Trainee Publications

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Janice Bahr

Janssen, S, Dalponte, M., Lee, K.H., Boltz, D., Nakai, M., Bunick D., and Bahr, J.M. (2006) Ion transporters for fluid reabsorption in the rooster epididymal region: Detection of mRNAs and proteins of Na+, K+-ATPase, carbonic anhydrase II and sodium hydrogen exchanger-3. Animal Reprod Sci 95:331-337.

Bahr, J.M., Nakai, M., Rivera, A., Walsh, J., Evans, G.L., Lotinun, S., Turner, R.T., Black, M., Jeffery, E.H. (2004) Dietary soy protein and isoflavones: Minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Menopause 12:165-173.

Paul S. Cooke
Cooke P.S., Holsberger D., Cimafranca M.A., Meling D., Beals C., Nakayama K., Nakayama K., Kiyokawa H. (2007) The F box protein Skp2 regulates adipose mass and adipocyte number in vivo. Obesity 15:1400-1408.

Cooke P.S., Gore A.C., Crews D., Simon L, Cimafranca M.A., (2008) Environmental Endocrine Disruptors and Male Reproductive Toxicology. In: Comprehensive Toxicology, 2nd edition, Volume 11, P. Hoyer and J. Richburg (eds.), Elsevier Press, Oxford, England (in press).
Jodi Flaws
Hernández-Ochoa, I., Karman, B.N. and Flaws, J.A. The role of the aryl hydrocarbon receptor in the female reproductive system. Special issue: Biological functions of the aryl hydrocarbon receptor. Biochem Pharmacol 2008 in press.
William Helferich
Ju, Y.H., Doerge, and Helferich, W.G. (2008). A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food Chem. Toxicology. 46, 1, 310-320.

Wang V.C., Sable H.J., Ju Y.H., Allred C.D., Helferich W.G., Korol D.L., Schantz S.L. (2008). Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behav Neurosci. 2008 Aug;122(4):794-804.

Helferich W.G., Andrade J.E., Hoagland M.S. (2008). Phytoestrogens and breast cancer: a complex story. Inflammopharmacology. 2008 Sep 26. [Epub ahead of print] PMID: 18815740.

Ju, Y.H., Doerge, D.R., Hartman, J.A., Kwak, J., and Helferich, W.G.. (2008) Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) implanted in ovariectomized athymic mice. Carcinogenesis. Advance Access published on July 16, 2008; doi: doi:10.1093/carcin/bgn161.

Wu R, Zhang L, Hoagland M.S., and Swanson H. (2007) “Lack of the AhR leads to impaired activation of AKT/PKB and enhanced sensitivity to apoptosis induced via the intrinsic pathway.” J Pharmacol Exp Ther. In Press.

Ju, Y.H., Allred, K.F., Allred, C.D., and Helferich, W.G., (2006) Genistein Stimulates Growth of Human Breast Cancer Cells in a Novel, Postmenopausal Animal Model, with Low Plasma Estradiol Concentrations. Carcinogenesis Jun 27(6):1292-9.

Putt K.S., Chen G.W., Pearson J.M., Sandhorst J.S., Hoagland M.S., Kwon J.T., Hwang S.K., Jin H, Churchwell M.I., Cho M.H., Doerge D.R., Helferich W.G., Hergenrother P.J. (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2(10):543-50.

Ju, Y.H., Fultz, M.J., Allred, K.F., Doerge, D.R., and Helferich, W.G., (2006) Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumor implanted in ovariectomized athymic mice. Carcinogenesis 27(4):856-63.

Allred, C.D., Twaddle, N.C., Allred, K.F., Churchwell, M.I., Ju, Y.H., Helferich, W.G., and Doerge, D. R. (2005) Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized Balb/c mice. J. Agric. Food Chem. 53(22):8542-8550.

Allred, C.D., Twaddle, N.C., Allred, K.F., Churchwell, M.I., Ju, Y.H., Helferich, W.G., and Doerge, D.R. (2004) Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized Balb/c mice. Journal of Nutrition.

Selvaraj, V., Zakroczymski, M.A., Naaz, A, Mukai, M, Ju, Y.H., Doerge, D.R., Katzenellenbogen, J.A., Helferich, W.G., and Cooke, P.S. (2004) Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice. Biology of Reproduction 71:966-972.

Allred, C.A., Allred, K.F., Ju, Y.H., Doerge, D.R., and Helferich, W.G. (2004) Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25:1649-1657.

Ju, Y.H., Clausen, L.M., Almada, A.L., and Helferich, W.G., (2004) beta-Sitosterol, beta-sitosterol glucoside, and a mixture of beta-sitosterol and beta-sitosterol glucoside modulate the growth of estrogen-responsive breast cancer cells in vitro and in ovariectomized athymic mice. Journal of Nutrition 134(5):1145-1151.

Muthyala, R.S., Ju, Y.H., Sheng, S., Williams, L.D., Doerge, D.R., Helferich, W.G., and Katzenellenbogen, J.A. (2004) Equol, a natural estrogenic metabolite from soy isoflavones: Convenient synthesis and resolution of R- and S-equol and their biological activity through the estrogen receptors alpha and beta. Bioorganic and Medicinal Chemistry 12(6):1559-1567.

Allred, C.A., Allred, K. F., Ju, Y.H., Doerge, D.R., Schantz, S., Korol, D., and Helferich, W.G. (2004) Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats. Carcinogenesis 25(2):211-218.

Ju, Y.H., Doerge, D.R., Allred, K.F., Allred, C.D., and Helferich, W.G. (2002) Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Research 62:2474-2477.
Rex A. Hess
Morrow, C.M.K., Park, S.E., Mukai, M., Katzenellenbogen, B.S., Hess, R.A. 2006. Reproductive abnormalities in repressor of estrogen receptor activity (REA) heterozygous knockout mice. J Androl: 39-39 11 Suppl.

Gist, D.H., Bradshaw, S., Morrow, C.M.K., Congdon, J.D., Hess, R.A. 2006. Estrogen response system in the reproductive tract of the male turtle: An immunocytochemical study. Gen Comp Endocrinol 151(1):27-33.

Tomaszewski, J., Joseph, A., Archambeault, D. and Yao, H.H.. 2007. Essential roles of inhibin beta a in mouse epididymal coiling. Proc Natl Acad Sci U S A 104(27): 11322-11327.

Gist, D.H., Bradshaw, S., Morrow, C.M.K., Congdon, J.D., Hess RA. 2007. Estrogen response system in the reproductive tract of the male turtle: An immunocytochemical study. Gen Comp Endocrinol. 151(1): 27-33.

Morrow, C.M.K., Hostetler, C., Griswold, M., Hofmann, M.C., Murphy, K., Cooke, P.S., Hess, R.A. 2007. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood-testes barrier function and testicular immune privilege. Ann N Y Acad Sci. Oct 2 [Epub]

Morrow C.M., Hostetler C.E., Griswold M.D., Hofmann M.C., Murphy K.M., Cooke P.S. and Hess R.A. (2007). "ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege." Ann N Y Acad Sci 1120: 144-51.

Tomaszewski J., Joseph A., Archambeault D. and Yao H.H. (2007). "Essential roles of inhibin beta A in mouse epididymal coiling." Proc Natl Acad Sci U S A 104(27): 11322-7.
Benita Katzenellenbogen
Barnett, D. H., Sheng, S., Charn, T. H., Waheed, A., Sly, W. S., Lin, C. Y., Liu, E. T., Katzenellenbogen, B. S. Estrogen receptor regulation of Carbonic Anhydrase XII through a distal enhancer in breast cancer. Cancer Research, 68:3505-15, 2008. PMID: 18451179

Sheng, S., Barnett, D. H., Katzenellenbogen, B. S. Differential estradiol and selective estrogen receptor modulator (SERM) regulation of keratin 13 gene expression and its underlying mechanism in breast cancer cells. Mol. Cell Endocrinol., in press, 2008. doi: 10.1016/j.mce.2008.09.022 PMID: 18951949

Chang, E.C., Charn, T. H., Park, S. H., Helferich, W. G., Komm, B., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Estrogen receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol. Endocrinol., 22:1032-43, 2008. PMID: 18258689

Stossi, F., Madak-Erdogan, Z., Katzenellenbogen, B. S. Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1. Submitted, 2008.

Madak-Erdogan, Z., Kieser, K. J., Kim, S. H., Komm, B., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol. Endocrinol., 22:2116-2127, 2008. PMID: 18617595

Lin, C. Y., Vega, V. B., Thomsen, J. S., Zhang, T., Kong, S. L., Xie, M., Chiu, K. P., Lipovich, L., Barnett, D. H., Stossi, F., George, J., Kuznetsov, V. A., Lee, Y. K., Charn, T. H., Palanisamy, N., Miller, L. D., Katzenellenbogen, B. S., Ruan, Y., Bourque, G., Wei, C., Liu, E. T. Whole-genome cartography of estrogen receptor-alpha binding sites. PLoS Genetics, 3:e87, 2007. PMID: 17542648

Frasor, J., Chang, E. C., Komm, B., Lin, C. Y., Vega, V. B., Liu, E. T., Miller, L. D., Smeds, J., Bergh, J. and Katzenellenbogen, B. S. (2006) Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Research, 66:7334-7340.

Chang, E. C., Frasor, J., Komm, B. and Katzenellenbogen, B. S. (2006) Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology, 147:4831-4842.

Harrington, W. R., Kim, S. H., Funk, C. C., Madak-Erdogan, Z., Schiff, R., Katzenellenbogen, J. A. and Katzenellenbogen, B. S. (2006) Estrogen dendrimer conjugates that preferentially activate extranuclear, non-genomic versus genomic pathways of estrogen action. Mol. Endocrinol., 20: 491-502.

Frasor, J., Danes, J. M., Funk, C. C. and Katzenellenbogen B.S. (2005) Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc. Natl. Acad. Sci. USA, 102:13153-13157.

Frasor, J., Danes, J.M., Funk, C.C., and Katzenellenbogen B.S. (2005) Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc. Natl. Acad. Sci. USA, 102:13153–7.

Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R. and Katzenellenbogen, B.S. (2004) Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor alpha or estrogen receptor beta in human osteosarcoma cells: Distinct and common target genes for these receptors. Endocrinology, 145:3473-3486.

Harrington, W. R., Sheng, S., Barnett, D. H., Petz, L., Katzenellenbogen, J. A., and Katzenellenbogen, B. S. (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Molecular and Cellular Endocrinology 206:13-22.

Rajendran, R.R., Nye, A.C., Frasor, J., Balsara, R.D., Martini, P.G., and Katzenellenbogen, B.S. (2003) Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97). J. Biol. Chem. 278: 4628-4638.
John Katzenellenbogen
V. S. Likhite, F. Stossi F, K. Kim, B. S. Katzenellenbogen, J. A. Katzenellenbogen. (2006) Kinase-Specific Phosphorylation of the Estrogen Receptor Changes Receptor Interactions with Ligand, DNA, and Coregulators Associated with Alterations in Estrogen and Tamoxifen Activity. Mol Endocrinol. 20:3120-3132.

F. Stossi, V. S. Likhite, J. A. Katzenellenbogen, B. S. Katzenellenbogen. (2006) Estrogen-Occupied Receptor Represses Cyclin G2 Gene Expression and Recruits a Repressor Complex at the Cyclin G2 Promoter. J. Biol. Chem. 281, 16272-16278.

Likhite, V.S., Kass, E.I., Anderson, S.D., Yates, J.R., Nardulli, A.M. (2004). Interaction of estrogen receptor á with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. Journal of Biological Chemistry, 279:16875-16882.
Ann Nardulli
Loven, M.A., Davis, R.E., Muster, N., Yates, J.R., Nardulli, A.M. (2004) A novel estrogen receptor a-associated protein alters receptor-DNA interactions and represses receptor-mediated transcription. Mol Endocrinol 18:2649-2659.

Schultz, J.R., Petz, L.N., Nardulli, A.M. Cell-and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors a and b. Journal of Biological Chemistry 280:347-354.

Petz, L.N., Ziegler, Y.S., Schultz, J.R., Kim, H., Kemper, J.K., Nardulli, A.M. Differential regulation of the human progesterone receptor gene by an estrogen response element half site and Sp1 sites. Journal of Steroid Biochemical and Molecular Biology 88(2):113-22.

Petz, L.N., Ziegler, Y.S., Nardulli, A.M. (2003) Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. Molecular Endocrinology 18:521-532.

Harrington, W.R., Sheng, S., Barnett, D.H., Petz, L.N., Katzenellenbogen, J.A., Katzenellenbogen, B.S. (2003) Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Molecular Cellular Endocrinology 206:13-22.

Schultz, J.R., Petz, L.N., Nardulli, A.M. (2003) Estrogen receptor alpha and Sp1 regulate progesterone receptor gene expression. Molecular Cellular Endocrinology 201:165-175.

Loven, M.A., Muster, N., Yates, J.R., Nardulli, A.M. (2003) A novel estrogen receptor alpha associated protein, template activating factor I beta, inhibits acetylation and transactivation. Molecular Endocrinology 17:67-78.

Petz, L.N., Ziegler, Y.S., Loven, M.A., Nardulli, A.M. (2002) Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the human progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology: 143:4583-4591.

Min, G., Kim, H., Bae, Y., Petz, L., Kemper, J.K. (2002) Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. Journal of Biological Chemistry 277:34626-34633.

Petz, L.N., Ziegler, Y.S., Loven, M.A., Nardulli, A.M. (2002) Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the human progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology 143:4583-4591.

Schultz, J.R., Loven, M.A., Senkus Melvin, V.M., Edwards, D.P., Nardulli A.M. (2002) Differential modulation of DNA conformation by estrogen receptors alpha and beta. Journal of Biological Chemistry 277: 8702-8707.
Michael Plewa
Plewa, M. J., Wagner, E. D., Muellner, M. G., Hsu, K. M.; Richardson, S. D., Comparative Mammalian Cell Toxicity of N-DBPs and C-DBPs. ACS Book Chapter. In Press.

Plewa, M. J.; Muellner, M. G.; Richardson, S. D.; Fasano, F.; Buettner, K. M.; Woo, Y. T.; McKague, A. B.; Wagner, E. D., Occurrence, synthesis and mammalian cell cytotoxicity and genotoxicity of haloacetamides: An emerging class of nitrogenous drinking water disinfection by-products. Environ. Sci. Technol. 2008, 42, (3), 955-961.

Plewa, M. J.; Wagner, E. D.; Muellner, M. G.; Hsu, K. M.; Richardson, S. D., Comparative mammalian cell toxicity of N-DBPs and C-DBPs. In Occurrence, formation, health effects and control of disinfection by-products in drinking water, Karanfil, T.; Krasner, S. W.; Westerhoff, P.; Xie, Y., Eds. American Chemical Society: Washington, D.C., 2008; Vol. 995, pp 36-50.

Muellner, M.G., E.D. Wagner, K. McCalla, S. Richardson, Y-T. Woo and M. J. Plewa (2007) Haloacetonitriles versus regulated haloacetic acids: Are nitrogen containing DBPs more toxic? Environmental Science and Technology 41:645-651.

Rundell, M.S., Wagner E.D., and Plewa, M.J. (2003) The comet assay: Genotoxic damage or nuclear fragmentation? Environmental and Molecular Mutagenesis 42: 61-67.
Susan Schantz
Sable, H. J. K., Eubig, P. A., Powers, B. E., Wang, V. C., and Schantz, S. L. Developmental exposure to PCBs and/or MeHg: effects on a differential reinforcement of low rates (DRL) operant task before and after amphetamine drug challenge. Neurotoxicol Teratol in press.

Wang, V. C., Sable, H. J. K., Ju, Y. H., Allred, C. D., Helferich, W. G., Korol, D. L., and Schantz, S. L. (2008). Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding. Behav Neurosci, 122: 794-804.

Sable, H,J.K., Powers, B.E., Wang, V.C., Widholm, J.J., and Schantz, S.L. (2006) Alterations in DRH and DRL performance in rats developmentally exposed to an environmental PCB mixture. Neurotoxicology and Teratology: 28(5):548-56.

Roegge, C.S., Morris, J.R., Villareal, S., Wang, V.C., Powers, B.E., Klintsova, A.Y., Greenough, W.T. and Schantz, S.L. (2006) Purkinje cell and cerebellar effects following developmental exposure to PCB and/or MeHg. Neurotoxicology and Teratology:28:74-85.

Roegge, C.S., Wang, V.C., Powers, B.E., Klintsova, A.Y., Villareal, S., Greenough, W.T., and Schantz, S.L. (2004) Motor impairment in rats exposed to PCBs and methylmercury during early development. Toxicological Sciences 77:315-324.
Shelley Tischkau*
Bottum K.M., Poon, E, B Haley and Tischkau, S.A. (2006) The suprachiasmatic nucleus as a model for endogenous neuroprotection from glutamate excitoxicity. J Neurosci. (submitted).
Humphrey Yao
Tomaszewski J, Joseph A., Archambeault, D., Yao, H.H.C. (2007). Essential Roles of Inhibin beta A on Mouse Epididymal Coiling. Proceedings of National Academy of Sciences 104:11322-11327.

Archambeault D, Tomaszewski J, Joseph A, Yao HHC, Epithelium-mesenchyme crosstalk in Wolffian duct and fetal testis cord development. Genesis, (2008), manuscript accepted for publication.

Ditewig, A.C., Yao, H. Organogenesis of the ovary. A comparative review on vertebrate ovary formation. Organogenesis 2(2):36-41, 2005.


*former Training Program preceptor