genesis. 49:472–478 (PMID: 21630415)

 

2010

Oliver R. Oakley, HeyYoung Kim, Ismail El-Amouri, Po-Ching Patrick Lin, Jongki Cho, Mohammad Bani-Ahmad, CheMyong Ko*. Preovulatory leukocyte infiltration in the rat ovary. Endocrinology 151(9): 4551-9. (PMID: 20591976)

Phillip J. Bridges, Misung Jo, Linah Al-Alem, Giyoun Na, Wen Su, Ming C. Gong, Myoungkun Jeoung and CheMyong Ko*. Production and binding of endothelin-2 (EDN2) in the rat ovary: Endothelin receptor subtype A (EDNRA) mediated contraction. Reproduction, Fertility and Development 22: 780-787 (PMID: 20450830)

Ismail El-Amouri, Mohamad Ahmad, Yajarayma Tang-Feldman, Feng Lin, CheMyong Ko, Claire Pomeroy, Oliver Oakley. Increased morbidity & mortality in MCMV infected mice following allogeneic bone marrow transplant is associated with reduced surface DAF expression. Clinical and Experimental Immunology 126: 379-391. (PMID: 20840652)

Myoungkun Jeoung, Sungeun Lee, Hee-kyung Hawng, Yong-Pil Cheon, Youn Kyung Jeong, Myung Chan Gye, Marc Iglarz, CheMyong Ko and Phillip J. Bridges. Identification of a novel role for endothelins within the oviduct. Endocrinology 151(6):2858-67. (PMID: 20357223)

Mohamed Bani-Ahmad, Ismail El-Amouri, CheMyong Ko, Feng Lin, Yajarayma Tang-Feldman and Oliver Oakley. The role of decay accelerating factor in the immunopathogenesis of cytomegalovirus infection. Clinical and Experimental Immunology. 163: 199–206 (PMID: 21166665)

Avenel Joseph, Barry D. Shur, CheMyong Ko, Pierre Chambon, and Rex Hess. Epididymal hypo-osmolality induces abnormal sperm morphology and function in the estrogen receptor alpha knockout mouse. Biol Reprod.  82(5): 958-67. (PMID: 20130266)

Avenel Joseph, Rex Hess, David J. Schaeffer, CheMyong Ko, Susan Hudgins-Spivey, Pierre Chambon, Barry D. Shur. Absence of Estrogen Receptor Alpha Leads to Physiological Alterations in the Mouse Epididymis and Consequent Defects in Sperm Function. Biol Reprod. 82(5): 948-57. (PMID: 20130267)

Dong-Wook Kang, Chun-Hwa Ihm, Jong-Ho Baek, Mee-Young Park, Joo-Heon Kim, Hyun Jin Son, Hye-Kyung Lee, Mee-Ja Park, CheMyong Ko. Histo-Physiologic Characteristics of Oocyte-Specific ERα Knockout Mouse Ovary. Bumsuk Journal, vol 13, 13-23.

Dong Wook Kang, Hyun Jin Son, Joo Heon Kim, Hye Kyung Lee, Mee Ja Park, CheMyong Ko. Pathologic Characteristics of Ovarian Hemorrhagic Polycyst in Estrogen Receptor-alpha (ERα) Knockout Mice and Roles of ERα in Hemorrhagic Polycyst. The Korean Journal of Pathology 44:376-83.

 

2009

Sungeun Lee, Dong-Wook Kang, Susan Hudgins-Spivey, Andree Krust, Eun-Young Lee, Youngbum Koo, Yongpil Cheon, Myung Chan Gye, Pierre Chambon and CheMyong Ko*. Theca-specific Esr1 knockout mice lose fertility prematurely. Endocrinoloy 150(8):3855-62.

So Gun Hong, Min Kyu Kim, Goo Jang, Hyun Ju Oh, Jung Eun Park, Jung Taek Kang, Ok Jae Koo, Teoan Kim, Mo Sun Kwon, Bon Chul Koo, Jeong Chan Ra, Dae Yong Kim, CheMyong Ko and Byeong Chun Lee.  Generation of RFP Transgenic Dogs.  Genesis. 47(5):314-22.

Beob Gyun Kim, Merlin Lindeman, Phillip Bridges, CheMyong Ko*. Gene Expression Profiler for DNA microarray Data. Rev Colomb Cienc Pecu 22:12-18.

 

2008

Phillip J. Bridges, Yongbum Koo, Dong-Wook Kang, Susan Hudgins-Spivey, Zi-Jian Lan, Xueping Xu, Francesco DeMayo, Austin Cooney and CheMyong Ko*. Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis. Genesis 46: 499-505.

Giyoun Na, Phillip J. Bridges, Yongbum Koo, and CheMyong Ko*. Role of hypoxia in the regulation of periovulatory endothelin-2 (EDN2) expression in the mouse. Canadian Journal of Physiology and Pharmacology (CJPP). 86(6):310-319 (Invited manuscript for a special edition for endothelins).

Mary C. Gieske, Hyun Joon Kim, Sandra Legan, Youngbum Koo, Andree Krust, Pierre Chambon, and CheMyong Ko*. Pituitary gonadotroph estrogen receptor-alpha is necessary for fertility in females. Endocrinology 149(1): 20-27.


CheMyong Ko*, Susan Hudgins-Spivey, Sungeun Lee, Phillip Bridges, and Mary C. Gieske. Estrogen in female reproductive axis: Positive estrogen feedback to pituitary. Kor. J of Reproductive Medicine. 34(4):1-11.


 

2007

Hyun Joon Kim, Mary C. Gieske, Susan Hudgins, Beob Gyun Kim, Andree Krust, Pierre Chambon, and CheMyong Ko*. Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary. Journal of Endocrinology 195:393-405.

Linah Al-Alem, Phillip Bridges,  Mary C. Gieske, Wen Su, Ming C Gong, Marc Iglarz and CheMyong Ko*. Endothelin-2 in oocyte transport in the oviduct. Journal of Endocrinology 193(3): 383-391.

 

2006

CheMyong Ko*, Mary C. Gieske, Linah Al-Alem, YunKyung Hahn, Wen Su, Ming C. Gong, Yongbum Koo  and Marc Iglarz. Endothelin-2 in Ovarian Follicle Rupture. Endocrinology 147(4):1770-1779.

 

2005

Gieske MC, Na G, Jo M, Koo K, Curry TE Jr., CheMyong Ko*. Decay-Accelerating Factor DAF in the Periovulatory Rat Ovary.  Journal of Endocrinology 186: 303-313.

Mary C. Gieske, Charles E. Payne, Joseph B. Gieske, and CheMyong Ko*. rOGED: NAR  Molecular Biology Database Collection entry number 739. Nucl. Acids Res. 33: D5-D24.

 

2004

Misung Jo, Mary C. Gieske, Charles E. Payne, Joseph B. Gieske, Ignatius Vijai,  Sarah E. Wheeler, Thomas E. Curry Jr, CheMyong Ko*. Development and application of a rat ovarian gene expression database (rOGED). Endocrinology 145(11):5384-5396.

 

2003

CheMyong Ko, Grieshaber A, Ji I, Ji TH. Follicle-stimulating hormone suppresses cytosolic 3,5,3'-triiodothyronine-binding protein messenger ribonucleic acid expression in rat granulosa cells. Endocrinology 144 :2360-2367.

CheMyong Ko* and Hae-Moon Chung. Xenopus hoxc8 during early development. Biochem. Biophys. Res. Commun. 12: 300(1): 9-15.

Nicole A. Grieshaber, CheMyong Ko, Scott S. Grieshaber, Inhae Ji and Tae H. Ji. FSH-Responsive cytoskeletal genes in rat granulosa cells; class I beta-tubulin, tropomyosin-4 and kinesin heavy chain.  Endocrinology 144(1): 29-39.

 

2001

Inho Choi, CheMyong Ko, Ok-Kyong Park-Sarge, Quing Zhou, Rex Hess, Charles Graves and Benita S Katzenellenbogen.  Human estrogen receptor beta-specific antibodies: Characterization and use in studies of estrogen receptor beta protein expression in reproductive tissues.  Mol Cell Endocrinol. 181(1-2):139-150.

 

~2000

2000, CheMyong Ko and Ok-Kyong Park-Sarge.  Progesterone receptor activation mediates LH-induced type-I pituitary adenylate cyclase-activating polypeptide receptor (PAC1) gene expression in rat granulosa cells. Biochem Biophys Res Commun.  277:270-279.

2000, Katherine M Graham, CheMyong Ko, KyongSoo Park, Kevin Sarge and Ok-Kyong Park-Sarge.  Expression of an intracisternal A-particle-like element in rat ovary. Biochem Biophys Res Commun. 278(1):48-57.

1999, CheMyong Ko, Yongho In and Ok-Kyung Park-Sarge. Role of progesterone receptor activation in pituitary adenylate cyclase activating polypeptide gene expression in rat ovary. Endocrinology 140(11): 5185-5194.

1997, CheMyong Ko and Hae-Moon Chung. Spatio-temporal pattern formation of adominal muscle in Xenopus laevis. Korean J. of Bio. Sciences 1: 329-335.

1997, Hyun-hee Kim, CheMyong Ko, Hae-Moon Chung, Wonsun Kim and Sanguk Nahm. Partial cloning and analysis of fibroblast growth factor like cDNA, which is expressed in Xenopus laevis oocytes. Korean J. of Genetics 18: 51-54.

1996, Tae-Kyun Kim, CheMyong Ko, Sanguk Nahm and Hae-Moon Chung. Partial cloning of Xhoxc3.1 gene in Xenopus laevis. Korean J. of Genetics 18: 111-116.