Jodi A. Flaws
Professor, Veterinary Biosciences
Professional Interests: The main
focus of my laboratory is to determine the genetic and environmental
factors that affect the female reproductive system. Specifically,
the research in my laboratory is designed to address the following major
questions: (1) Which genes and hormones regulate the normal development
and function of the ovary? (2) What are the effects of environmental
toxicants on the development and function of the ovary? (3) What are
the mechanisms that underlie the effects of reproductive toxicants on
the ovary? (4) Are environmental exposures associated with reproductive
abnormalities in women?
Selected Publications:
Khachik F, London E, de Moura F, Johnson M, Steidl S, Detolla L, Shipley S, Sanchez B, Chen X, Flaws J, Lutty G, McLeod S, Fowler B. (2006) Chronic ingestion of (3R,3'R,6'R)-lutein and (3R,3'R)-emaciating in female rhesus macaque. Investigative Ophthalmology and Visual Sciences (in press).
Tonic D, French MS, Babes JK, Synods D, Fourth PA , Ko os RD , Flaws JA. (2006) Effects of ER a over expression on female reproduction in mice. Reproductive Toxicology (in press) .
Whitcomb B, Whiteman MK, Langenberg P, Flaws JA, Romani WA. (2006) Physical activity and risk of hot flashes among women in midlife. Journal of Women's Health (in press).
Gupta RK, Schuh RA, Fiskum G, Flaws JA. (2006) Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicology and Applied Pharmacology (in press).
Gupta RK, Schuh RA, Fiskum G, Flaws JA. (2006) Methoxychlor causes mitochondrial dysfunction and oxidative damage in the mouse ovary. Toxicology and Applied Pharmacology (in press).
Gupta RK, Miller KP, Babus JK, Flaws JA. (2006) Methocychlor inhibits atresia of antral follicles through an oxidative stress pathway. Toxicological Sciences (in press).
Tomic D, Frech MS, Babus JK, Gupta RK, Furth PA, Koos RD, Flaws JA. (2006) Methoxychlor induces atresia of antral follicles in ER a over-expressing mice. Toxicological Sciences 93:196-204 .
Miller KP, Gupta RK, Flaws JA. (2006) Methoxychlor metabolites may cause ovarian toxicity through estrogen regulated pathways. Toxicological Sciences 93:180-188 .
Barnett KR, Schilling C, Greenfeld CR, Tomic D, Flaws JA. (2006) Ovarian follicle development and transgenic mouse models. Human Reproduction Update 12:537-555.
Bankowski B, Gallicchio, LM, Whiteman MK, Lewis LM, Zacur HA, Flaws JA. (2006) The association between menopausal symptoms and quality of life in midlife women. Submitted to Fertility and Sterility (in press).
Flaws JA, Marion SL, Miller KP, Christian, PJ, Babus JK, Hoyer PB. (2006) Effect of bcl-2 over expression in mice on ovotoxicity caused by 4-vinylcyclohexene. Toxicology and Applied Pharmacology 215:51-56 .
Miller SR, Gallicchio L, Lewis LM, Babus JK, Langenberg P, Zacur H, Flaws JA. (2006) Association between race and hot flashes in midlife women. Maturitas 54:260-269.
Gallicchio L, Whiteman MK, Tomic D, Miller KP, Langenberg P, Flaws JA. (2006) Type of menopause, patterns of hormone therapy use, and hot flashes. Fertility and Sterility 85:1432-1440.
