Progesterone receptor in regulating follicle rupture

Luteinizing hormone (LH) is secreted from the pituitary and triggers ovulation. Progesterone is synthesized in the ovary upon stimulated by LH, and activates progesterone receptor (PGR) leading to ovulation. I hypothesize that PGR activation stimulates cytokine productions in the ovary, which in turn recruits leukocyte into the ovary causing ovulatory inflammation. I will identify PGR-regulated cytokines and determine their role in recruiting leukocytes.  For this purpose, I will utilize molecular biological tools and genetically modified animal models.